A5100401137- 3D Printing in Biomedical Research
- Cellular Mechanics and Interactions
- Nonlinear Dynamics and Pattern Formation
- Hydrogels: synthesis, properties, applications
- Lipid Membrane Structure and Behavior
- Bone Tissue Engineering Materials
- Energy Load and Power Forecasting
- Tissue Engineering and Regenerative Medicine
- S100 Proteins and Annexins
- Supramolecular Self-Assembly in Materials
- Solar Radiation and Photovoltaics
- Cellular transport and secretion
- RNA Interference and Gene Delivery
- Industrial Vision Systems and Defect Detection
- Petroleum Processing and Analysis
- Modular Robots and Swarm Intelligence
- Micro and Nano Robotics
- Wnt/β-catenin signaling in development and cancer
- Biotin and Related Studies
- Time Series Analysis and Forecasting
- Caveolin-1 and cellular processes
- Additive Manufacturing and 3D Printing Technologies
- Advanced Computational Techniques and Applications
- Ubiquitin and proteasome pathways
- Neuroscience and Neural Engineering
University of Hong Kong
2024-2025
Hohai University
2019-2024
Hangzhou City University
2024
Zhejiang University
2024
Chinese University of Hong Kong
2024
Nano and Advanced Materials Institute
2024
Nanjing Forestry University
2023
Huazhong University of Science and Technology
2017-2023
Wuhan Union Hospital
2023
First Affiliated Hospital of Xi'an Jiaotong University
2021
In situ bioprinting is promising for developing scaffolds directly on defect models in operating rooms, which provides a new strategy tissue regeneration. However, due to the limitation of existing biofabrication technologies including printing depth and suitable bioinks, deep dermal or extremity injuries remains grand challenge. Here, we present an vivo scaffold fabrication approach by minimally invasive electroactive hydrogel promote The system consists ferromagnetic soft catheter robot...
Hydrological time series is affected by many factors and it difficult to be forecasted accurately traditional forecast models. In this paper, a hydrological model based on wavelet de-noising ARIMA-LSTM proposed. The first removes the interference in de-noising, then uses ARIMA fit de-noised data obtain fitting residuals results. Then we use train LSTM network. Next, error of network used correct result model. daily average water level station Chuhe River Basin as experimental compare with...
Cells need to migrate through confined spaces during processes such as embryo development and cancer metastasis. However, the fundamental question of how confinement size surrounding rigidity collectively regulate migration capability cells remains unclear. Here, by utilizing maskless photolithography with a digital micromirror device (DMD), microchannel precisely controlled width wall stiffness (similar those exhibited natural tissues) is fabricated. We find that increasing confining leads...
A phenomenon of anti-degradation a recombinant complex protein (MPP6 protein) in small molecular hydrogel was reported this study.
The interactions between substrate materials and cells usually play an important role in the hydrogel-based 3D cell cultures. However, hydrogels that are used could not be parametrically regulated, especially for quantitatively regulating spatial distribution of adhesion sites 3D. Here, we employed semisynthetic hydrogel consisting maleimide-dextran, Arg-Gly-Asp (RGD) peptides, degradable crosslinkers to biochemically characterize evolutionary behaviors NIH-3T3 fibroblasts C2C12 Moreover, by...
Autonomous driving vehicle is a kind of unmanned on the ground. Navigation and positioning technology becoming an indispensable part practical applications, especially in intelligent transportation systems military fields. In this study, multi-source information fusion plays necessary role enhancing quality reliability navigation positioning. actual complex environment, accuracy requirements case nonlinear non-Gaussian distribution are fully considered. paper, new adaptive sharing factor...
Abstract Human mesenchymal stem cells (hMSCs) are one of the most promising candidates for cell-based therapeutic products. Nonetheless, their biomechanical phenotype after in vitro expansion is still unsatisfactory, example, restricting efficiency microcirculation delivered hMSCs further cell therapies. Here, we propose a scheme using maleimide-dextran hydrogel with locally varied stiffness microscale to modify properties three-dimensional (3D) niches. We show that spatial micro-variation...
Due to the structural and compositional similarity extracellular matrix (ECM), self-assembling peptide hydrogels (SAPHs) have shown potential as three-dimensional (3D) scaffolds in regenerative medicine. However, how fabricate SAPHs with controlled bioactivity for specific applications still remains greatly challenging. In this study, we develop a viable strategy prepare bioactive based on designed short amphiphilic peptides cell-adhesive motifs, through combination of enzymatic...
Abstract Stiffness of the extracellular matrix plays an important role in regulating cell migration. In this paper, two types 3D dextran hydrogel, with stiffness distributed homogeneously and heterogeneously subcellular scales, have been designed fabricated to serve as macromolecule scaffolds which C2C12 cells, immortalized mouse myoblast line, can migrate a rationally controllable manner. The experimental results indicate that heterogeneous gels support higher migration velocities,...
Biomaterials can serve as the cornerstone of extracellular matrices (ECMs) in three-dimensional (3D) cell culture. Designing diverse ECM materials with adjustable inner structures exhibits growing superiority inducing varied cellular behaviors, such spreading, proliferation, migration, differentiation, and apoptosis. However, a rational easy-to-implement strategy for regulating behaviors during self-organization 3D hydrogels is still lacking. In this study, we propose that...
The establishment of epithelial cell polarity requires the assembly multiprotein complexes and is crucial during morphogenesis. Three scaffolding proteins, Dlg1, MPP7, Mals3, can be assembled to form a complex that functions in maintenance apicobasal tissues through their L27 domains. Here we report crystal structure 4-L27-domain derived from human tripartite Dlg1-MPP7-Mals3 combination with paramagnetic relaxation enhancement measurements. heterotrimer consists 2 pairs heterodimeric These...
Aiming at the problem of fault-free scheduling in single process, a process dynamic algorithm is proposed by giving several principles and lemma. two-process, this paper puts forward definition determination principle "Balance Principle", "Rare CNC" "m-Center gives two-process based on these "single-process algorithm". with fault scheduling, number faulty workpieces determined according to 1% obtained corresponding algorithm, randomly assigned CNC time period failure, using finished working...
In order to optimize the wood internal quality detection and evaluation system improve comprehensive utilization rate of wood, this paper invented a set log defect visualization by using ultrasonic dry coupling agent method.The analysis defects were realized through specimen test.The main conclusions show that accuracy, reliability practicability for detecting specimens have been effectively verified.The can make edge detected image smooth interpolation algorithm, algorithm be used detect...
Cellular blebbing has been widely recognized as a hallmark of processes such apoptosis and cell migration. Here, we developed novel double-layer compression microfluidic device to trigger the enforced cells in programmable manner. It was found that critical for inducing membrane bleb highly invasive or drug-resistant breast lung cancer lines could be several times higher than their non-invasive drug-sensitive counterparts. Furthermore, showed knockdown annexin-6, protein known heavily...