A5064590573- COVID-19 Clinical Research Studies
- Hemoglobinopathies and Related Disorders
- SARS-CoV-2 and COVID-19 Research
- Infant Nutrition and Health
- Iron Metabolism and Disorders
- Diabetes and associated disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Child Nutrition and Water Access
- Tryptophan and brain disorders
- Liver Disease Diagnosis and Treatment
- Nutritional Studies and Diet
- Inflammatory Biomarkers in Disease Prognosis
- Stress Responses and Cortisol
- Diabetes, Cardiovascular Risks, and Lipoproteins
- HIV/AIDS Research and Interventions
- Tuberculosis Research and Epidemiology
- Diet and metabolism studies
- Pharmacological Effects and Toxicity Studies
- Heavy Metal Exposure and Toxicity
- Regulation of Appetite and Obesity
- Pregnancy and Medication Impact
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Vitamin C and Antioxidants Research
- Pesticide Exposure and Toxicity
- SARS-CoV-2 detection and testing
University of Ibadan
2014-2024
University College Hospital, Ibadan
2013-2023
Edo State University Uzairue
2017-2018
Background Substance use disorders (SUDs) continue to be a public health challenge of significant importance. The immunomodulatory effects substances abuse have been extensively studied but there is dearth information on their plasma interleukin-40 (IL-40) level, biomarker B cell activity, and its consequent total IgA level in patients with substance (SUD). Therefore, the levels IL-40 SUD were determined this study. Methods Ninety adults comprising 50 40 controls enrolled into case-control...
BackgroundThe prevalence of helminth infection, which is known to affect nutritional status the host, varies with age. The complex interplay between ages, nutrient requirements, and infection necessitated need recommend micronutrient supplementation during among different age groups.ObjectiveThe aim this study was determine pattern alteration in selected micronutrients pregnant women preschool- school-aged children infection.MethodsWe screened 245 349 for infection. Of these, 17 (6.9%) 102...
Abstract Background Clinical trial of IDO inhibitor or uses micro-nutrient supplements during management diseases is commonly done without having adequate basis for the practise. Tryptophan (Trp) an essential amino acid needed T-lymphocyte function, and indoleamine-2,3-dioxygenase (IDO) a potent immunoregulatory molecule that catalyses rate-limiting step Trp degradation in kynurenine (Kyn) pathway. Materials methods Human plasma samples was measured using ELISA patients with non-infectious...
Objective This study assessed the diagnostic performance and prognostic properties of C-reactive protein (CRP), copeptin cortisol in individuals with sickle cell anaemia (SCA). Design Prospective case-control Methods Sixty consecutive SCA subjects (18–40 years) comprising 30 steady state vaso-occlusive crisis (VOC) were recruited into this study. Thirty (30) apparently healthy HbAA genotype served as controls. ELISA was used for determination serum levels copeptin, CRP cortisol. Data...
Metabolic syndrome (MS) amplifies hypertension (HTN) associated with increased risk of cardiovascular disease (CVD). MS components and other CVD measures were investigated in different stages hypertension. 534 apparently healthy Nigerian traders aged 18–105 years participants a cohort study. The International Diabetes Federation (2005) the National High Blood Pressure Education Program Coordinating Committee criteria used for HTN classifications, respectively. Anthropometric indices obtained...
Welcome to Annals of Global Health,Annals Health is a peer-reviewed, fully open access, online journal dedicated publishing high quality articles all aspects global health. The journal's mission advance health, promote research, and foster the prevention treatment disease worldwide. Its goals are improve health well-being people, equity, wise stewardship earth's environment. latest impact factor 3.64.Annals supported by Program for Public Common Good at Boston College. It was founded in 1934...
Vitamin D deficiency (VDD) continues to be associated with schizophrenia, but there is the dearth of information on relationship between severity schizophrenia and plasma levels vitamin D. This study, therefore, determined in different groups schizophrenia.Plasma level was 60 patients 30 apparently healthy individuals who served as controls. Patients were classified into mildly ill, moderately markedly severely ill using Positive Negative Syndrome Scale (PANSS).The mean significantly lower...
To provide information on the usefulness of salivary immunoglobulin classes in diagnosis periodontitis.About 5 ml unstimulated saliva was collected from 25 newly diagnosed subjects with periodontitis and 21 sex/age-matched apparently healthy individuals into plain sample bottles. The samples were between 9 am 11 at least, 1 hour after eating or washing mouth levels (IgA, IgG, IgE IgM) determined using enzyme-linked immunosorbent assay (ELISA).Only mean level IgA significantly raised (p =...
Chronic inflammation and elevated basal metabolic rate (BMR) are established features of sickle-cell anemia (SCA). However, there is little information on the possible impacts these afore-mentioned glycemia insulin sensitivity status this group people.This study aims to determine as well effect BMR in adults with SCA steady state.Fifty participants comprising 30 state 20 age- gender-matched apparently healthy hemoglobin genotype AA (HbAA) that served controls. Anthropometric clinical indices...
ABSTRACT Aim: This study assessed the impact of dietary modification on cardiometabolic, inflammatory and oxidative stress indices in Nigerians with metabolic syndrome (MS). Subjects Methods: Sixty participants MS were selected using International Diabetes Federation criteria from a cohort participating “Risk Assessment Type 2 diabetes mellitus Dementia Metabolic Syndrome” study. The subjects seen by Dietitian approximate percentages total calories protein, fat, polyunsaturated carbohydrate...
Background: Mycobacterium tuberculosis and human immunodeficiency virus (HIV) are known to cause abnormal thyroid function. There is little information on whether HIV infection aggravates alteration of function in patients with MDRTB.Objectives: This study was carried out determine if co-infection alters serum levels hormones (T3, T4) stimulating hormone (TSH) MDR-TB find the frequency subclinical dysfunction before commencement therapy.Methods: observational cross-sectional involved all...
Background Reports on the evaluation of immune responses to different COVID-19 vaccines are limited. Similarly, effects age and gender have not been well explored as variables that could impact vaccine-induced antibody response. Therefore, seroprevalence anti-SARS-CoV-2 specific antibodies in vaccinated vaccine naïve adult Nigerians was determined this study. Methodology A total 141 adults were enrolled into Presence or absence SARS-CoV-2 infection confirmed by real-time...
Objective: Existence of crosstalk between metabolic and immune response against severe, acute respiratory syndrome coronavirus 2 (SARS-CoV-2) indicates that its full understanding could facilitate therapeutic insights for Coronavirus disease 2019 (COVID-19) management. Therefore, selected immunometabolic indices were determined in COVID-19 patients at a Nigerian Isolation Centre. Material Methods: Haematological parameters (Total White Blood Cell [TWBC] Differential Counts), inflammation...
Experimental studies have shown numerous health disorders associated with occupational exposure to organophosphate pesticides but evidence of impaired immune functions by in humans is scarce. This study determined complete blood count (CBC), serum immunoglobulin classes (IgE, IgA, IgM, IgG),acetylcholinesterase (AChE) activity and skin sensitivity prick test common environmental allergens 60 farm workers (30 pesticide applicators 30 farmers) exposed (OP) compared with30 apparently healthy,...
Background: As part of our contribution to the growing pool knowledge on prevention and control COVID-19 pandemic, this study describes demographic features patients with hospitalized at Infectious Disease Center (IDC), Olodo, Ibadan, Oyo State, Nigeria.Methodology: This was a descriptive cross-sectional whose data were collected during admission between April 27, 2020 June 20, 2020. SARS-CoV-2 infection diagnosed nasopharyngeal specimen using real-time reverse transcription–polymerase chain...
Objective: This study evaluated the effects of a 12-month dietary modification on indices inflammation and pro-thrombosis in adults with metabolic syndrome (MS).Materials methods: longitudinal involved 252 MS recruited from Bodija market, Ibadan its environs. Participants were placed 20%, 30% 50% calories obtained protein, total fat carbohydrate respectively followed up monthly for 12 months. Anthropometry blood pressure measured using standard methods. Fasting plasma glucose (FPG),...
Relationship between infections and human breast milk still requires more research especially, in developing countries. This study aims to evaluate the effects of HIV infection on immunologic factors plasma infected lactating mothers. Plasma concentrations immunoglobulins G, A, M E, caeruloplasmin (CLP), complement factor IIIc (C3c), α1-antitrypsin (A1AT), transferring (TRF) were determined 20 asymptomatic HIV-infected mothers (HIM) 30 age-matched HIV-free (seronegative) (HFM) using Enzyme...