A5025388625- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Neuroscience and Neuropharmacology Research
- Treatment of Major Depression
- Pain Mechanisms and Treatments
- Neurological disorders and treatments
- Transcranial Magnetic Stimulation Studies
- Neuroendocrine regulation and behavior
- Neurogenesis and neuroplasticity mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Pharmacological Receptor Mechanisms and Effects
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurotransmitter Receptor Influence on Behavior
- Mangiferin and Mango Extracts
- Cannabis and Cannabinoid Research
- Social Media in Health Education
- Maternal Mental Health During Pregnancy and Postpartum
- Vitamin D Research Studies
- Myofascial pain diagnosis and treatment
- Optical Imaging and Spectroscopy Techniques
- Genetic Neurodegenerative Diseases
- Neural dynamics and brain function
- Photoreceptor and optogenetics research
- Acupuncture Treatment Research Studies
- Enzyme Catalysis and Immobilization
Universidad de Cádiz
2013-2024
Centro de Investigación Biomédica en Red de Salud Mental
2012-2024
Biomedical Research and Innovation Institute of Cadiz
2017-2023
Hospital Universitario Puerta del Mar
2011-2023
Instituto de Salud Carlos III
2011-2022
Centro Nacional de Microbiologia
2011-2018
National Pedagogic University
2016
Stressful experiences seem to negatively influence pain perception through as yet unknown mechanisms. As the noradrenergic locus coeruleus (LC) nucleus coordinates many components of stress response, well nociceptive transmission, we evaluated whether sensory and affective dimension chronic neuropathic worsens in situations due adaptive changes LC neurons. Accordingly, male rats were socially isolated for 5 weeks, last 2 was induced by constriction injury. In this situation stress,...
Abstract Schizophrenia is a chronic neurodevelopmental disorder with an inflammatory/prooxidant component. N-acetylcysteine (NAC) has been evaluated in schizophrenia as adjuvant to antipsychotics, but its role preventive strategy not sufficiently explored. We aimed evaluate the potential of NAC administration two-time windows before onset symptoms schizophrenia-like maternal immune stimulation (MIS) rat model. Pregnant Wistar rats were injected Poly I:C or Saline on gestational day (GD) 15....
Abstract The brainstem region, locus coeruleus (LC), has been remarkably conserved across vertebrates. Evolution woven the LC into wide-ranging neural circuits that influence functions as broad autonomic systems, stress response, nociception, sleep, and high-level cognition among others. Given this conservation, there is a strong possibility activity inherently similar species, furthermore age, sex, brain state similarly species. degree to which homogenous these factors, however, never...
Minocycline (MIN) is a tetracycline with antioxidant, anti-inflammatory, and neuroprotective properties. Given the likely involvement of inflammation oxidative stress (IOS) in schizophrenia, MIN has been proposed as potential adjuvant treatment this pathology. We tested an early therapeutic window, during adolescence, prevention schizophrenia-related deficits maternal immune stimulation (MIS) animal model.On gestational day 15, Poly I:C or vehicle was injected pregnant Wistar rats. A total...
There is evidence that in schizophrenia, imbalances inflammatory and oxidative processes occur during pregnancy the early postnatal period, generating interest potential therapeutic efficacy of anti-inflammatory antioxidant compounds. Mangiferin a polyphenolic compound abundant leaves
Most current disease-modifying therapies approved for multiple sclerosis (MS) are immunomodulatory drugs that counteract the aberrant activity of immune system. Hence, new pharmacological interventions drive anti-inflammatory and neuroprotection would represent interesting alternative therapeutic approaches or complementary strategies to treat progressive forms MS. There is evidence reduced noradrenaline levels alterations locus coeruleus (LC) noradrenergic neurons in MS patients, as well...
Strong evidence from studies on primates and rodents shows that changes in pupil diameter may reflect neural activity the locus coeruleus (LC). Pupillometry is only available non-invasive technique could be used as a reliable easily accessible real-time biomarker of vivo LC. However, application pupillometry to preclinical research not yet fully standardized. A lack consensus technical specifications some components for image recording or positioning animal cameras have been recorded recent...
Method A website was designed to offer psychoeducation and advice women who demand more information about health after traditional visit GPs. total of 564 patients visited the in three months. Women asked for interacted with different topics on platform. Only completed all form (age, previous diseases, current treatment) were analyzed. 226 e-patients included. Results The most demanded about: excess weight, fibromyalgia, depression, anxiety, bipolar disorder menopause although other related...