A5030239845- Breast Cancer Treatment Studies
- Radiomics and Machine Learning in Medical Imaging
- AI in cancer detection
- MRI in cancer diagnosis
- Ultrasound and Hyperthermia Applications
- Cancer Treatment and Pharmacology
- Global Cancer Incidence and Screening
- Photoacoustic and Ultrasonic Imaging
- Cancer survivorship and care
- Breast Lesions and Carcinomas
- Ultrasound Imaging and Elastography
- HER2/EGFR in Cancer Research
- Advanced Breast Cancer Therapies
- Neutropenia and Cancer Infections
- Medical Imaging Techniques and Applications
- Cancer Genomics and Diagnostics
- Palliative Care and End-of-Life Issues
- Multiple and Secondary Primary Cancers
- Economic and Financial Impacts of Cancer
- Cancer Immunotherapy and Biomarkers
- Estrogen and related hormone effects
- Ocular Surface and Contact Lens
- Childhood Cancer Survivors' Quality of Life
- Medication Adherence and Compliance
- Colorectal Cancer Screening and Detection
Health Sciences Centre
2015-2025
Sunnybrook Health Science Centre
2016-2025
University of Toronto
2013-2025
Sunnybrook Research Institute
2021-2024
Delhi Technological University
2023-2024
Mayo Clinic
2024
Mayo Clinic in Arizona
2024
Icahn School of Medicine at Mount Sinai
2023
Johns Hopkins University
2021-2022
Johns Hopkins Bayview Medical Center
2021-2022
Diagnostic errors contribute to patient harm, though few data exist describe their prevalence or underlying causes among medical inpatients.
We determined whether nucleases are deficient in the tear fluid of dry eye disease (DED) patients, and this causes extracellular DNA (eDNA) neutrophil trap (NET) accumulation precorneal film, thus causing ocular surface inflammation.Exfoliated cells adhered to Schirmer test strips were collected on glass slides, immunofluorescence confocal microscopy was used evaluate neutrophils, eDNA, NETs, their molecular components. Similar experiments performed with mucoid films from inferior...
In Brief OBJECTIVE: To investigate the relationship of health literacy and screening mammography. METHODS: All patients seen at a breast clinic underwent prospective assessment from January 2010 to April 2013. women least 40 years age were included. Men diagnosed with cancer before excluded. Routine was performed using Newest Vital Sign. Demographic data also collected. Medical records reviewed determine if had undergone mammography: aged 40–49 considered have they another mammogram within 2...
Earlier goals of care (GOC) discussions in patients with advanced cancer are associated less aggressive end-of-life including decreased use medical technologies. Unfortunately, conversations often occur late the disease trajectory when acutely unwell. Here, we evaluate practitioner perspectives patient, family, physician, and external barriers to early GOC ambulatory oncology setting.A previously published survey assess among clinicians on inpatient wards was modified for setting distributed...
Abstract Background This study was conducted in order to develop a model for predicting response neoadjuvant chemotherapy (NAC) patients with locally advanced breast cancer (LABC) using pretreatment quantitative ultrasound (QUS) radiomics. Methods multicenter involving four sites across North America, and appropriate approval obtained from the individual ethics committees. Eighty‐two LABC were included final analysis. Primary tumors scanned clinical system before NAC started. The contoured,...
Neoadjuvant chemotherapy (NAC) is used to treat locally advanced breast cancer (LABC) and high-risk early (BC). Pathological complete response (pCR) has prognostic value depending on BC subtype. Rates of pCR, however, can be variable. Predictive modeling desirable help identify patients who may have suboptimal NAC response. Here, we test compare the predictive performances machine learning (ML) prediction models a standard statistical model, using clinical pathological data.Clinical...
Preclinical studies have demonstrated that tumour cell death can be enhanced 10- to 40-fold when radiotherapy is combined with focussed ultrasound-stimulated microbubble (FUS-MB) treatment. The acoustic exposure of microbubbles (intravascular gas microspheres) within the target volume causes bubble cavitation, which induces perturbation vasculature and activates endothelial apoptotic pathways responsible for ablative effect stereotactic body radiotherapy. Subsequent irradiation a...
// Ali Sadeghi-Naini 1,2,3,4 , Lakshmanan Sannachi Kathleen Pritchard 5 Maureen Trudeau Sonal Gandhi Frances C. Wright 6,7 Judit Zubovits 8 Martin J. Yaffe 1,3 Michael Kolios 3,9 Gregory Czarnota 1 Imaging Research - Physical Sciences, Sunnybrook Institute, Health Sciences Centre, Toronto, ON, Canada 2 Department of Radiation Oncology, Odette Cancer 3 Medical Biophysics, Faculty Medicine, University 4 and 6 Division General Surgery, 7 Pathology, 9 Physics, Ryerson University, Correspondence:...
Abstract Anti-cancer therapies including chemotherapy aim to induce tumour cell death. Cell death introduces alterations in morphology and tissue micro-structures that cause measurable changes echogenicity. This study investigated the effectiveness of quantitative ultrasound (QUS) parametric imaging characterize intra-tumour heterogeneity monitor pathological response breast cancer a large cohort patients (n = 100). Results demonstrated QUS can non-invasively outcome early following...
Background Pathological response of breast cancer to chemotherapy is a prognostic indicator for long-term disease free and overall survival. Responses locally advanced in the neoadjuvant (NAC) settings are often variable, prediction imperfect. The purpose this study was detect primary tumor responses early after start using quantitative ultrasound (QUS), textural analysis molecular features patients with cancer. Methods included ninety six treated chemotherapy. Breast tumors were scanned...
Background Neoadjuvant chemotherapy (NAC) is the standard of care for patients with locally advanced breast cancer (LABC). The study was conducted to investigate utility quantitative ultrasound (QUS) carried out during NAC predict final tumour response in a multi-institutional setting. Methods Fifty-nine LABC were enrolled from three institutions North America (Sunnybrook Health Sciences Centre (Toronto, Canada), MD Anderson Cancer (Texas, USA), and Princess Margaret Canada)). QUS data...
<h3>Background:</h3> High rates of health care utilization at the end life may be a marker that does not align with patient-stated preferences. We sought to describe trends in end-of-life and factors associated dying hospital. <h3>Methods:</h3> conducted population-level retrospective cohort study adult decedents Ontario between Apr. 1, 2004, Mar. 31, 2015, using linked administrative data sets, including Office Registrar General for Deaths database, hospital Discharge Abstract Database,...
Abstract Objective To evaluate the effectiveness of remote proactive management toxicities during chemotherapy for early stage breast cancer. Design Pragmatic, cluster randomised trial. Setting 20 cancer centres in Ontario, Canada, allocated by covariate constrained randomisation to or routine care. Participants All patients starting adjuvant neoadjuvant at each centre. 25 from centre completed patient reported outcome questionnaires. Interventions Proactive, standardised, nurse led...
Abstract Preclinical studies have demonstrated focused ultrasound (FUS) stimulated microbubble (MB) rupture leads to the activation of acid sphingomyelinase-ceramide pathway in endothelial cells. When radiotherapy (RT) is delivered concurrently with FUS-MB, apoptotic increased cell death resulting potent radiosensitization. Here we report first human trial using magnetic resonance imaging (MRI) guided FUS-MB treatment breast malignancies. In phase 1 prospective interventional study, patients...
The purpose of this study was to describe identifiers and estimate maternal neonatal outcomes in women who attempt suicide during pregnancy.A linked Vital Statistics-Patient Discharge database the State California used identify cases intentional injury pregnancy. A retrospective analysis pregnant were admitted for attempted is presented.There 4,833,286 deliveries from 1991 1999. Of those deliveries, 2,132 complicated by pregnancy (0.4 per 1,000 pregnancies). control population composed...
The Breast Cancer Disease Site Group of Care Ontario identified the need for new guidelines adjuvant systemic therapy early-stage breast cancer. specific question to be addressed was "What is optimal female patients with operable cancer, when patient and disease factors are considered?" A systematic review prepared based on literature searches conducted using medline embase databases period January 2008 March 5, 2012, updated May 12, 2014. Guidelines were located from that search, Standards...
Diffuse optical spectroscopy (DOS) has been demonstrated capable of monitoring response to neoadjuvant chemotherapy (NAC) in locally advanced breast cancer (LABC) patients. In this study, we evaluate texture features pretreatment DOS functional maps for predicting LABC NAC.Locally patients (n=37) underwent imaging before starting NAC. Breast tissue parametric were constructed and analyses performed based on grey-level co-occurrence matrices feature extraction. Ground truth labels as...
Strain elastography was used to monitor response neoadjuvant chemotherapy (NAC) in 92 patients with biopsy-proven, locally advanced breast cancer. data were collected before, during, and after NAC. Relative changes tumor strain ratio (SR) calculated over time, responder status classified according size changes. Statistical analyses determined the significance of SR time between groups. Machine learning techniques, such as a naïve Bayes classifier, evaluate performance marker for Miller-Payne...