A5075586469- Diabetes and associated disorders
- Diabetes Management and Research
- Pancreatic function and diabetes
- Thyroid Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Sexual Differentiation and Disorders
- Hemoglobinopathies and Related Disorders
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Vitamin D Research Studies
- Effects and risks of endocrine disrupting chemicals
- Thyroid Cancer Diagnosis and Treatment
- Neonatal Health and Biochemistry
- Blood groups and transfusion
- Child Nutrition and Water Access
- Diet and metabolism studies
- Iron Metabolism and Disorders
- Metabolism, Diabetes, and Cancer
- Parathyroid Disorders and Treatments
- Birth, Development, and Health
- Regulation of Appetite and Obesity
- Facial Nerve Paralysis Treatment and Research
- Cancer-related molecular mechanisms research
- Health and Lifestyle Studies
- Neuroscience of respiration and sleep
- Obesity, Physical Activity, Diet
Akdeniz University
2006-2022
Owl Research Institute
2019-2020
Dicle University
2014
Hitit Üniversitesi Çorum Eğitim ve Araştırma Hastanesi
2014
Child, Adolescent and Family Mental Health
2014
Akdeniz University Hospital
1992-2012
Combined pituitary hormone deficiency (CPHD) has an incidence of approximately 1 in 8000 births. Although the proportion familial CPHD cases is unknown, about 10% have affected first degree relative. We recently reported three mutations PROP1 gene that cause human subjects. report here frequency one these mutations, a 301–302delAG deletion exon 2 PROP1, 10 independently ascertained kindreds and 21 sporadic from 8 different countries. Our results show 55% (11 20) alleles cases. Interestingly,...
Bisphenol A (BPA) is an industrial chemical, particularly used to harden plastics. BPA thought have negative health effects on both laboratory animals and humans. Consider ing the decline in age of onset puberty noted recent years, among girls, importance as estrogenic endocrine disruptor has increased. In this study, we aimed determine urinary levels girls with idiopathic central precocious (ICPP).Non-obese newly diagnosed ICPP (n=28, 4-8 years) constituted study group. The control group...
Vitamin D-dependent rickets type 1A (VDDR-IA, OMIM 264700) is a rare autosomal recessive disorder and caused by mutations in the CYP27B1 gene.We aim to investigate mutation seven patients from four separate families characterize genotype-phenotype correlation.The entire coding region of gene was sequenced, correlation among assessed.Sequencing analysis identified biallelic all monoallelic their parents. One patient first family compound heterozygous for c.1166G>A (p.Arg389His) novel nonsense...
Abstract: Diabetic autonomic neuropathy (DAN) commonly complicates diabetes and is associated with increased mortality rates over 5 yr. This fact denotes the significance of DAN prevention, mainly effective glycemic control. However, total prevention in diabetic patients not achievable. Thus, timely detection use means to improve nervous system function or slow down its progression become utmost significance. Heart rate variability (HRV) a technique that measures beat-to-beat RR intervals,...
Article Bone Mineral Density and Alterations of Metabolism in Children Adolescents with Type 1 Diabetes Mellitus was published on June 1, 2006 the journal Journal Pediatric Endocrinology (volume 19, issue 6).
Childhood obesity (OB) is an acknowledged global problem with increasing prevalence reported around the world. We conducted this study aim of determining local trend in OB and overweight (OW) last decade to observe alteration OW by age group. An additional was construct new age- gender-specific body mass index (BMI) reference percentile charts for Turkish children living city center Antalya.This cross-sectional included 1687 school aged children. International Obesity Task Force guidelines...
There is a growing concern over the timing of pubertal breast development and its possible association with exposure to endocrine disrupting chemicals (EDCs), such as bisphenol A (BPA). BPA abundantly used harden plastics. The aim this study was investigate relation between premature thelarche (PT) by comparing urinary levels PT girls those healthy subjects. Twenty-five newly diagnosed nonobese subjects (aged 4-8 years) who were admitted Pediatric Endocrinology Department at Akdeniz...
Hyperinsulinemic hypoglycemia (HH) is the commonest cause of persistent in neonatal and infancy periods. Mutations ABCC8 KCNJ11 genes, which encode subunits ATP-sensitive potassium channel pancreatic beta cell, are identified approximately 50% these patients. The first-line drug treatment HH diazoxide. Octreotide glucagon can be used patients who show no response to Nifedipine, a calcium-channel blocker, has been shown an effective small number with diazoxide-unresponsive HH. We report...
A screening program was conducted to ascertain the incidence of hemoglobinopathies in district Antalya, Turkey. The survey sample selected from household registration forms health centers by systematic random sampling. Heparinized blood samples were collected 1,616 subjects 884 families.The prevalence p thalassemia traits with increased Hb A2 10.2%. This is higher than that found previous studies performed Antalya. abnormal hemoglobins (Hbs) be 0.8%. Four had AS; five D-Los Angeles (B 121...
Approaches to diagnosis and treatment of growth hormone deficiency (GHD) in children vary among countries even centers the same country. This survey, aiming facilitate process preparing new consensus on GHD by Turkish Pediatric Endocrinology Diabetes Society, was designed evaluate current practices different Turkey.A questionnaire covering relevant items for sent out all pediatric endocrinology centers.Twenty-four returned questionnaire. The most frequently used GH stimulation test L-dopa,...
Patients with DAX-1 gene mutations on chromosome Xp21 usually present adrenal hypoplasia congenita and hypogonadotropic hypogonadism. Yet, neither correlation between the type of mutation age onset disease nor mechanism puberty is fully understood. Here, we report a novel non-sense p.Gln208X in amino terminal domain observed large family three boys presenting manifestations at different ages. Furthermore, two developed spontaneous that failed to progress similar ages, whereas other boy...
Goiter prevalence and urinary iodine excretion levels were assessed in 605 schoolchildren (301 males 304 females), aged 6-11 years, living the Antalya region, a well known endemic goiter area Turkey. was evaluated by clinical examination ultrasound of thyroid gland. Urinary expressed as microg/g creatinine. inspection palpation found 35% (n = 212) all subjects, 37.5% 114) girls 32.5% 98) boys. Iodine deficiency moderate degree detected from point prevalence. With regard to upper limits...
Wolcott-Rallison syndrome (WRS) is a rare autosomal recessive disorder characterized by early-onset diabetes, spondyloepiphyseal dysplasia, tendency to skeletal fractures secondary osteopenia, and growth retardation. Mutations in the eukaryotic translation initiation factor 2α kinase (EIF2AK3) gene are responsible for this disorder. Here, we describe boy with neonatal diagnosed at 2 months of age, who developed severe retardation fracture during follow-up period. The patient's X-ray revealed...
Abstract Background: The aim of the study was to assess response growth hormone (GH) treatment in very young patients with GH deficiency (GHD) through a national, multi-center study. Possible factors affecting were assessed (especially mini-puberty). Methods: Medical reports GHD whom initiated between 0 and 3 years age retrospectively evaluated. Results: cohort numbered 67. diagnosis 12.4±8.6 months, peak stimulation test (at diagnosis) as 1.0±1.4 ng/mL. first second length gain 15.0±4.3...