Pascale Le Ruyet

ORCID: 0000-0003-0276-754X
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About
Contact & Profiles
Research Areas
  • Infant Nutrition and Health
  • Fatty Acid Research and Health
  • Muscle metabolism and nutrition
  • Diet and metabolism studies
  • Nutrition and Health in Aging
  • Gut microbiota and health
  • Probiotics and Fermented Foods
  • Reproductive Physiology in Livestock
  • Agriculture and Rural Development Research
  • Birth, Development, and Health
  • Breastfeeding Practices and Influences
  • Exercise and Physiological Responses
  • Digestive system and related health
  • Peroxisome Proliferator-Activated Receptors
  • Child Nutrition and Feeding Issues
  • Ruminant Nutrition and Digestive Physiology
  • Animal health and immunology
  • Infant Health and Development
  • Nutritional Studies and Diet
  • Muscle Physiology and Disorders
  • Diet, Metabolism, and Disease
  • Clinical Nutrition and Gastroenterology
  • Metabolism and Genetic Disorders
  • Sports Performance and Training
  • Bariatric Surgery and Outcomes

Périnatalité & Risques Toxiques
2010-2020

Nutrition & Santé (Spain)
2016

Centre de Recherche en Nutrition Humaine d'Auvergne
2015

Unité de Nutrition Humaine
2015

Institut de Recherche pour le Développement
2013

Laval Mayenne Technopole
2004-2008

Oklahoma State University
1992-1993

Mississippi State University
1992

Princeton Public Schools
1992

Institut National de la Recherche Agronomique
1984-1985

The postnatal period is a critical time window during which inflammatory events have significant and enduring effects on the brain, as consequence, induce alterations of emotional behavior and/or cognition later in life. However, long-term effect neonatal inflammation adolescence, sensitive for development neurodevelopmental psychiatric disorders, has been little studied. In this study, we examined whether an early-life challenge could alter behaviors spatial memory at adolescence adulthood...

10.1186/s12974-014-0155-x article EN cc-by Journal of Neuroinflammation 2014-09-16

Human milk is generally recognized as the gold standard in neonatal nutrition. The structure and composition of human are better mimicked infant formulas that include cow's lipids fat membrane extracts, which could also improve physiological properties. Nevertheless, very few use more expensive than vegetable lipids. potential impact lipid on digestive hydrolysis, intestinal physiology, gut microbiota was recently underlined by several scientific teams. In this context, purpose present...

10.1002/ejlt.201500025 article EN European Journal of Lipid Science and Technology 2015-07-15

Abstract Clinical and animal studies have demonstrated beneficial effects of early consumption dairy lipids a probiotic, Lactobacillus fermentum (Lf), on infant gut physiology. The objective this study was to investigate their long-term microbiota host entero-insular axis metabolism. Piglets were suckled with milk formula containing only plant (PL), half-half mixture (DL), or supplemented Lf (DL + Lf). They weaned standard diet challenged high-energy until postnatal day 140. DL modulated...

10.1038/s41598-018-29971-w article EN cc-by Scientific Reports 2018-07-30

Abstract Background Intestinal epithelial barrier ( IEB ) dysfunction plays a critical role in various intestinal disorders affecting infants and children, including the development of food allergies colitis. Recent studies highlighted probiotics regulating functions behavior adults, but their effects newborn remain largely unknown. We therefore characterized rat pups, impact Lactobacillus fermentum CECT 5716 (L. fermentum) on stress‐induced dysfunction, systemic immune response exploratory...

10.1111/nmo.13069 article EN Neurogastroenterology & Motility 2017-03-31

The effects of protein supplementation on muscle thickness, strength and fatigue seem largely dependent its composition. current study compared the soluble milk protein, micellar casein, a placebo during after resistance training program.Sixty-eight physically active men participated in this randomized controlled trial underwent 10 weeks lower-body training. Participants were randomly assigned to Placebo (PLA), Soluble Milk Protein (SMP, with fast digestion rate) or Micellar Casein (MC, slow...

10.1186/1550-2783-11-36 article EN cc-by Journal of the International Society of Sports Nutrition 2014-07-11

Growing evidence suggests that the consumption of dairy products may contribute to a reduced incidence cardiovascular risk factors, such as obesity, dyslipidemia, and type 2 diabetes. The fatty acid composition in milk fat, duration ripening, complexity food matrices are important factors interfere with physiological impact. In this study, we treated genetic obese diabetic mice (db/db) for 4 weeks different (cheese-based) products, differing by ripening (0, 15, or 35 days). We found days...

10.1021/jf204916x article EN Journal of Agricultural and Food Chemistry 2012-02-02

The purpose of this study was to investigate the effect whey supplementation, as compared standard casein diet, on recovery muscle functional properties after a casting-induced immobilization period. After an initial (I0) evaluation contractile plantarflexors (isometric torque-frequency relationship, concentric power-velocity relationship and fatigability test), ankle 20 male adult rats immobilized by casting for 8 days. During period, were fed diet with 13% (CAS). cast removal, received...

10.1371/journal.pone.0075408 article EN cc-by PLoS ONE 2013-09-19

The aim of the present study was to investigate effects a 8-week detraining period after 16-week multicomponent training program including strength and aerobic exercises on main determinants fitness, muscle some metabolic markers in 24 older subjects (60.2 ± 3.0 years). oxygen uptake at second ventilatory threshold (VO 2 V T2 ) end exercise 2max ), maximum voluntary contraction force (MVC) knee extensors indexes, i.e., insulin sensitivity, blood lipid profile, inflammatory cytokines,...

10.1139/h11-130 article EN Applied Physiology Nutrition and Metabolism 2012-02-01

When breastfeeding is not possible, infants are fed formulas (IF) in which lipids usually of plant origin. However, the use dairy fat combination with oils enables a lipid profile closer to breast milk terms fatty acid (FA) composition, triglyceride structure, polar and cholesterol contents. The objective this study was determine effect an IF containing mix on Omega-3 FA content red blood cells (RBC). This monocentric, double-blind, controlled, randomized trial. Healthy term were (D), (P) or...

10.1186/s12887-018-1047-5 article EN cc-by BMC Pediatrics 2018-02-13

As a concentrated source of saturated fat, cheese consumption is considered to be associated with increased cholesterolemia and generally forbidden in dietary guidelines for adults hypercholesterolemia. The aim this study was evaluate the impact fatty acids on lipid parameters blood pressure regards different types dairy products: Camembert full-fat yoghurt. One-hundred fifty-nine moderate hypercholesterolemic subjects without treatment were instructed consume two yoghurts (2 × 125 g) per...

10.3109/09637486.2014.945156 article EN International Journal of Food Sciences and Nutrition 2014-08-06

The objective of the present study was to evaluate consequence Camembert consumption on composition and metabolism human intestinal microbiota. cheese compared with milk fermented by yoghurt starters Lactobacillus casei as a probiotic reference. experimental model microbiota-associated (HM) rat. HM rats were fed basal diet (HMB group), containing made from pasteurised (HMCp group) or (HMfm group). level micro-organisms dairy products measured in faeces using cultures specific medium...

10.1079/bjn20041192 article EN British Journal Of Nutrition 2004-09-01

Human milk is the optimal nutrition for infants. When breastfeeding not possible, supplementation of infant formula with long chain polyunsaturated fatty acids appears to promote neurodevelopmental outcome and visual function. Plant oils, that are only source fat in most formulas, do contain specific present human cow encounter triglyceride structure. Experimental data suggest a mix dairy lipids plant oils can potentiate endogenous synthesis n-3 acids. This trial aims determine effect an...

10.1186/1471-2431-12-164 article EN cc-by BMC Pediatrics 2012-10-17

Scope One strategy to manage malnutrition in older patients is increase protein and energy intake. Here, we evaluate the influence of quality during refeeding on improvement muscle metabolism. Methods results Twenty‐month‐old male rats ( n = 40) were fed 50% their spontaneous intake for 12 weeks induce malnutrition, then refed ad libitum with a standard diet enriched casein or soluble milk proteins (22%) 4 weeks. A 13C‐valine was infused measure synthesis expression MuRF1, MAFbx measured...

10.1002/mnfr.201700287 article EN Molecular Nutrition & Food Research 2017-07-31
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