A5020125353- Ubiquitin and proteasome pathways
- CAR-T cell therapy research
- Adipose Tissue and Metabolism
- Protein Degradation and Inhibitors
- Computational Drug Discovery Methods
- Mosquito-borne diseases and control
- CRISPR and Genetic Engineering
- Immunotherapy and Immune Responses
- Virus-based gene therapy research
- Receptor Mechanisms and Signaling
- Immune Cell Function and Interaction
- Monoclonal and Polyclonal Antibodies Research
- Pancreatic function and diabetes
- Diet and metabolism studies
- RNA modifications and cancer
- Mitochondrial Function and Pathology
- interferon and immune responses
- Histone Deacetylase Inhibitors Research
- Diabetes Treatment and Management
- Peptidase Inhibition and Analysis
- Viral Infections and Vectors
- Cancer, Hypoxia, and Metabolism
- RNA and protein synthesis mechanisms
- Diabetes and associated disorders
- Cytomegalovirus and herpesvirus research
Macmillan Cancer Support
2011-2014
The Nature Conservancy
2012-2013
Joslin Diabetes Center
2003-2012
Harvard University
2009-2012
Beth Israel Deaconess Medical Center
2003-2007
Karolinska Institutet
2006
University of Surrey
2003
Type 2 diabetes mellitus (DM) is characterized by insulin resistance and pancreatic β cell dysfunction. In high-risk subjects, the earliest detectable abnormality in skeletal muscle. Impaired insulin-mediated signaling, gene expression, glycogen synthesis, accumulation of intramyocellular triglycerides have all been linked with resistance, but no specific defect responsible for DM has identified humans. To identify genes potentially important pathogenesis DM, we analyzed expression muscle...
Peroxisome proliferator activator receptor-γ coactivator 1 (PGC-1) is a major candidate gene for diabetes-related metabolic phenotypes, contributing to decreased expression of nuclear-encoded mitochondrial genes in muscle and adipose tissue. We have demonstrated that PGC-1α -β reduced both genetic (Lepob/Lepob) acquired obesity (high fat diet). In C57BL6 mice, by 43% (p < 0.02) after week high diet persisted more than 11 weeks. contrast, reductions were not sustained obesity-resistant A/J...
The peroxisome proliferator-activated receptor γ coactivator-1 (PGC-1) family is a key regulator of mitochondrial function, and reduced mRNA expression may contribute to muscle lipid accumulation in obesity type 2 diabetes. To characterize the effects PGC-1 on metabolism, we overexpressed PGC-1α PGC-1β C2C12 myotubes using adenoviral vectors. Both -1β increased palmitate oxidation [31% (P<0.01) 26% (P<0.05) respectively] despite reductions cellular uptake [by 6% 21% (P<0.001)]. Moreover,...
The study was designed to evaluate whether changes in malonyl-CoA and the enzymes that govern its concentration occur human muscle as a result of physical training. Healthy, middle-aged subjects were studied before after 12-wk training program significantly increased VO2 max by 13% decreased intra-abdominal fat 17%. Significant decreases (25-30%) observed training, 24-36 h last bout exercise. They accompanied increases both activity (88%) mRNA (51%) decarboxylase (MCD) but no phosphorylation...