Responding to the tumor microenvironment, functional polymers can serve as preeminent drug carriers for targeted cancer therapy. Stimuli-responsive polymeric are reported with diverse anti-tumor effects various polymer structures. Thus, three pH/redox dual-responsive amphiphilic zwitterionic 'isomers' different locations of responsive units were prepared understand relationship between structure and effect. Containing poly(ε-caprolactone) (PCL), poly(N,N-diethylaminoethyl methacrylate)...

Objectives To evaluate the efficacy and safety of biliary stenting implantation with iodine-125 seed strand (SI) followed by hepatic artery infusion chemotherapy (HAIC) plus lenvatinib (Len) programmed death-1 (PD-1) inhibitor for patients diagnosed extrahepatic cholangiocarcinoma (ECC) malignant obstructive jaundice (MOJ). Methods In this single-center retrospective study, data ECC MOJ from March 2015 to January 2023 was assessed. Using probability score matching (PSM), selection bias...

Abstract Background Increased tryptophan (Trp) metabolism by indoleamine 2,3-dioxygenase (IDO)/tryptophan (TDO) represents one of the most studied pathways for immunosuppression in tumor tissues. However, pro-tumor effects induced Trp remain controversial. Methods The paraffin sections tissues were obtained from patients with liver cancer and examined immunohistochemical staining to investigate role metabolic enzymes. To further confirm TDO2, we established TDO2 overexpression SMC-7721 HepG2...

Using copper sulfide nanoparticles as cross-linkers of tumor microenvironment responsive polymer micelles for cancer synergistic photo-chemotherapy presents promising therapeutic effects in treatment.

The effective accumulation at tumor sites and endocytosis by cells for anticancer agents in carriers are essential successful cancer therapy, both of the processes affected surface charge drug carriers. In this study, vitamin C (VC) was employed as an "exogenous switch" to trigger conversion DOX-loaded micelles obtain a better antitumor effect. T formed poly(ε-caprolactone)-b-poly(N,N-diethylaminoethyl methacrylate)-ss-b-poly(2-methacryloyloxyethyl phosphorylcholine) (PCL–PDEA-ss-PMPC)...

Premature leakage of drugs during blood circulation and slow drug release at the tumor site are two major challenges that nanocarriers have to overcome achieve successful cancer therapy.

Abstract Background The purpose of this study was to assess the safety and efficacy percutaneous transcatheter embolization (TCE) for treatment pulmonary arteriovenous malformations (PAVMs). Methods Forty-three consecutive patients (n = 17 males; n 26 females) with 72 untreated PAVMs underwent coil and/or plug between January 2010 February 2018. mean patient age 42 ± 14 years (range 19–71 years). median size feeding artery 7.9 2.9 mm 3.5–14.0 mm). arterial blood gas level cardiac function...

Zwitterionic polymers have unique features, such as good compatibility, and show promise in the application of drug delivery. In this study, zwitterionic copolymers, poly(ε-caprolactone)-b-poly(2-methacryloyloxyethyl phosphorylcholine) with disulfide (PCL-ss-PMPC) or without (PCL-PMPC) different block lengths PCL-ss-PMPC, were designed. The designed copolymers obtained by a combination ring-opening polymerization atom transferring radical polymerization. crystallization properties these...

The polymeric architecture greatly influences the properties of polymer drug carriers.

Wireless sensor networks (WSN) greatly extend our ability to monitor and control the physical world. It can collaborate aggregate a huge amount of sensed data provide continuous spatially dense observation environment. The monitoring indoor atmosphere conditions represents an important task with aim ensuring suitable working living spaces people. However, comprehensive air quality, which includes humidity, temperature, gas concentrations, etc., is not so easy be monitored controlled. In this...

The majority of patients with hepatocellular carcinoma (HCC) are diagnosed in an advanced stage. Although sorafenib is recommended as the standard treatment for HCC, its efficacy limited. In some studies, hepatic arterial infusion chemotherapy has demonstrated a significant therapeutic benefit HCC compared sorafenib. We systematically evaluated and safety HCC.A systematic search PubMed, Embase, Web Science Cochrane Library up to December 31, 2020 was conducted. Study outcomes included...

In order to apply Radio Frequency Micro-nano-Electro-Mechanical System (MEMS/NEMS) technologies produce miniature, high isolation, low insertion loss, good linear characteristic, and power consumption microwave switches, we present a novel NEMS switch with nanoscaling in this paper through the analysis of electrics mechanics RF switch. The measured data show pull-in voltage 24.1 V performance loss below −10 dB at 0 GHz on “on” state, isolation beyond –40 0–40 “off” indicating that witch is...

This article describes the design and simulation of a novel multi-functional hinge equipped with rotary magnetorheological damper for solar array deployment system, which is comprised hinge, an angular sensor, positioning locking mechanism damper. In order to achieve compact in structure, some components were reused different function modules. It's first use magnet-rheological fluid (MRF) dissipate energy system. The main advantage using MR instead viscous that damping force can be adjusted...

Surface physicochemistry properties of polymer particles are crucial for protein corona formation and macrophage phagocytosis when they contact with living body. In this work, polystyrene microspheres (PS-MSs) were selected as a model microparticles fabricated by chromic acid etching through controlling conditions to obtain different surface morphology structures investigate their effect on the adsorption phagocytic uptake PS-MSs. The bovine serum albumin (BSA) fibrinogen (FIB) PS-MSs showed...

Abstract Multidrug delivery systems are capturing much attention while ingenious drug carriers researchers' pursuit. A method building dual‐polymer nanoparticles (DPNs), one analogous micelle nanoparticle, with double hydrophobic core layers and a hydrophilic shell, is developed by combining co‐axial injection solvent evaporation using an amphiphilic polymer. Hydrophobic drugs can be efficiently zonally encapsulated in and/or outer zone of DPN. As result, DPN sequentially release appears...

This paper presents a high-precision and low-power two-stage miller-compensated instrumentation amplifier for sensor readout circuits. Folded-cascode structure with complementary input differential pairs translinear-loop-based class AB circuit are adopted as the first second stages respectively, to achieve rail-to-rail output ranges. The presented is implemented in 0.18μm BCD technology. Measurement results show that load of 100pF 100kΩ, achieves 79. 79dB gain, 1. 35MHz gain-bandwidth...

With the rapid development of RF-MEMS (NEMS) switch, high isolation, low insertion loss, good linear characteristic and power consumption microwave switches are impending. Through analysis electrics mechanics RF a novel NEMS switch with nano-scaling is presented in this paper. The measured data show pull-in voltage 24.1V performance loss beyond -20dB @0-40GHz on "on" state, isolation below -25dB at 0-40GHz "off" indicating that witch suitable for 0-20GHz applications. Haar-Wavelet-Based...