A5078495480- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- IL-33, ST2, and ILC Pathways
- CAR-T cell therapy research
University of Basel
2023
Institute of Medical Microbiology and Hygiene
2019-2020
University of Freiburg
2019-2020
T cell factor 1 (Tcf-1) expressing CD8+ cells exhibit stem-like self-renewing capacity, rendering them key for immune defense against chronic viral infection and cancer. Yet, the signals that promote formation maintenance of these (CD8+SL) remain poorly defined.Studying differentiation in mice with infection, we identified alarmin interleukin-33 (IL-33) as pivotal expansion functioning CD8+SL well virus control. IL-33 receptor (ST2)-deficient exhibited biased end premature loss Tcf-1....
Natural intraepithelial lymphocytes (IELs) are thymus-derived adaptive immune cells, which important contributors to intestinal homeostasis. Similar other innate-like T they induced in the thymus through high-avidity interaction that would otherwise lead clonal deletion conventional CD4 and CD8 cells. By applying single-cell RNA-sequencing (scRNA-seq) on a heterogeneous population of thymic CD4-CD8αβ-TCRαβ+NK1.1- IEL precursors (NK1.1- IELPs), we define developmental trajectory can be...
The two T-box transcription factors T-bet and Eomesodermin (Eomes) are important regulators of cytotoxic lymphocytes (CTLs), such as activated CD8 T cells, which essential in the fight against intracellular pathogens tumors. Both share a great degree homology based on sequence analysis result exert partial functional redundancy during viral infection. However, actual between Eomes remains matter debate is further confounded by their distinct spatiotemporal expression pattern cells. To...