A5067170525- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Stress Responses and Cortisol
- Alzheimer's disease research and treatments
- Neurological Disorders and Treatments
- Schizophrenia research and treatment
- Gut microbiota and health
- Antioxidant Activity and Oxidative Stress
- Cancer-related cognitive impairment studies
- Dermatology and Skin Diseases
- Nerve injury and regeneration
- Diabetes and associated disorders
- S100 Proteins and Annexins
- Coenzyme Q10 studies and effects
- Influenza Virus Research Studies
- Anesthesia and Neurotoxicity Research
- Neurological Disease Mechanisms and Treatments
- DNA Repair Mechanisms
- Mental Health and Psychiatry
- Alcohol Consumption and Health Effects
- Alcoholism and Thiamine Deficiency
- Immune Cell Function and Interaction
- T-cell and Retrovirus Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Autoimmune and Inflammatory Disorders Research
Federal Medical-Biological Agency
2021-2025
Kurchatov Institute
2018-2025
Federal Research and Clinical Center of Physical-Chemical Medicine named after Y.M. Lopukhin
2014-2024
State Research Institute of Highly Pure Biopreparations
2018-2022
Center for Theoretical Problems of Physicochemical Pharmacology
2017
The aim of the study was to identify genetic markers schizophrenia based on exome sequencing data, as well specify its potential relation clinical manifestations disease, morphological changes in brain and immune disorders. analyzed sample consisted 48 patients (23 men 25 women; average age - 31.5±7.7 years) having a confirmed diagnosis paranoid schizophrenia. 140 genes with differential polymorphisms enriched categories that may be related pathogenesis were identified. Analysis frequencies...
The review addresses immunological aspects of schizophrenia, a multifactor disease caused by genetic factors, innate disorders the central nervous system (CNS), including consequences perinatal hypoxia and infections, adverse environmental influences. Neuroinflammation as part pathophysiology schizophrenia is characterized higher transcription CNS inflammatory mediators, excessive activation microglia, inhibition glutamatergic receptors that leads to decrease in number cortical synapses...
was to analyze the immune-inflammatory profile of patients with paranoid schizophrenia and relate it severity negative symptoms MRI data in order identify biomarkers severity, search for new approaches therapy, control its effectiveness.
To study clinical effects of cerebrolysin and its impact on systemic inflammation markers immunity in mild cognitive impairment (MCI).Twenty patients with MCI were treated administered intravenously during 4 weeks. Serum levels immunoglobulins, inflammatory markers, neurotrophic factors measured dynamics controls using ELISA.An effect was found including the older group (mean age 78±1.1 years). An improvement seen 6 and/or 22 weeks after treatment. Four types response to treatment (fast...
to evaluate the levels of cytokines (IFNα, IFNγ, IL-2, Il-4, IL-6, IL-8, IL-10, IL-12, IL-15), IL-1β receptor antagonist (IL-1RA), vascular endothelial growth factor (VEGF) and its antagonist, soluble form 1 (sVEGFR1) in blood serum patients with Alzheimer's disease, early onset (ADEO) late (ADLO), mild cognitive impairment (MCI).Levels interleukins, IL-1RA, VEGF sVEGFR1 were measured 20 AD 11 MCI using ELISA. These parameters compared severity assessed by performance on neurocognitive...
The aims of the project were to study architecture brain's neural networks in process perceiving individual stimuli that are personally significant, evaluate main parameters immunity and systemic inflammation, relate those brain damage markers patterns cognitive-affective disorders patients with schizophrenia.Materials Methods.The involved 35 paranoid schizophrenia 17 people without cognitive impairment.Clinical information about was obtained from database created Alekseev Psychiatric...
Objective To search for the relationship between results of functional imaging, immunological parameters and laboratory markers inflammation in schizophrenia, taking into account cognitive impairment patients, to consider possibility using a multidisciplinary approach diagnosis, treatment prognosis schizophrenia. Material methods The study included 25 patients with schizophrenia 13 healthy volunteers. Psychiatric scales were administered evaluate patient's condition. main indicators humoral...
Schizophrenia is a chronic disease characterized by psychosis, behavioral, cognitive and social impairments. It accompanied structural functional changes in the brain. To confirm significance of morphometric changes, it important to establish relationships between brain, clinical symptoms, level biomarkers reflecting pathogenesis disease, including immunological markers. The aim this work was assess relationship interleukin-6 (IL-6) levels with systemic inflammation, immune activation...
Alzheimer's disease is the most common neurodegenerative in old age. In some cases, it preceded by mild cognitive impairment (MCI). One of important components pathogenesis neurodegeneration chronic neuroinflammation (inflammatory activation microglia and astrocytes brain). Systemic inflammatory response immune dysregulation may contribute to neuroinflammation. The purpose this study was investigate level chemokines other mediators patients with MCI who underwent medical rehabilitation, its...
Amnestic mild cognitive impairment (aMCI) is considered as a possible earliest pre-dementia clinical stage of Alzheimer's disease (AD). Taking into account the prominent role neuroinflammation in pathogenesis AD, it quite important to study immunological markers risk aMCI progression and changes immune parameters patients.To variants AD based on humoral cell immunity, levels key cytokines presence systemic inflammation, explore link between prognosis.One hundred patients with diagnosis aMCI,...
Introduction. Associations of disturbances in innate and adaptive immunity during the clinical course schizophrenia have been found a number studies. Yet, relationship immune parameters systemic inflammation relation to disease its prognosis, remains poorly understood, which highlights an interesting topic for further research. The goal this study was research immuno-inflammatory changes patients with continuous episodic paranoid schizophrenia, assess pathogenetic significance these...
The goal of this research was to study the clinical efficacy course-based neurotrophic therapy in mild cognitive impairment (MCI) and effect on immune parameters patients, assess prognostic value dynamics during year after treatment. 20 patients with MCI receiving intravenous Cerebrolysin (20 infusions 30 ml increasing dose first four days) were examined. Neuropsychological immunological examination carried out immediately before study, 3 months., 6 months 1 end It found that therapy, had a...
The goal of this work was to investigate the associations between IL-17A levels and structural MRI findings clarify immune factors pathogenesis search for biomarkers unfavorable disease course. 45 patients with schizophrenia 30 healthy volunteers were enrolled into study. cytokines (IL-1β, IL-4, IL-6, IL-8, IL-17A) inflammatory markers determined by ELISA. scans performed on a Siemens Magnetom Verio 3T scanner. It found that elevated cytokine are associated morphometric changes in frontal...
In this study, for the first time, data were obtained on architecture of effective connections in extended default neural network patients with schizophrenia and healthy controls. Also, a determination immunological status was performed. At rest, connectomes subjects had significant differences strength connections. Immunological analysis showed that despite clinical improvement after inpatient treatment, most elevated levels markers systemic inflammation activation humoral immunity. next...
To study the relationship of parameters immunity and systemic inflammation with structural magnetic resonance imaging (MRI) in patients mild cognitive impairment (MCI) pre-MCI undergoing neurocognitive rehabilitation to search for candidate markers its effectiveness.
IL-17A is a proinflammatory cytokine involved in pathogenesis of some neuroinflammatory diseases the brain. However, its role schizophrenia poorly understood. Currently, noninvasive neuroimaging techniques are widely used to assess abnormalities brain morphology and interactions neuronal networks schizophrenia. The aim this work was study associations between level morphometric parameters schizophrenia, order clarify immune factors search for biomarkers unfavorable disease course. 45...
Alzheimer's disease (AD) is a multifactorial that leads to progressive memory loss, visualspatial impairments, emotional and personality changes. As its earliest pre-dementia clinical stage, amnestic mild cognitive impairment syndrome (aMCI) currently considered. Neuroinflammation plays role in the development progression of aMCI initial stage AD, which can be supported by immunological disorders systemic character. Study factors, including infections, influencing immune inflammatory...
The aim of the work was to study factors natural and adaptive immunity systemic inflammation in subacute stage schizophrenia clarify role these systems chronization disease. 31 patients with diagnosis (SCI) paranoid after 3-4 weeks therapy were examined. control group included 16 healthy volunteers. Markers immunity, including key cytokines lymphocyte subpopulations, investigated. Increased levels IgМ, C-reactive protein cortisol blood found SCI. Also most cases content proinflammatory...