A5014001221- Poisoning and overdose treatments
- Pharmacy and Medical Practices
- Pharmacological Effects of Natural Compounds
- Cardiac Arrest and Resuscitation
- Suicide and Self-Harm Studies
- Safe Handling of Antineoplastic Drugs
- Pediatric health and respiratory diseases
- Salivary Gland Disorders and Functions
- Consumer Attitudes and Food Labeling
- Nerve injury and regeneration
- Advanced Drug Delivery Systems
- Antifungal resistance and susceptibility
- Drug-Induced Adverse Reactions
- Protein Hydrolysis and Bioactive Peptides
- Pain Mechanisms and Treatments
- Enzyme Production and Characterization
- ATP Synthase and ATPases Research
- Drug Solubulity and Delivery Systems
- Pharmaceutical studies and practices
- Antimicrobial Peptides and Activities
- Oral Health Pathology and Treatment
- Herbal Medicine Research Studies
- Tracheal and airway disorders
- Synthesis of β-Lactam Compounds
- Geology and Paleoclimatology Research
Teikyo University
2012-2025
Teikyo University Hospital
2007
University of Tsukuba Hospital
2003
Hamamatsu University School of Medicine
2003
University of Tokyo Hospital
2000-2002
The University of Tokyo
1992-2002
Nitobe Memorial Nakano General Hospital
2002
Fukushima Medical University Hospital
2000
Aoyama Gakuin University
1998-1999
Pharmacists who provide medication to patients immediately before they overdose should intervene appropriately; however, little information exists on the types and amounts of over-the-counter (OTC) drugs that are dangerous. This study investigated toxicity characteristics overdosing a single package commercially available OTC in humans. We researched 14,107 drugs. The number products could contain lethal dose if taken as was 1,223 (8.7%) toxic 2,982 (21.1%). A product containing humans by...
Although Janus kinase (JAK) inhibitors have expanding indications, deep vein thrombosis (DVT) and pulmonary embolism (PE) are serious adverse events associated with their use. Moreover, analysis using the Japanese database of spontaneous drug reaction reports has not yet been conducted. The objective this study was to analyze Adverse Drug Event Report (JADER) evaluate association between JAK DVT PE. JADER from April 2004 October 2023 were analyzed. A classification for period covered...
Abstract Background Food is known to affect drug absorption by delaying gastric emptying time, altering gastrointestinal pH, stimulating bile flow, increasing splanchnic blood or physically interacting with drugs. Although food the pharmacokinetics of oral antineoplastic drugs, relationship between effects and physicochemical properties drugs remains unclear. Methods In this study, we surveyed literature on three kinds pharmacokinetic changes, AUC ratio, C max ratio T in fasted fed state for...
Patients with Sjögren's syndrome (SS) typically present clinically xerostomia (dry mouth) because of progressive damage to the exocrine glands. We developed a new, low-dose pilocarpine/sodium alginate (LPA) solution pilocarpine hydrochloride inhibit systemic adverse effects by administering via oral mucosa. The purpose this study was assess its stability, safety, and efficacy.The concentration in an LPA liquid formulation measured 3, 7, 14, 28 days after preparation stability. A prospective...
Clonidine hydrochloride has been used for pre-anesthetic medication to provide a pre-operative sedation in pediatric surgery. The purpose of this study is determine the plasma clonidine concentration, which gives satisfactory Sixteen patients (age: 1—11 years, weight: 9—33 kg) received either 2 or 4 μg/kg lollipop before entering operating room. Plasma concentrations were determined 120 min after administration lollipop. Pre-operative was evaluated by 5-point scoring systems at changes...
The intestinal bacteria, Eubacterium sp. and Bifidobacterium sp., participate in the metabolism of active kampo-ingredients, glycyrrhizin (GL), sennoside (SEN) baicalin (BL). Since antibiotics bacterial preparations, longum (LAC-B®), Clostridium butyricum (MIYA-BM®), Streptococcus faecalis (BIOFERMIN®), affect population flora, kampo-ingredients flora may be altered by their combined administration. We investigated 1199 prescriptions including kampo-medicines for 308 patients. Combination...
Information on milk transferability of drugs is important for patients who wish to breastfeed. The purpose this study develop a prediction model milk-to-plasma drug concentration ratio based area under the curve (M/PAUC). quantitative structure-activity/property relationship (QSAR/QSPR) approach was used predict compounds involved in active transport during transfer.We collected M/P data from literature, which were curated and divided into M/PAUC ≥ 1 < 1. Using ADMET Predictor® Modeler™, we...
Enalapril is an antihypertensive medicine that inhibits angiotensin I-converting enzyme (ACE). The present study investigated interactions between enalapril and a fermented milk product (FMP) containing the ACE-inhibitory peptides, Val-Pro-Pro (VPP) Ile-Pro-Pro (IPP).Single-dose long-term (6-week) in vivo studies were used to investigate effects of FMP on blood pressure spontaneously hypertensive rats.Single-dose oral administration concomitant (VPP, IPP: 3.5 mg/kg) produced lower effect...
To develop a new mucoadhesive film containing an analgesic combining clinical efficacy and patient comfort, we prepared evaluated two-layered consisting of adhesive layer indomethacin (IM) as the active ingredient carboxyvinyl polymer (CP) bonding agent nonadhesive polyethylene glycol (PEG) to improve texture. In in vitro vivo tests, optimal concentration CP that could be applied mucous membrane was 0.2% or 0.3%. Stability testing determined storage conditions expiration period were 4°C...
The expression of phosphatidylserine-specific phospholipase A 1 (PS-PLA ) is most upregulated in the genes peripheral blood cells from chronic rejection model rats bearing long-term surviving cardiac allografts. profile PS-PLA responsible for immune response may indicate a possible biological marker episodes. In this study, mRNA was examined human THP-1-derived macrophages. effects several immunosuppressive agents on were also vitro experiments. real-time RT-PCR analysis revealed that found...
Tracheal intubation may be performed in patients with drug overdose due to self-harm; however, the details of causative are unknown. The purpose this study was clarify relationship between drugs or its blood levels and need for tracheal based on actual measurement results.From October 2018 March 2020, 132 self-harm who were transported emergency department (ED) studied. Patient measured using gas chromatography-mass spectrometry (GC-MS) analyzed basis GC/MS Forensic Toxicological Database....
Overdose has become a global social problem. The Japanese government requires gatekeeper training to detect and prevent indicators of overdose suicide. However, knowledge necessary factors for the (patient intervention) is limited. This study aimed investigate characteristics individuals who experienced intervening persons expected overdose, identify required gatekeepers. A Google form was used survey 298 pharmacists registered sellers in Japan. We searched by logistic analysis. Knowledge...
Journal Article Molecular Cloning, Expression, and Site-Directed Mutagenesis of Inorganic Pyrophosphatase from Thermus thermophilus HB8 Get access Takanori Satoh, Satoh *Department Chemistry, College Science Engineering, Aoyama Gakuin UniversityChitosedai, Setagaya-ku, Tokyo 157-8572 2 Tel: +81-3-5384-1111 (Ext. 3204), Fax: +81-3-5384-6200, E-mail: samejima@candy.chem.aoyama.ac.jp Search for other works by this author on: Oxford Academic PubMed Google Scholar Machiko Watanabe, Watanabe...
In order to estimate predisposing activity of oral application beclomethasone dipropionate (BDP)-containing mucoadhesive films for candidiasis, the effects BDP on growth Candida albicans were examined in vivo and vitro. Murine neutrophils inhibited mycelial C. vitro, but this anti-Candida was clearly suppressed by presence 10−6 M BDP. a BDP-release test showed that amount released from BDP-containing into fluid phase increased time- concentration-dependent manner reached about 10—15% total...
Abstract The combination effects of chloroquine with a mixture febrifugine and isofebrifugine were evaluated against blood‐induced infection chloroquine‐resistant P. berghei NK65 in ICR mice. Mice the untreated control showed progressively increasing parasitemia leading to mouse death. A two‐day dosage 20 mg base/kg alone little effect infection, all mice died from day 13 14 an parasitemia. four‐day 1 mg/kg antimalarial activity, but 19 27 On other hand, treated plus alkaloids survived...
To develop a film formulation allowing controlled release for long-term analgesia, we selected ethyl cellulose (EC) as novel additive, prepared using indomethacin (IM film), and evaluated it in vitro clinically. In the experiments, effects of EC concentration on rate IM adhesion force to mucous membrane were investigated. The addition 10% resulted more sustained slow compared with no EC, added was similar that films containing carboxyvinyl polymer, which reported previously showed...
We have developed a compact gravimeter for measurement on board an AUV called R-One Robot. The gravity sensor is special model of Scintrex CG-3M with operating range 27 gals. stabilized signals from optical gyroscope. has been tested and examined diagnostic table surface ships anchored in harbor as well the Resolution gravimetry order 1 mgal (10/sup -6/ G); few problems remain to be solved.
After meropenem hydrate (MEPM) injection and amino acid infusions are mixed, the MEPM residual ratio sequentially decreases. This incompatibility is probably due to nucleophilic attack on β-lactam ring of by L-cysteine (L-Cys) present in infusion. study aims identify influence L-Cys reaction between through an initial test at pH 4 8, followed (MEPM plus additives) 18 types infusions. In test, as increased, decomposition speed was observed increase after mixing two components. progressed a...