A5077441091- Breast Lesions and Carcinomas
- Monoclonal and Polyclonal Antibodies Research
- Breast Cancer Treatment Studies
- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Spinal Fractures and Fixation Techniques
- Global Cancer Incidence and Screening
- Advanced Biosensing Techniques and Applications
- Pelvic and Acetabular Injuries
- Traumatic Brain Injury and Neurovascular Disturbances
- Cancer and Skin Lesions
- Radiomics and Machine Learning in Medical Imaging
- Spinal Hematomas and Complications
- Radiation Dose and Imaging
- Orthopedic Infections and Treatments
- Phytoestrogen effects and research
- Patient-Provider Communication in Healthcare
- Radiopharmaceutical Chemistry and Applications
- Autoimmune Neurological Disorders and Treatments
- MRI in cancer diagnosis
- Sarcoidosis and Beryllium Toxicity Research
- Hops Chemistry and Applications
- Neuroscience of respiration and sleep
- Intracerebral and Subarachnoid Hemorrhage Research
- Interpreting and Communication in Healthcare
Mater Misericordiae University Hospital
2013-2023
Avacta (United Kingdom)
2018-2019
Stanley Foundation
2017
Western General Hospital
2000-2008
<h3>BACKGROUND AND PURPOSE:</h3> Multiphase CTA, a technique to dynamically assess the vasculature in acute ischemic stroke, was primarily developed evaluate collateral filling. We have observed that it is also useful identifying distal anterior circulation occlusions due delayed opacification on multiphase an observation we term “delayed vessel sign.” aimed determine usefulness of this sign by comparing CTA with single-phase CTA. <h3>MATERIALS METHODS:</h3> All 23 during 2-year period were...
This study aimed to assess the effect of sensory stimulation on patient MRI experience and whether has a significant MR image quality.A case-control was conducted over 4 months, involving patients undergoing brain, cervical spine, breast prostate. The involved 106 patients, 64 cases 42 controls. Cases underwent during scan in form scented cotton pad placed scanner near their head and/or calming bird noises were played headphones. Post-scan, participants completed questionnaire regarding MRI....
Abstract Injected drug use is associated with a wide range of medical complications which are predominantly musculoskeletal and vascular in nature. Illicit increasing worldwide. Patients injected often present non-specific manner without reliable clinical history. Musculoskeletal typically infective aetiology may vary widely severity from mild to life-threatening. A multimodal imaging approach required for both diagnostic image-guided sampling. Plain radiographs an important initial test,...
Increasing numbers of patients and carers rely on online resources for healthcare information. Radiation safety can be misunderstood by clinicians lead to patient anxiety. We aimed assess the readability educational materials (PEMs) related radiation safety.
Basal cell carcinoma (BCC) is the most common non-melanomatous skin cancer, typically arising in sun-exposed areas such as head and neck. Defective signaling through Hedgehog (HH) pathway forms molecular basis for BCC. Surgery remains mainstay of treatment. genital tract rare metastatic We report a case BCC young woman with previously resected vulval presenting six years later inguinal nodal recurrence multiple lung metastases.
Abstract The presence of tertiary lymphoid structures (TLS) and associated high endothelial venules (HEV) in the tumor microenvironment strongly correlates with improved prognosis treatment outcomes across a wide range solid tumors. These clinical observations, now replicated repeatedly, highlight therapeutic potential induction TLS and/or boosting functions, which include acting as point entry education for immune effector cells locally tumor. Lymphotoxin beta receptor (LTBR) signalling is...
Twenty patients with cyclical breast pain were enrolled in a double-blind cross-over trial which either soy protein drink or flavoured cow's milk was taken orally each day for 3 months before crossing over to the alternate further months. Records of scores throughout study. Blood also and after 6 measurement phytoestrogents assess compliance. Two women withdrew from study at outset leaving 18 evaluable who completed Of these 10 (56%) felt that improved (two whom received as first treatment)...
The Pharmacy Department at the Western General Hospital in Edinburgh prepares a topically applied product which morphine sulphate is incorporated into Instillagel for use reducing pain associated with rectal and other cancers. A stability indicating method was required assessment of this combination.A gradient high performance liquid chromatography developed to assess an LC-MS used characterize degradants from forced degradation components formulation.The found have acceptable inter-...
Encephalopathy associated with autoimmune thyroid disease (EAATD), also known as Hashimoto's encephalopathy, is a rare neurological condition that may occur in patients clinical or sub-clinical disease. The pathogenesis of EAATD has been not clearly elucidated yet. diagnostic criteria include psychiatric symptoms, high levels anti-thyroid antibodies, and exclusion other possible causes encephalopathy. In the large majority cases, respond to immunosuppressant therapies, particular...
Acetabular paralabral cysts are common. They vary in their clinical presentation and may be asymptomatic or cause pain restriction at the hip joint. In rare instances they symptoms by compressing local neurovascular structures. We report a case of symptomatic compression sciatic nerve posteriorly displaced acetabular cyst.
Thyroid radiation shields are often uncovered by the surgical gown and may represent a preventable source of wound contamination. The aims this study to define common pathogens found on thyroid evaluate effectiveness simple cleaning method.Samples were obtained from 29 community collected operating theatres 3 teaching hospitals. Each shield was swabbed under strict sterile technique using separate swab for each 4 designated zones. After sampling, cleaned with readily available disinfectant...
Abstract We have generated a range of potent Affimer antagonists to both human and mouse programmed death-ligand 1 (PD-L1) demonstrated that when formatted, possess the necessary affinity, pharmacokinetics (PK) tissue penetration modulate immune system demonstrate efficacy in models. biotherapeutics are new protein scaffold with great potential for generation biotherapeutics. Based on protease inhibitor Stefin A, is small (12kDa), lacks any post translational modifications such as disulphide...
Abstract Programmed Cell Death-Ligand 1 (PD-L1) binds to its receptor, Death protein (PD-1) and is expressed on a range of activated immune cells upregulated by tumor in the microenvironment. PD-L1 immunotherapies have emerged as effective treatments both monotherapies combinations, providing long term responses subset patients. Phage display selections identified potent Affimer biotherapeutic antagonists human mouse programmed death-ligand (PD-L1). We demonstrated when formatted bivalent...