A5035318207- Congenital heart defects research
- Parasite Biology and Host Interactions
- Zebrafish Biomedical Research Applications
- Identification and Quantification in Food
- Effects and risks of endocrine disrupting chemicals
- Autophagy in Disease and Therapy
- Marine Ecology and Invasive Species
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Micro and Nano Robotics
- Microplastics and Plastic Pollution
- Mollusks and Parasites Studies
- Animal testing and alternatives
- Dental Erosion and Treatment
- Molecular Biology Techniques and Applications
- Parasitic Infections and Diagnostics
- Cardiac Ischemia and Reperfusion
- Synthesis of Indole Derivatives
- Curcumin's Biomedical Applications
- Cardiac Fibrosis and Remodeling
- Vector-borne infectious diseases
- Metabolomics and Mass Spectrometry Studies
- Animal Genetics and Reproduction
- Bioactive natural compounds
- Coccidia and coccidiosis research
- Robotics and Sensor-Based Localization
Guangxi Normal University
2021-2024
Hong Kong Science and Technology Parks Corporation
2020-2021
City University of Hong Kong
2014-2021
Vitargent (China)
2020
Xiamen University
2009-2010
Chongqing Medical University
2006
Chinese Academy of Sciences
2004
Xinjiang Institute of Ecology and Geography
2004
Phthalates, widely used in flexible plastics and consumer products, have become ubiquitous contaminants worldwide. This study evaluated the acute toxicity estrogenic endocrine disrupting activity of butyl benzyl phthalate (BBP), di(n-butyl) (DBP), bis(2-ethylhexyl) (DEHP), diisodecyl (DIDP), diisononyl (DINP), di-n-octyl (DNOP) their mixtures. Using a 72 h zebrafish embryo test, LC50 values BBP, DBP mixture six phthalates were found to be 0.72, 0.63 0.50 ppm, respectively. The other four did...
Abstract In zebrafish, the role of matrix metalloproteinases (MMPs) in inflammatory phase heart regeneration following cryoinjury remains poorly understood. Here, we demonstrated an increase MMP enzymatic activity and elevated expression mmp9 mmp13 injured area (IA) hearts from as early 1 day post-cryoinjury (dpc). Treatment with broad-spectrum inhibitor, GM6001, during first week after resulted impaired regeneration, indicated by larger scar reduced numbers proliferating cardiomyocytes....
Phthalates are commonly used in plastic products daily life. The endocrine-disrupting effects of phthalates have been widely reported. Accumulating evidence from human cohorts and lab animals indicate exposure to might impair neurodevelopment. However, the direct causal relationship mechanism between with neurodevelopment neurotoxicity not firmly established. We found that (i.e. DBP, DINP, BBP) disrupted expression estrogen receptors (esr1, esr2a, esr2b), impaired neurogenesis brain...
Curcumin is a natural active product extracted from turmeric, has been reported to have anticancer properties against various tumors. However, the effect of curcumin on colon cancer remains still unclear. Our aimed investigate anti-colon in vitro, and determine molecular mechanisms underlying these effects. Viability assays including CCK8 LDH were used measure cell proliferation. Flow cytometry was performed detect apoptosis cycle distribution. qRT-PCR Western blotting for measuring...
Rehmanniae Radix Praeparata (RRP), a staple in traditional Chinese medicine, is derived from Rehmannia glutinosa Libosch and renowned for its wound-healing properties. Despite clinical prevalence, the molecular mechanisms underlying RRP's effects have not been fully elucidated.
Sexual differences have been observed in the onset and prognosis of human cardiovascular diseases, but underlying mechanisms are not clear. Here, we found that zebrafish heart regeneration is faster females, can be accelerated by estrogen suppressed estrogen-antagonist tamoxifen. Injuries to heart, other tissues, increased plasma levels expression receptors, especially esr2a. The resulting endocrine disruption induces female-specific protein vitellogenin male zebrafish. Transcriptomic...
Metformin is one of the most widely used drugs for type 2 diabetes and it also exhibits cardiovascular protective activity. However, underlying mechanism its action not well understood. Here, we an adult zebrafish model heart cryoinjury, which mimics myocardial infarction in humans, demonstrated that autophagy was significantly induced injured area. Through a systematic evaluation multiple cell types related to cardiac regeneration, found metformin enhanced autophagic flux improved...
Inflammation plays a crucial role in cardiac regeneration. Numerous advantages, including robust regenerative ability, make the zebrafish popular model to study cardiovascular diseases. The breakdance (bre) mutant shares several key features with human long QT syndrome that predisposes ventricular arrhythmias and sudden death. However, how inflammatory response tissue regeneration following damage occur bre is unknown. Here, we have found related genes were markedly expressed injured heart...
In vivo manipulation of microparticles, such as biological cells and drugs, has attracted considerable attention in recent years. This paper presents the development robot-aided technology that can control targeted microparticles to move a relatively long distance an environment. The field view be updated online, controlled microparticle tracked automatically transportation. Simultaneous localization mapping for applications are first investigated. Based on map, artificial potential...
Cancer stem cells are involved in cancer establishment, progression, and resistance to current treatments. We demonstrated the vitro vivo anti-breast effect of bakuchiol a previous study. However, ability target breast (BCSCs) inhibit metastasis remains unknown. In study, we used cell surface markers CD44 CD24 distinguish BCSCs from MCF-7 cells. Bakuchiol inhibited mammosphere formation aldehyde dehydrogenase (ALDH) activity BCSCs. Moreover, induced apoptosis suppressed mitochondrial...
Cannabidiol (CBD) extracts have gained attention for their therapeutic efficacy. The present study used a zebrafish embryo caudal fin amputation model and found 1.25 mg/L crude CBD extract accelerated regeneration reduced apoptosis after amputation, while not altering mitotic regenerating cells. purity of the was 55.5 ± 0.37%. Pure promoted inhibited neutrophil accumulation in dose-dependent manner, these effects were seen high concentration (2.5 mg/L), possibly due to toxicity dose. An...
AbstractAbstractThe Organization for Economic Co-operation and Development (OECD）Test Guideline (TG) 236 zebrafish embryo acute toxicity testing was adopted chemical assessment in 2013. Due to the increasing demand prediction evaluation of using embryos, we developed a method based on OECD test guideline with aim improve efficiency. We used 4–128 cell stage embryos performed an exposure assay 96-well microtiter plate, observing lethality endpoints at 48-h postexposure. A total 32 chemicals...
The accurate delivery of precise amounts drugs to a specific location can considerably affect various clinical applications. control drug amount and position is crucial successful delivery. This paper proposes the use poly(lactide-co-glycolicacid) (PLGA)-based microspheres contain an optical tweezer manipulator transport these drug-containing their targeted sites in vivo. were delivered by PLGA-based yolk sac zebrafish embryos, sustained release was observed examine anti-angiogenesis...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)