A5003496949- Muscle Physiology and Disorders
- Extracellular vesicles in disease
- Diabetes Treatment and Management
- Virus-based gene therapy research
- RNA Research and Splicing
- Pancreatic function and diabetes
- Mesenchymal stem cell research
- Cardiovascular Disease and Adiposity
- Diabetes Management and Research
Bar-Ilan University
2015-2019
Diabetes mellitus is a chronic metabolic disease, characterized by high blood glucose levels, affecting millions of people around the world. Currently, main treatment for diabetes requires multiple daily injections insulin and self-monitoring which markedly affect patients' quality life. In this study we present novel strategy controlled prolonged regulation, based on administration insulin-coated gold nanoparticles (INS-GNPs). We show that both intravenous subcutaneous injection INS-GNPs...
Abstract Duchenne muscular dystrophy (DMD) is a progressive, lethal, X-linked disease of skeletal and cardiac muscles caused by mutations in the dystrophin gene. Loss leads to muscle fiber damage impairment satellite cell asymmetric division, which are essential for regeneration. These processes ultimately result wasting replacement degenerating fibrogenic cells, process that generation fibrotic tissues. Preimplantation factor (PIF) an evolutionary conserved 15-amino acid peptide secreted...