Alexandria Lee

ORCID: 0000-0003-0288-1270
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About
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Research Areas
  • Hemodynamic Monitoring and Therapy
  • Effects and risks of endocrine disrupting chemicals
  • Sepsis Diagnosis and Treatment
  • Infant Nutrition and Health
  • Ovarian cancer diagnosis and treatment
  • Reproductive Biology and Fertility
  • Climate Change and Health Impacts
  • Ovarian function and disorders
  • Viral gastroenteritis research and epidemiology
  • Immune Response and Inflammation
  • Trauma, Hemostasis, Coagulopathy, Resuscitation

Harvard University
2021-2022

United States Department of Health and Human Services
2022

University of California, Los Angeles
2018

Children's Hospital of Los Angeles
2014

Parental preconception exposure to select phenols and phthalates was previously associated with increased risk of preterm birth in single chemical analyses. However, the joint effect phenol phthalate mixtures on is unknown. We included 384 female 211 male (203 couples) participants seeking infertility treatment Environment Reproductive Health (EARTH) Study who gave singleton infants between 2005 2018. Mean urinary concentrations bisphenol A (BPA), parabens, eleven biomarkers, including...

10.1016/j.envint.2021.106440 article EN cc-by-nc-nd Environment International 2021-02-25

Sepsis is a leading cause of morbidity and mortality worldwide characterized by vascular leak. Treatment for sepsis, specifically intravenous fluids, may worsen deterioration in the context We therefore sought to quantify leak sepsis patients guide fluid resuscitation.

10.1186/s13054-022-03968-4 article EN cc-by Critical Care 2022-04-11

Although parental preconception exposure to some phenols and phthalates have been associated with reduced birthweight, few studies examined these chemicals as complex mixtures.We included 384 mothers 211 fathers (203 couples) who gave birth singletons from a prospective cohort of couples seeking fertility evaluation. Urinary concentrations bisphenol A (BPA), parabens, 11 phthalate metabolites including those di(2-ethylhexyl) (DEHP) were examined. Birthweight was abstracted delivery records....

10.1097/ee9.0000000000000222 article EN cc-by-nc-nd Environmental Epidemiology 2022-08-31

ABSTRACT Purpose Sepsis is a leading cause of morbidity and mortality worldwide characterized by vascular leak syndrome. Treatment for sepsis, specifically intravenous fluids, may worsen deterioration in the context leak. Methods We performed retrospective cohort study sepsis patients four ICU databases North America, Europe, Asia. developed an intuitive index (VLI) determined relationship between VLI in-hospital death 36h-84h fluid balance using generalized additive models (GAM). Results...

10.1101/2021.08.22.21262080 preprint EN cc-by-nc-nd medRxiv (Cold Spring Harbor Laboratory) 2021-08-30
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