A5065127116- Nerve injury and regeneration
- Neurogenesis and neuroplasticity mechanisms
- Neuroscience and Neuropharmacology Research
- Zebrafish Biomedical Research Applications
University of Helsinki
2019-2021
Abstract Neurotrophins and their receptors have highly conserved evolutionary lineage in vertebrates including zebrafish. The NTRK2 receptor has two isoforms zebrafish, Ntrk2a Ntrk2b. spatio-temporal expression pattern of bdnf ntrk2b the zebrafish brain was studied using situ hybridization. robust corresponding to suggests that is key for brain, unlike its duplicate isoform ntrk2a . To study function, different genetic strategies, TILLING mutant morpholino oligonucleotides (MO), were used....
Neurotrophin brain-derived neurotrophic factor (BDNF) and neurotransmitter serotonin (5-HT) regulate each other have been implicated in several neuronal mechanisms, including neuroplasticity. We investigated the effects of BDNF on serotonergic neurons by deleting receptor TrkB from adult brain. The transgenic mice show increased 5-HT Tph2 levels with abnormal behavioral phenotype. In spite food intake, are significantly leaner than their wildtype littermates, which may be due to metabolic...