A5102997865- Cancer Treatment and Pharmacology
- Chemotherapy-induced cardiotoxicity and mitigation
- Breast Cancer Treatment Studies
- Advanced Breast Cancer Therapies
- HER2/EGFR in Cancer Research
- Cardiac Imaging and Diagnostics
- Neutropenia and Cancer Infections
- Estrogen and related hormone effects
- Cancer survivorship and care
- Cancer Diagnosis and Treatment
- Health Systems, Economic Evaluations, Quality of Life
- PI3K/AKT/mTOR signaling in cancer
- Cardiovascular Function and Risk Factors
- Bone health and treatments
- Advances in Oncology and Radiotherapy
- BRCA gene mutations in cancer
- Cancer-related Molecular Pathways
- Breast Lesions and Carcinomas
- Angiogenesis and VEGF in Cancer
- Takotsubo Cardiomyopathy and Associated Phenomena
- Male Breast Health Studies
- Economic and Financial Impacts of Cancer
- Metabolism, Diabetes, and Cancer
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
University of Rochester
2024-2025
Duke University
2019-2025
Twitter (United States)
2025
University of Pittsburgh
2022
Ottawa Hospital
2012-2021
University of Ottawa
2012-2021
Ottawa Hospital Research Institute
2012-2021
Ottawa Regional Cancer Foundation
2004-2020
Toronto Public Health
2018
Virginia Cancer Specialists
2017
Purpose Cardiac dysfunction is a serious adverse effect of certain cancer-directed therapies that can interfere with the efficacy treatment, decrease quality life, or impact actual survival patient cancer. The purpose this effort was to develop recommendations for prevention and monitoring cardiac in survivors adult-onset cancers. Methods Recommendations were developed by an expert panel multidisciplinary representation using systematic review (1996 2016) meta-analyses, randomized clinical...
In recent years, patients have indicated a desire for more information about their disease and to be involved in making decisions care. We developed an aid called the "Decision Board" help clinicians inform with lymph node-negative breast cancer of risks benefits adjuvant chemotherapy. determined whether adding Decision Board medical consultation improved patient knowledge satisfaction compared alone.Between October 1995 March 2000, 176 women who were candidates chemotherapy randomly...
Quality indicators (QIs) are tools designed to measure and improve quality of care. The objective this study was assess stakeholder acceptability QIs end-of-life (EOL) care that potentially were measurable from population-based administrative health databases.After a literature review, the authors identified 19 candidate through databases. A modified Delphi methodology, consisting multidisciplinary panels cancer professionals in Nova Scotia Ontario, used agreement on acceptable EOL (n = 21...
Purpose: Most male breast cancer tumours are hormone receptor–positive; the patients therefore receive endocrine therapy. There is, however, a paucity of published data on toxicities experienced by who prescribed In present study, we examined rates adherence to and toxicity from treatments in treated at single institution. Patients Methods: We conducted retrospective study diagnosed with The Ottawa Hospital Cancer Centre during 1981–2003. Data collected included patient age, receptor status,...
Our objective was to evaluate preferences associated with grade I/II and III/IV chemotherapy side effects among breast cancer patients receiving chemotherapy. We also assessed trade-offs that are willing make between treatment the route schedule of administration.In this cross-sectional study, for completed a one-time Web survey. Conjoint analysis used elicit 17 available chemotherapies regimens. In analysis, risk each effect increased by 5%, holding all others constant, respective impact on...
The authors conclude that emergency room visits and hospitalization are common among patients with early breast cancer receiving chemotherapy significantly higher than controls.
PURPOSE Preclinical studies indicate that metronomic chemotherapy is antiangiogenic and synergistic with other agents. We designed a phase I/II study to evaluate the safety activity of adding dalteparin prednisone cyclophosphamide methotrexate in women measurable metastatic breast cancer (MBC). PATIENTS AND METHODS Patients received daily oral cyclophosphamide, twice-weekly methotrexate, (dalCMP). The primary end point was clinical benefit rate (CBR), combination complete response (CR),...
LBA671 The full, final text of this abstract will be available at abstract.asco.org 12:01 AM (EDT) on Sunday, June 3, 2012, and in the Annual Meeting Proceedings online supplement to 20, issue Journal Clinical Oncology. Onsite Meeting, printed Sunday edition ASCO Daily News.
Abstract Purpose. Angiogenesis is an important hallmark of breast cancer growth and progression. Pazopanib, oral small molecule inhibitor vascular endothelial factor receptor, platelet-derived KIT, has activity across a range solid tumors. We evaluated the single-agent pazopanib in recurrent or metastatic (MBC). Patients Methods. with MBC, treated up to two prior lines chemotherapy, were eligible receive pazopanib, 800 mg daily until The primary endpoint was objective response rate as...
Cardiotoxicity from anthracycline-based chemotherapy is an important cause of early and late morbidity mortality in breast cancer patients. Left ventricular (LV) function assessed for patients receiving to identify cardiotoxicity. However, animal studies suggest that right (RV) may be a more sensitive measure detect LV dysfunction. The purpose this pilot study was determine if undergoing experience RV dysfunction.Forty-nine at the Ottawa Hospital between November 2007 March 2013 who had 2...
Despite the use of standardized anti-emetic guidelines, up to 20% cancer patients suffer from moderate-to-severe chemotherapy-induced nausea and vomiting (cinv)-that is, grade 2 or greater according U.S. National Cancer Institute Common Terminology Criteria for Adverse Events, version 4.0. We previously developed cycle-based prediction models associated scoring systems acute delayed cinv. As part validation process, we prospectively evaluated ability accurately identify deemed be high risk...
The Breast Cancer Disease Site Group of Care Ontario identified the need for new guidelines adjuvant systemic therapy early-stage breast cancer. specific question to be addressed was "What is optimal female patients with operable cancer, when patient and disease factors are considered?" A systematic review prepared based on literature searches conducted using medline embase databases period January 2008 March 5, 2012, updated May 12, 2014. Guidelines were located from that search, Standards...
Abstract Objective To evaluate the effectiveness of remote proactive management toxicities during chemotherapy for early stage breast cancer. Design Pragmatic, cluster randomised trial. Setting 20 cancer centres in Ontario, Canada, allocated by covariate constrained randomisation to or routine care. Participants All patients starting adjuvant neoadjuvant at each centre. 25 from centre completed patient reported outcome questionnaires. Interventions Proactive, standardised, nurse led...