A5101906296- Prostate Cancer Treatment and Research
- Radiopharmaceutical Chemistry and Applications
- Graphene research and applications
- Oral microbiology and periodontitis research
- Topological Materials and Phenomena
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Genetic factors in colorectal cancer
- Immune Response and Inflammation
- Cancer Immunotherapy and Biomarkers
- Cancer, Lipids, and Metabolism
- Extracellular vesicles in disease
- Colorectal Cancer Treatments and Studies
- Viral Infections and Vectors
- Cancer Genomics and Diagnostics
- Colorectal Cancer Surgical Treatments
- Prostate Cancer Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- dental development and anomalies
- Ocular and Laser Science Research
- Oral and gingival health research
- Adipose Tissue and Metabolism
- Advanced Condensed Matter Physics
- Colorectal and Anal Carcinomas
- 2D Materials and Applications
Chongqing Medical University
2016-2025
Children's Hospital of Chongqing Medical University
2025
National Clinical Research
2025
Stomatological Hospital of Chongqing Medical University
2018-2024
Jinzhou Medical University
2024
Fudan University Shanghai Cancer Center
2021-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
The Affiliated Yongchuan Hospital of Chongqing Medical University
2019-2023
Shanghai Medical College of Fudan University
2021-2023
Binzhou Medical University
2022-2023
Periodontitis is the most widespread oral disease and closely related to microbiota. The microbiota adversely affected by some pharmacologic treatments. Systemic antibiotics are widely used for infectious diseases but can lead gut dysbiosis, causing negative effects on human body. Whether systemic antibiotic-induced dysbiosis affect or even periodontitis has not yet been addressed. In this research, mice were exposed drinking water containing a cocktail of four explore how pathogenicity bone...
Signaling pathways are used reiteratively in different developmental processes yet produce distinct cell fates through specific downstream transcription factors. In this study, we tooth root development as a model with which to investigate how the BMP signaling pathway regulates transcriptional complexes direct fate determination of multipotent mesenchymal stem cells (MSCs). We first identified MSC population supporting mouse molar growth Gli1+ cells. Using Gli1-driven Cre-mediated...
Advanced glycation end products (AGEs) accumulate in the bone tissue of patients with diabetes mellitus, resulting oxidative stress, poor healing, or regeneration. Irisin, a novel exercise-induced myokine, is involved regulation metabolism. However, effects irisin on adipose-derived stem cell (ASC) osteogenic differentiation and healing under diabetic conditions remain poorly understood. ASCs were obtained from inguinal fat Sprague-Dawley rats treated different concentrations AGEs irisin....
A well-recognized risk factor for periodontitis, diabetes mellitus (DM) aggravates periodontal disease with increasing alveolar bone loss. As a novel myokine, irisin is closely linked metabolism. Nonetheless, the effects of on periodontitis under diabetic conditions and underlying mechanisms remain poorly understood. Here, we showed that local treatment ameliorates loss oxidative stress, increases SIRT3 expression within tissues our experimentally-induced (DP) rat models. By culturing...
Abstract Red blood cells (RBCs) transport oxygen to tissues and remove carbon dioxide. Diffuse optical flowmetry (DOF) assesses deep tissue RBC dynamics by measuring coherent fluctuations of multiply scattered near-infrared light intensity. While classical DOF measurements empirically correlate with flow, they remain far-removed from scattering physics difficult interpret in layered media. To advance closer the physics, here we introduce an interferometric technique, surmounting challenges...
The balance between pro- and anti-inflammatory signals maintains tissue homeostasis defines the outcome of chronic inflammatory diseases such as periodontitis, a condition that afflicts tooth-supporting tissues exerts an impact on systemic health. induction inflammation relies heavily Toll-like receptor (TLR) signaling, which drives proinflammatory pathway through recruiting myeloid differentiation primary response gene 88 (MyD88) activating nuclear factor kappa-light-chain-enhancer...
Osteosarcoma is the most common primary bone cancer in children and young adults. It highly aggressive patients that present with metastasis have a poor prognosis. Angiopoietin-like 4 (ANGPTL4) drives progression of many solid tumours, but has not been described osteosarcoma tissue. ANGPTL4 also enhances osteoclast activity, which required for growth bone. We therefore investigated expression function human tissue cell lines. Expression microarrays was determined by immunohistochemistry....
Extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) have emerged as a new mode of intercellular crosstalk and are responsible for many the therapeutic effects MSCs. To promote application MSC-EVs, recent studies focused on manipulation MSCs to improve production EVs EV-mediated activities. The current paper details an optimization method using non-invasive low-intensity pulsed ultrasound (LIPUS) stimulation improving oral MSC-EV effectiveness. Stem apical papilla (SCAP),...
Abstract Aim To explore the role of C‐reactive protein (CRP) in periodontitis and diabetes its mechanism alveolar bone homeostasis. Materials Methods In vivo, normal, Crp knockout (KO) rats were randomly divided into control, diabetes, periodontitis, groups, respectively. The model was established using a high‐fat diet combined with streptozotocin injection. by ligature lipopolysaccharide (LPS) Alveolar bones analysed micro‐computed tomography, histology, immunohistochemistry. vitro, human...
From the bipolar cells to higher brain visual centers, signals in vertebrate system are transmitted along parallel on and off pathways. These two pathways spatially segregated depth axis of retina. Yet, our knowledge, there is no way directly assess this anatomical stratification vivo. Here, employing ultrahigh resolution visible light Optical Coherence Tomography (OCT) imaging humans, we report a stereotyped reflectivity pattern inner plexiform layer (IPL) that parallels IPL stratification....
Objectives: To evaluate the longitudinal patterns of burden adverse effects medical treatment (AEMT) in children and adolescents China from 1990 to 2021. Methods: Data used this study were obtained public data sets Global Burden Disease AEMT was defined as harm resulting procedures, treatments, or other contacts with health care system. The case number, crude rates, age-standardised rates (ASR) incidence, deaths, disability-adjusted life-years (DALYs), grouped by age sex, primary outcomes...