A5084590167- Acute Lymphoblastic Leukemia research
- Childhood Cancer Survivors' Quality of Life
- Radiation Dose and Imaging
- Lymphoma Diagnosis and Treatment
- Effects of Radiation Exposure
- Chronic Myeloid Leukemia Treatments
- Oral health in cancer treatment
- Advanced Radiotherapy Techniques
- Neuroblastoma Research and Treatments
- Glioma Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Global Cancer Incidence and Screening
- Inflammatory Bowel Disease
- Data-Driven Disease Surveillance
- Epigenetics and DNA Methylation
- Neonatal Health and Biochemistry
- Radioactivity and Radon Measurements
- Cancer Genomics and Diagnostics
- Radiation Therapy and Dosimetry
- Renal Transplantation Outcomes and Treatments
- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Environmental Justice and Health Disparities
- Retinoids in leukemia and cellular processes
- Neutropenia and Cancer Infections
Tampere University Hospital
2018-2025
Tampere University
2016-2025
Kanta-Hämeen Keskussairaala
2022-2023
Danish Cancer Society
2020
National and Kapodistrian University of Athens
2020
Radiation and Nuclear Safety Authority
2019
University of Eastern Finland
2019
Urho Kaleva Kekkonen Institute
2019
High doses of ionizing radiation are an established cause childhood leukemia. However, substantial uncertainty remains about the effect low radiation, including background and potential differences between genetic subgroups leukemia have rarely been explored. We investigated gamma on using a nationwide register‐based case‐control study. For each 1,093 cases, three age‐ gender matched controls were selected ( N = 3,279). Conditional logistic regression analyses adjusted for confounding by...
The only well-established risk factors for childhood leukemia are high-dose ionizing radiation and Down syndrome. Computerized tomography is a common source of low-dose radiation. In this study, we examined the magnitude after pediatric computed examinations. We evaluated association scans with in nationwide register-based case-control study. Cases (n=1,093) were identified from population-based Finnish Cancer Registry three controls, matched by gender age, randomly selected each case...
Abstract Purpose Acute leukemia is the most common childhood malignancy, with suspected contributions from environmental factors and immune responses to pathogens. A recent meta-analysis indicated possible spatiotemporal clustering, though findings were hindered by data quality limitations. We investigated spatial clustering of using advanced methods complete residential histories. Methods included patients aged 0–17 years diagnosed in 1990–2019, Finnish Cancer Registry. 1:3 age- sex-matched...
Objectives Inhaled radon gas is a known alpha-emitting carcinogen linked especially to lung cancer. Studies on higher concentrations of indoor and childhood leukemia have conflicting but largely negative results. In this study, we aimed create sophisticated statistical model predict apply it Finnish case–control dataset. Methods Prediction was based ~80 000 measurements, which were national registries for potential predictors the literature. modelling, used classical methods, random forests...
The oncofetal protein insulin-like growth factor 2 mRNA-binding 3 (IGF2BP3) belongs to a family of RNA-binding proteins involved in localization, stability, and translational regulation target RNAs. IGF2BP3 is used as diagnostic prognostic marker several malignancies. Although the prognosis pediatric B-cell acute lymphoblastic leukemia (B-ALL) has improved, subgroup patients exhibits high-risk features suffer from disease recurrence. We sought identify additional biomarkers improve...
The present study aimed at investigating long-term mortality of patients who underwent solid organ transplantation during childhood and identifying their causes death.A cohort 233 pediatric transplant recipients had a kidney, liver, or heart between 1982 2015 in Finland were studied. Year birth-, sex-, hometown-matched controls (n = 1157) identified using the Population Register Center registry. Causes Death Registry was utilized to identify death.Among recipients, there 60 (25.8%) deaths...
Central nervous system (CNS) tumors are a leading cause of cancer-related morbidity and mortality in children. Our aim is to characterize incidence trends pediatric CNS Finland over the last three decades.Data on all benign malignant incident diagnosed children aged 0-14 years 1990-2017 were extracted from Finnish Cancer Registry classified according 2016 WHO classification tumors. We analyzed age-standardized rates (ASR) for overall by sex, age, tumor histology, grade, location using...
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy with no well-established prognostic biomarkers. We examined the expression of protein arginine methyltransferases across malignancies and discovered high levels PRMT7 mRNA in T-ALL, particularly mature subtypes T-ALL. The genetic deletion by CRISPR-Cas9 reduced colony formation T-ALL cells changed monomethylation patterns complexes associated RNA DNA processing pathogenesis. Among them was RUNX1, whose...
Abstract Background Childhood cancer survivors show a variety of late adverse effects on dental health. The purpose this study was to examine the prevalence and severity abnormalities in permanent dentition childhood leukemia survivors. Materials methods Retrospective analysis panoramic radiographs performed for 178 aged below 17 years at time diagnosis. Sex, age diagnosis, interval between ALL diagnosis follow‐up radiograph, treatment protocol, risk grouping were recorded. Abnormalities...
<title>Abstract</title> Objective This study explored how anticancer treatment affects the oral microbiome in pediatric patients and its link to mucositis (OM). It also examined effects of different mouth rinses (Caphosol vs. saline solution). Materials Methods Saliva samples were collected from before after chemotherapy a controlled, double-blind, randomized clinical trial. The trial compared Caphosol solution aged 2 17.99 years. Bacterial DNA saliva was analyzed using next-generation...
Abstract Acute lymphoblastic leukemia is marked by aberrant transcriptional features that alter cell differentiation, self-renewal, and proliferative features. We sought to identify the transcription factors exhibiting altered subtype-specific expression patterns in B-ALL report here SOX11, a developmental neuronal factor, aberrantly expressed ETV6-RUNX1 TCF3-PBX1 subtypes of acute B-cell leukemias. show high SOX11 leads alterations gene are typically associated with adhesion, migration,...
Abstract Background The prevalence of malignancies after pediatric solid organ transplantation was evaluated in a nationwide study. Methods All patients who had undergone kidney, liver, or heart during childhood between the years 1982 and 2015 Finland were identified. inclusion criteria age under 16 at over 18 last follow-up day. A total 233 (137 53 43 heart) transplant recipients enrolled. Controls ( n = 1157) matched by year birth, gender, hometown identified using Population Register...
Abstract Background Oral mucositis (OM) is a significant side effect of cancer treatment. The purpose this study was to compare topically administered Caphosol saline rinses in the prevention pediatric patients. Procedure A controlled, double‐blinded, and randomized clinical crossover recruited patients between 2 17.99 years age who were diagnosed with malignancy receiving either high‐dose methotrexate (≥1 g/m ), anthracycline, or cisplatin chemotherapy (NCT0280733). All received two 7‐day...
CT is an essential diagnostic tool in health care. However, delivers relatively high levels of radiation which has been associated with increased risk childhood cancer. To address this, we evaluated patterns and time trends use among children Finland during the period changes pediatric imaging practices were reported several countries.Data on CTs performed younger than 15 years obtained from Finland's largest eight hospitals. data included 1996-2010 estimated coverage more 80 % Finland....
T-cell acute lymphoblastic leukemia (T-ALL) is a hematological malignancy driven by abnormal activity of transcription factors. Here we report an aberrant expression the developmental factor SIX6 in TAL1-subtype T-ALL. Our results demonstrate that binding TAL1 and GATA3 factors into upstream enhancer element directly regulates expression. High was associated with inferior event-free survival within three independent patient cohorts. At functional level, CRISPR-Cas9-mediated knockout gene...
A lack of stored iron, indicated by low serum ferritin, has been associated with various clinical symptoms. There are no longitudinal data on the frequency ferritin measurements in children and adolescents.
The incidence of pediatric inflammatory bowel disease (PIBD) has increased dramatically during the past decades. This implies involvement environmental factors in etiology but lends no clues about specific agents. We evaluated clustering time and place residence at PIBD onset using a case-control setting with comprehensive nationwide register data.We included all cases diagnosed ages < 18 years 1992-2017 (3748 cases; median age 14.6; 2316 (58%) ulcerative colitis (UC), 1432 Crohn's, 18,740...
B-cell lineage acute lymphoblastic leukaemia (B-ALL) is the most common paediatric malignancy. Transcription factor lymphoma 6 (BCL6) essential to germinal centre formation and antibody affinity maturation plays a major role in mature malignancies. More recently, it was shown act as critical downstream regulator pre-BCR+ B-ALL. We investigated expression of BCL6 protein population-based cohort B-ALL cases detected moderate strong positivity through immunohistochemistry 7% (8/117); however,...