A5033763088- Advanced Neuroimaging Techniques and Applications
- RNA regulation and disease
- Transcranial Magnetic Stimulation Studies
- RNA Research and Splicing
- Advanced MRI Techniques and Applications
- Peripheral Nerve Disorders
- Reading and Literacy Development
- NMR spectroscopy and applications
- Multiple Sclerosis Research Studies
- Cognitive Science and Mapping
- Language Development and Disorders
- Single-cell and spatial transcriptomics
- Polyomavirus and related diseases
- Bone and Joint Diseases
- MRI in cancer diagnosis
- Functional Brain Connectivity Studies
- Muscle Physiology and Disorders
- Motor Control and Adaptation
- RNA modifications and cancer
- Neurobiology of Language and Bilingualism
- Bioinformatics and Genomic Networks
- Cancer-related molecular mechanisms research
- Genetic Neurodegenerative Diseases
- Cytomegalovirus and herpesvirus research
University of Genoa
2024-2025
University of Pisa
2021-2024
Fondazione Stella Maris
2021-2024
<h3>BACKGROUND AND PURPOSE:</h3> MS lesions exhibit varying degrees of axonal and myelin damage. A comprehensive description lesion phenotypes could contribute to an improved radiologic evaluation smoldering inflammation remyelination processes. This study aimed identify in vivo distinct types using quantitative susceptibility mapping mapping–weighted imaging characterize them through T1-relaxometry, mapping, diffusion MR imaging. The spatial distribution relation ventricular CSF was...
Background High-efficacy disease-modifying therapies (HETs) have substantially improved multiple sclerosis (MS) management, yet ongoing cognitive decline remains a concern. This study aims to assess Symbol Digit Modalities Test (SDMT) changes in patients with stable relapsing-remitting MS (RRMS) treated HETs and evaluate the role of baseline MRI biomarkers as predictors SDMT changes. Methods Consecutive RRMS underwent clinical, assessment at clinical re-evaluation after 24 months. Patients...
A quantitative biomarker for myelination, such as myelin water fraction (MWF), would boost the understanding of normative and pathological neurodevelopment, improving patients' diagnosis follow‐up. We quantified a rapidly relaxing pool identified MW using multicomponent three‐dimensional (3D) magnetic resonance fingerprinting (MRF) to evaluate white matter (WM) maturation in typically developing (TD) children alterations leukodystrophies (LDs). acquired DTI 3D MRF‐based R1, R2 MWF data 15 TD...
Introduction Cognitive difficulties and neuropsychological alterations in Duchenne Becker muscular dystrophy (DMD, BMD) boys are not yet sufficiently explored, although this topic could have a relevant impact, finding novel biomarkers of disease both at genetics neuroimaging point view. The current study aims to: 1) analyze the profile group DMD BMD without cognitive impairment with an assessment their executive functions; 2) explore structural connectivity DMD, BMD, age-matched controls...
Graph theory approach was used to analyze structural and functional connectivity networks identify candidate biomarkers of Mild Cognitive Impairment (MCI), a prodromal stage Alzheimer&rsquo;s disease (AD), for an early diagnosis intervention. We proposed method brain network analysis combine information. Through graph measures (Segregation, Centrality Global Efficiency), we evaluated the differences between MCI healthy control (HC) subjects as well possible effects physical/cognitive...
Motivation: Diffusion MRI (dMRI) is a very noisy technique. The low signal-to-noise ratio introduces uncertainties in diffusion metrics and structural connectivity measures. Goal(s): We searched for method to investigate the uncertainty dMRI measurements compare them across different magnetic field strengths. Approach: assessed using wild residual bootstrapping techniques group of 7 healthy subjects undergoing optimized acquisition protocols at 1.5T, 3T, 7T. Results: 7T are comparable with...
Motivation: Multicomponent Magnetic Resonance Fingerprinting (MRF) provides Myelin Water Fraction (MWF) maps in clinically-compatible scan time. However, it still requires validation and assessment of sensitivity robustness. Goal(s): We aimed to assess MWF stability model parameters variations, its spatial consistency healthy children, alterations leukodystrophies. Approach: Two-pool relaxation times exchange were varied a 10% range. profiles computed main WM tracts. was compared FA, R1, R2....
Abstract Sodium MRI can measure in vivo sodium concentrations people with multiple sclerosis, but the extent to which these alterations reflect metabolic dysfunction absence of tissue damage or neuroaxonal loss remains uncertain. Increases total concentration and extracellular are believed be indicative disruption space expansion. Conversely, increase intracellular may represent early transient responses neuronal insult, preceding overt damage. Here, we explored relationship between...
Childhood apraxia of speech (CAS) is a subtype motor disorder usually co-occurring with language impairment. A supramodal processing difficulty, involving executive functions (EFs), might contribute to the cognitive endophenotypes and behavioral manifestations. The present study aimed profile EFs in CAS, investigating relationship between EFs, severity, connectivity frontal aslant tract (FAT), white matter involved both EFs. total 30 preschool children CAS underwent speech, language, EF...
New biomarkers for myelination could improve the understanding of neurodevelopmental diseases and their diagnosis treatment. We quantified Myelin Water Fraction (MWF) using MRF in a cohort children with leukoencephalopathies age-matched controls we compared it to DTI-based FA. obtained normative curves white matter development both techniques. MWF discriminated between patients higher sensitivity than FA, was more myelin-specific independent degree axonal packing. Thanks short scan time...