Michael B. Papah

ORCID: 0000-0003-0306-7510
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About
Contact & Profiles
Research Areas
  • Animal Nutrition and Physiology
  • Fish Ecology and Management Studies
  • Meat and Animal Product Quality
  • Physiological and biochemical adaptations
  • Fish Biology and Ecology Studies
  • Genetic and phenotypic traits in livestock
  • Aquatic Ecosystems and Biodiversity
  • Identification and Quantification in Food
  • Muscle Physiology and Disorders
  • Molecular Biology Techniques and Applications
  • Bird parasitology and diseases
  • Aquaculture Nutrition and Growth
  • Demographic Trends and Gender Preferences
  • Ecology and biodiversity studies
  • Environmental and Biological Research in Conflict Zones
  • Nuclear Structure and Function
  • Water Quality Monitoring Technologies
  • Biotin and Related Studies
  • Aquatic Ecosystems and Phytoplankton Dynamics
  • Environmental Toxicology and Ecotoxicology
  • Reproductive biology and impacts on aquatic species
  • Trace Elements in Health
  • Fish biology, ecology, and behavior
  • RNA and protein synthesis mechanisms
  • Sperm and Testicular Function

University of Delaware
2017-2021

University of Agriculture in Krakow
2020

University of Arkansas at Fayetteville
2020

The Ohio State University
2020

United States Department of Agriculture
2020

University of Bologna
2020

University of Nairobi
2011-2019

Wooden Breast Disease (WBD), a myopathy that frequently affects modern broiler chickens, is disorder has been associated with significant economic losses in the poultry industry. To examine tissue changes onset and early pathogenesis of this disorder, time-series experiment was conducted using chickens from high-breast-muscle-yield, purebred commercial line. Birds were raised for up to seven weeks, subset birds sampled weekly. muscle tissues extracted at necropsy processed analysis by light...

10.1080/03079457.2017.1339346 article EN Avian Pathology 2017-06-13

Wooden Breast Disease (WBD), a myopathy in commercial broiler chickens characterized by abnormally firm consistency of the pectoral muscle, impacts poultry industry negatively due to severe reduction meat quality traits. To unravel molecular profile associated with onset and early development WBD chickens, we compared time-series gene expression profiles Pectoralis (P.) major muscles between unaffected affected birds from high-breast-muscle-yield, purebred line. P. biopsy samples were...

10.1371/journal.pone.0207346 article EN cc-by PLoS ONE 2018-12-05

Wooden breast disease (WBD) is a novel myopathy affecting the pectoralis major muscle of modern broiler chickens. The etiology WBD not currently known, but has been linked to increased feed efficiency, growth rate, and yield in Differential effect detected between regions p. sexes broilers—male birds cranial aspect tend be more severely affected by than females caudal aspect. This study aimed characterize biological differences birds. Samples were taken from aspects muscles 3-week-old,...

10.3389/fphys.2019.00764 article EN cc-by Frontiers in Physiology 2019-06-18

Previous transcriptomic studies have hypothesized the occurrence of slow myofiber-phenotype, and dysregulation lipid metabolism as being associated with development Wooden Breast (WB), a meat quality defect in commercial broiler chickens. To gain deep understanding manifestation implication these two biological processes health disease states chickens, cellular global expression specific genes related to respective were examined pectoralis major muscles modern fast-growing unselected...

10.1038/s41598-019-53728-8 article EN cc-by Scientific Reports 2019-11-20

Wooden breast is a muscle disorder affecting modern commercial broiler chickens that causes palpably firm pectoralis major and severe reduction in meat quality. Most studies have focused on advanced stages of wooden apparent at market age, resulting limited insights into the etiology early pathogenesis myopathy. Therefore, objective this study was to identify molecular signals transcriptional cascade by performing gene expression analysis two-week-old birds may later exhibit phenotype age 7...

10.3390/genes10100746 article EN Genes 2019-09-25

The small cichlid fish Alcolapia grahami lives in Lake Magadi, Kenya, one of the most extreme aquatic environments on Earth (pH ~10, carbonate alkalinity ~300 mequiv l(-1)). Magadi tilapia is only 100% ureotelic teleost; it normally excretes no ammonia. This interpreted as an evolutionary adaptation to overcome near impossibility sustaining NH3 diffusion gradient across gills against high external pH. In standard ammoniotelic teleosts, branchial ammonia excretion facilitated by Rh...

10.1242/jeb.078634 article EN Journal of Experimental Biology 2013-07-24

Several gene expression studies have been previously conducted to characterize molecular basis of Wooden Breast myopathy in commercial broiler chickens. These generally used a limited sample size and relied on binary disease outcome (unaffected or affected by Breast), which are appropriate for an initial investigation. However, identify biomarkers severity development, it is necessary use large number samples with varying degree severity. Therefore, this study, we assayed relatively (n = 96)...

10.1371/journal.pone.0243983 article EN cc-by PLoS ONE 2021-01-04

Observations of the Magadi tilapia Alcolapia grahami in hot, highly alkaline Lake revealed that they air breathe not only during hypoxia, as described previously, but also normoxia and hyperoxia. Air breathing under these latter conditions occurred within distinct groupings fish (pods) involved a small proportion population. properties (duration frequency) were quantified from video footage. population followed diel pattern with maximum extent pod formation occurring early afternoon. High...

10.1111/jfb.12289 article EN Journal of Fish Biology 2014-02-04

Abstract The Magadi tilapia, Alcolapia grahami , a small cichlid fish of Lake Magadi, Kenya lives in one the most challenging aquatic environments on earth, characterized by very high alkalinity, unusual water chemistry, and extreme O 2 ROS, temperature regimes. In contrast to fishes which live at temperatures substantially lower than 36–40 °C mammals birds, an isolated population (South West Hot Springs, SWHS) tilapia thrives fast-flowing hotsprings with daytime highs 43 night-time lows 32...

10.1038/srep26990 article EN cc-by Scientific Reports 2016-06-03

Wooden breast syndrome is a widespread and economically important myopathy vasculopathy of fast growing, commercial broiler chickens, primarily affecting birds with high feed efficiency large muscle yield. To investigate potential systemic physiological differences between affected unaffected by wooden breast, total 103 market-age Cobb 500 broilers were sampled for 13 blood parameters the relative weights pectoralis major muscle, minor external oblique wing, heart, lungs, liver, spleen....

10.3389/fphys.2020.00304 article EN cc-by Frontiers in Physiology 2020-04-07

Insect larvae are reported to be a major component of the simple but highly productive trophic web found in Lake Magadi (Kenya, Africa), which is considered one most extreme aquatic environments on Earth. Previous studies show that fish must display biochemical and physiological adjustments thrive under conditions lake. However, information for invertebrates lacking. In present study, occurrence larval chironomid Tanytarsus minutipalpus first time. Additionally, changes metabolism...

10.1242/bio.021139 article EN cc-by Biology Open 2016-01-01

Wooden breast is a muscle disorder affecting modern commercial broiler chickens that causes palpably firm pectoralis major and severe reduction in meat quality. Most studies have focused on advanced stages of wooden apparent at market age, resulting limited insights into the etiology early pathogenesis myopathy. Therefore, objective this study was to identify molecular signals transcriptional cascade by performing gene expression analysis two-week-old birds may later exhibit phenotype age 7...

10.20944/preprints201906.0194.v2 preprint EN 2019-08-18

Wooden breast is a muscle disorder affecting modern commercial broiler chickens that causes palpably firm pectoralis major and severe reduction in meat quality. Most studies have focused on advanced stages of wooden apparent at market age, resulting limited insights into the etiology early pathogenesis myopathy. Therefore, objective this study was to identify molecular signals transcriptional cascade by performing gene expression analysis two-week-old birds may later exhibit phenotype age 7...

10.20944/preprints201906.0194.v1 preprint EN 2019-06-20

Lake Magadi, Kenya, is one of the most extreme aquatic environments on Earth (pH~10, anoxic to hyperoxic, high temperatures). Recently, increased water demand and siltation have threatened viable hot springs near margins lake where Alcolapia grahami, only fish surviving in lake, live. These Magadi tilapia largely depend nitrogen-rich cyanobacteria for food are 100% ureotelic. Their exceptionally aerobic metabolic rate, together with their emaciated appearance, suggests that they...

10.1093/conphys/coz060 article EN cc-by Conservation Physiology 2019-01-01
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