A5087815018- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Biochemical Analysis and Sensing Techniques
- Immunotherapy and Immune Responses
- Lysosomal Storage Disorders Research
- Cerebrovascular and genetic disorders
- T-cell and Retrovirus Studies
- Trypanosoma species research and implications
- Immune Response and Inflammation
- Virus-based gene therapy research
- Glycogen Storage Diseases and Myoclonus
- Alkaline Phosphatase Research Studies
- Medical and Biological Ozone Research
- Hearing, Cochlea, Tinnitus, Genetics
- Laser Applications in Dentistry and Medicine
- Ion Channels and Receptors
- Bone and Dental Protein Studies
- RNA regulation and disease
- Neurobiology and Insect Physiology Research
- Cell Image Analysis Techniques
- Salivary Gland Disorders and Functions
- Regulation of Appetite and Obesity
- Health, Environment, Cognitive Aging
- RNA Interference and Gene Delivery
- Single-cell and spatial transcriptomics
Versiti Blood Center of Wisconsin
2023-2024
Medical College of Wisconsin
2018-2024
ABSTRACT Fabry disease is an X‐linked lysosomal storage caused by α‐galactosidase A (α‐Gal A) deficiency. Kidney and heart failure are frequent complications in adulthood greatly contribute to patient morbidity mortality. Because α‐Gal A‐deficient mouse models do not recapitulate cardiorenal findings observed patients, a nonmouse model may be beneficial our understanding of pathogenesis. In this study, we evaluated processes recently generated rat model. We found that male rats weighed...
Autoimmune diseases, such as multiple sclerosis (MS), are often chronic with no cures. An underlying commonality of autoimmune diseases is immune-mediated inflammation. Control inflammation achieved by steroids and disease-modifying therapies, which can result in severe side-effects. CD4+Foxp3+ T regulatory cells (Treg), essential to controlling responses considered a strong therapeutic target minimal side effects. To that end, we leveraged our identification B cell IgD low (BDL) control...
The present study examined auditory function across age in the dark agouti (DA) rat strain. Auditory brainstem responses (ABRs) were measured for frequencies 8, 16, and 32 kHz male female DA rats from 3 to 18 months of age. Hearing thresholds absolute interpeak latencies (IPLs) analyzed. Male hearing remained stable first year life then significantly increased at all frequencies; tested ages out months. At 12 months, showed longer by (i.e., compared with 3-month-old males) sex (compared...
Abstract Multiple sclerosis is an autoimmune disease driven by T cell orchestrated demyelination. CD4+Foxp3+ regulatory cells (Treg) suppress autoimmunity; thus, therapies to increase endogenous Treg numbers are ideal. We identified a novel subset of IgM+IgDlow/- B (BDL) that induce proliferation in glucocorticoid-induced TNFR-related ligand (GITRL)-dependent manner via cell-cell contact. However, where BDL localize with the spleen unknown and imaging challenging due numerous required...
Abstract CD4+Foxp3+ T regulatory cells (Treg) are well characterized for their role in controlling autoimmunity. We have previously shown that mice deficient B (μMT) significantly reduced Treg and cannot recover from the mouse model of multiple sclerosis, experimental autoimmune encephalomyelitis (EAE), demonstrating a immune tolerance. Using cell depletion strategies phenotyping, we discovered IgD Low (BDL) when adoptively transferred into μMT increased numbers drove EAE recovery. BDL...
Abstract Multiple sclerosis (MS) is caused by a T cell orchestrated immune response to myelin sheath antigens of the central nervous system. Autoimmune responses can be suppressed CD4 +Foxp3 +T regulatory cells (Treg); therefore, therapeutic strategy increase endogenous Treg numbers. Our studies using mouse model MS, experimental autoimmune encephalomyelitis, have identified unique subset IgM +IgD low/−B (BD L) that induce proliferation in glucocorticoid-Induced TNFR-related...