A5081947189- Geology and Paleoclimatology Research
- Isotope Analysis in Ecology
- Marine Bivalve and Aquaculture Studies
- Ocean Acidification Effects and Responses
- Groundwater and Isotope Geochemistry
- Marine Biology and Ecology Research
- Methane Hydrates and Related Phenomena
- Paleontology and Stratigraphy of Fossils
- Immune Cell Function and Interaction
- Coral and Marine Ecosystems Studies
- Calcium Carbonate Crystallization and Inhibition
- Marine and coastal ecosystems
- Hydrocarbon exploration and reservoir analysis
- T-cell and B-cell Immunology
- Paleontology and Evolutionary Biology
- Geological and Geochemical Analysis
- Ichthyology and Marine Biology
- Marine and fisheries research
- Evolution and Paleontology Studies
- Karst Systems and Hydrogeology
- Marine animal studies overview
- Atmospheric and Environmental Gas Dynamics
- Astro and Planetary Science
- Microbial Community Ecology and Physiology
- Cytomegalovirus and herpesvirus research
University of California, Los Angeles
2016-2025
Center for Creative Leadership
2021-2024
Université de Bretagne Occidentale
2015-2024
University of Bristol
2023-2024
Office of Diversity and Inclusion
2023
Planetary Science Institute
2015-2023
Institute of the Environment
2020-2023
University of California System
2022-2023
Institut Universitaire Européen de la Mer
2015-2022
UCLA Health
2022
The carbon dioxide (CO2) content of the atmosphere has varied cyclically between approximately 180 and 280 parts per million by volume over past 800,000 years, closely coupled with temperature sea level. For earlier periods in Earth's history, partial pressure CO2 (pCO2) is much less certain, relation pCO2 climate remains poorly constrained. We use boron/calcium ratios foraminifera to estimate during major transitions 20 years. During Middle Miocene, when temperatures were 3 degrees 6 C...
Abstract Remains of megatheres have been known since the 18th -century and were among first megafaunal vertebrates to be studied. While several examples preserved integument show a thick coverage fur for smaller ground sloths living in cold climates such as Mylodon Nothrotheriops , comparatively very little is about megathere skin. Assuming typical placental mammal metabolism, it was previously hypothesized that would had little-to-no they achieved giant body sizes. Here “hairless model...
NKG2D (natural killer group 2, member D) binds to cellular ligands of the MIC and ULBP/RAET family. These have restricted expression in normal tissue, but are frequently expressed on primary tumors. The role is thought be important carcinogenesis its prognostic effect has not been investigated such a large cohort.In our study, 462 colorectal tumors were screened for all MIC/ULBP/RAET proteins NK cell infiltration. Tumor microarray technology was used purpose this investigation.NKG2D by...
The stable isotope compositions of biologically precipitated apatite in bone, teeth, and scales are widely used to obtain information on the diet, behavior, physiology extinct organisms reconstruct past climate. Here we report application a new type geochemical measurement bioapatite, “clumped-isotope” paleothermometer, based thermodynamically driven preference for 13 C 18 O bond with each other within carbonate ions bioapatite crystal lattice. This effect is dependent temperature but,...
Large dinosaurs had body temperatures similar to those of modern mammals and birds.
Abstract Background Cell surface NKG2D ligands (NKG2DL) bind to the activating receptor present on NK cells and subsets of T cells, thus playing a role in initiating an immune response. We examined tumor expression prognostic effect NKG2DL breast cancer patients. Methods Our study population (n = 677) consisted all patients primarily treated with surgery our center between 1985 1994. Formalin-fixed paraffin-embedded tissue was immunohistochemically stained antibodies directed against...
Abstract. The shells of marine mollusks are widely used archives past climate and ocean chemistry. Whilst the measurement mollusk δ18O to develop records change is a commonly approach, it has proven challenging reliable independent paleothermometers that can be deconvolve contributions temperature fluid composition on molluscan oxygen isotope compositions. Here we investigate dependence 13C–18O bond abundance, denoted by measured parameter Δ47, in shell carbonates bivalve assess its...
The evolution of mammalian olfaction is manifested in a remarkable diversity gene repertoires, neuroanatomy and skull morphology across living species. Olfactory receptor genes (ORGs), which initiate the conversion odorant molecules into odour perceptions help an animal resolve olfactory world, range number from mere handful to several thousand Within snout, each these ORGs exclusively expressed by discrete population sensory neurons (OSNs), suggesting that newly evolved may be coupled with...
Diet is a crucial trait of an animal's lifestyle and ecology. The trophic level organism indicates its functional position within ecosystem holds significance for ecology evolution. Here, we demonstrate the use zinc isotopes (δ66Zn) to geochemically assess in diverse extant extinct sharks, including Neogene megatooth shark (Otodus megalodon) great white (Carcharodon carcharias). We reveal that dietary δ66Zn signatures are preserved fossil tooth enameloid over deep geologic time robust...
Abstract We characterized two novel members of the RAET1/ULBP gene cluster, RAET1E and RAET1G. The encoded proteins were similar to ULBP in their class I-like α1 α2 domains, but differed that, instead being GPI-anchored, sequences type 1 membrane-spanning molecules. Both capable expressed at cell surface. bound activating receptor NKG2D, RAET1G human CMV protein UL16. expression diverse NKG2D-binding molecules different tissues with properties is consistent multiple modes infection- or...
To date five ULBP/RAET (UL16-binding protein, also known as retinoic acid early transcript) genes, encoded on human chromosome 6q24.2-q25.3, have been shown to encode ligands of the activating immunoreceptor NKG2D. Here, we show that a sixth gene, ULBP6/RAET1L, is polymorphic locus expresses functional transcript. ULBP6 had more restricted expression profile in cell lines and primary tissues than other NKG2D ligands, but was detected several papillomavirus-positive cervical carcinoma...
Benthic faunal communities have usually been described from data collected during a single survey, and it has assumed that most benthic are reasonably stable. However, in areas such as important fishing grounds or around effluent disposal where surveys repeated periodically, the results quite frequently show marked changes. These do not always correlate to annual breeding cycles but more unpredictable of different period.
Our understanding of the evolutionary transitions leading to modern endothermic state birds and mammals is incomplete, partly because tools available study thermophysiology extinct vertebrates are limited. Here we show that clumped isotope analysis eggshells can be used determine body temperatures females during periods ovulation. Late Cretaceous titanosaurid yield similar large endotherms. In contrast, oviraptorid lower than most endotherms but ∼ 6 °C higher co-occurring abiogenic...
The East Asian monsoon is one of Earth’s most significant climatic phenomena, and numerous paleoclimate archives have revealed that it exhibits variations on orbital suborbital time scales. Quantitative constraints the climate changes associated with these past are limited, yet needed to constrain sensitivity region in greenhouse gas levels. Here, we show central China a experienced much larger temperature change since Last Glacial Maximum than typically simulated by models. We applied...
Following the discovery of cell penetrant pyridine-4-carboxylate inhibitors KDM4 (JMJD2) and KDM5 (JARID1) families histone lysine demethylases (e.g., 1), further optimization led to identification non-carboxylate derived from pyrido[3,4-d]pyrimidin-4(3H)-one. A number exemplars such as compound 41 possess interesting activity profiles in KDM4C KDM5C biochemical target-specific, cellular mechanistic assays.
Thermal stress reduces pocilloporid coral resilience to ocean acidification by impairing control over calcifying fluid chemistry.
Trophic position is a fundamental characteristic of animals, yet it unknown in many extinct species. In this study, we ground-truth the 15N/14N ratio enameloid-bound organic matter (δ15NEB) as trophic level proxy by comparison to dentin collagen δ15N and apply method fossil record reconstruct megatooth sharks (genus Otodus). These evolved Cenozoic, culminating Otodus megalodon, shark with maximum body size more than 15 m, which went 3.5 million years ago. Very high δ15NEB values (22.9 ±...