Zixiang Jian

ORCID: 0000-0003-0244-0694
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About
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Research Areas
  • Chemokine receptors and signaling
  • Osteoarthritis Treatment and Mechanisms
  • Temporomandibular Joint Disorders
  • Connexins and lens biology
  • Rheumatoid Arthritis Research and Therapies
  • Medicinal plant effects and applications
  • Advanced Glycation End Products research
  • Photoacoustic and Ultrasonic Imaging
  • Sirtuins and Resveratrol in Medicine
  • Ultrasound and Hyperthermia Applications
  • Pain Mechanisms and Treatments
  • Adipose Tissue and Metabolism
  • Protease and Inhibitor Mechanisms
  • Inflammasome and immune disorders

Chongqing Medical University
2020-2023

Stomatological Hospital of Chongqing Medical University
2022-2023

The Affiliated Yongchuan Hospital of Chongqing Medical University
2022

Advanced glycation end products (AGEs) accumulate in the bone tissue of patients with diabetes mellitus, resulting oxidative stress, poor healing, or regeneration. Irisin, a novel exercise-induced myokine, is involved regulation metabolism. However, effects irisin on adipose-derived stem cell (ASC) osteogenic differentiation and healing under diabetic conditions remain poorly understood. ASCs were obtained from inguinal fat Sprague-Dawley rats treated different concentrations AGEs irisin....

10.1155/2022/3319056 article EN cc-by Oxidative Medicine and Cellular Longevity 2022-10-10

C-reactive protein (CRP), a biomarker of inflammation, is highly expressed in osteoarthritis- (OA-) related diseases, but its exact role remains unknown. In this study, we evaluated the biological effect CRP on temporomandibular joint (TMJ) inflammation. Freund's complete adjuvant (CFA) was used to induce TMJ inflammation CRP-knockout (CRP-/-) and control rats. Degenerative changes were compared elucidate addition, inflammatory cytokines, macrophage activation, osteoclast differentiation by...

10.1155/2022/8613986 article EN cc-by Journal of Immunology Research 2022-01-10

Abstract Background: C-reactive protein (CRP), as the biomarker for inflammation, high expresses in osteoarthritis (OA) related diseases with exact role been clouded. In this study, we evaluated biological effect of CRP temporomandibular joint (TMJ-OA). Methods: Freund’s complete adjuvant (CFA) was used TMJ inflammation induction knock out (CRP -/-) and control rats. And degenerative changes, such synovitis performance, disc morphological changes cartilage degeneration were compared to...

10.21203/rs.3.rs-115377/v1 preprint EN cc-by Research Square (Research Square) 2020-12-01

Abstract Background: C-reactive protein (CRP), a biomarker of inflammation, is highly expressed in osteoarthritis (OA)-related diseases, but its exact role remains unknown. In this study, we evaluated the biological effect CRP on temporomandibular joint (TMJ) inflammation. Methods: Freund’s complete adjuvant (CFA) was used to induce TMJ inflammation CRP-knockout (CRP-/-) and control rats. Degenerative changes were compared elucidate addition, inflammatory cytokines, macrophage activation...

10.21203/rs.3.rs-115377/v3 preprint EN cc-by Research Square (Research Square) 2021-12-15

Abstract Background: C-reactive protein (CRP), a biomarker of inflammation, is highly expressed in osteoarthritis (OA)-related diseases, but its exact role remains unknown. In this study, we evaluated the biological effect CRP on temporomandibular joint (TMJ) inflammation. Methods: Freund’s complete adjuvant (CFA) was used to induce TMJ inflammation CRP-knockout (CRP-/-) and control rats. Degenerative changes were compared elucidate addition, inflammatory cytokines, macrophage activation...

10.21203/rs.3.rs-115377/v2 preprint EN cc-by Research Square (Research Square) 2021-09-27
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