A5031479526- Pain Management and Placebo Effect
- Pain Mechanisms and Treatments
- Pediatric Pain Management Techniques
- Infrared Thermography in Medicine
- Thermoregulation and physiological responses
- Empathy and Medical Education
- Botulinum Toxin and Related Neurological Disorders
- Psychosomatic Disorders and Their Treatments
- Optimism, Hope, and Well-being
- Psychological Treatments and Assessments
- Traumatic Brain Injury Research
- Neuropeptides and Animal Physiology
- Musculoskeletal pain and rehabilitation
- Heart Rate Variability and Autonomic Control
- Cancer, Stress, Anesthesia, and Immune Response
- Neuroscience of respiration and sleep
- Chemical Thermodynamics and Molecular Structure
- Acupuncture Treatment Research Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Veterinary Pharmacology and Anesthesia
- Chalcogenide Semiconductor Thin Films
- Semiconductor Quantum Structures and Devices
- Pain Management and Opioid Use
- Virtual Reality Applications and Impacts
- Traumatic Brain Injury and Neurovascular Disturbances
University of Maryland, Baltimore
2014-2025
National Center for Complementary and Integrative Health
2022-2023
Duke University
2023
National Institutes of Health
2022
The limited success in translating basic science findings into effective pain management therapies reflects, part, the difficulty reliably assessing experimental animals. This shortcoming is particularly acute field of chronic, ongoing pain. Quantitative analysis facial expressions-the grimace score-was introduced as a promising tool, however, it thought to assess only short or medium duration (minutes hours). Here, we test hypothesis that scores are reliable metric neuropathic pain, by...
Abstract Immersive virtual reality (VR) consists of immersion in artificial environments through the use real-time render technologies and latest generation devices. The users feel just as immersed they would an everyday life situation, this sense presence seems to have therapeutic potentials. However, VR mechanisms remain only partially known. This study is novel that, for first time research, appropriate controls contexts, immersive characteristics (ie, control VR), multifaceted objective...
<b><i>Introduction:</i></b> Many clinical trials fail because of placebo responses. Prior therapeutic experiences and patients’ expectations may affect the capacity to respond placebos in chronic disorders. <b><i>Objective:</i></b> The scope this study 763 orofacial pain healthy participants was compare magnitude prevalence effects determine putative role prior vs. expectations. <b><i>Methods:</i></b> We tested...
The parabrachial (PB) complex mediates both ascending nociceptive signaling and descending pain modulatory information in the affective/emotional pathway. We hypothesized that PB hyperactivity influences chronic behavior after trigeminal nerve injury rats. Following induction of neuropathic using constriction infraorbital (CCI-ION) model, rats displayed spontaneous markers mechanical hyperalgesia extending beyond receptive field injured nerve. neurons recorded from with CCI-ION amplified...
Clinical trials, laboratory experiments, and neuroimaging studies provide converging evidence that pain is highly sensitive to expectations, whether based on the psychosocial context surrounding treatment (e.g., placebo analgesia) or transient cues information about painful events pain-predictive cues). We asked analgesia modulate through same mechanisms dissociable brain pathways. Forty healthy volunteers rated in response noxious heat during functional magnetic resonance imaging (fMRI)...
Abstract No large-cohort studies that examine potential racial effects on placebo hypoalgesic exist. To fill this void, we studied in healthy and chronic pain participants self-identified as either African American/black (AA/black) or white. We enrolled 372 study participants, 186 with a diagnosis of temporomandibular disorder (TMD) race-, sex-, age-matched to participate experiment. Using well-established paradigm classical conditioning verbal suggestions, each individual sensitivity was...
Sex-related differences can influence outcomes of randomized clinical trials and may jeopardize the effectiveness pain management other therapeutics. Thus, it is essential to understand mechanistic translational aspects sex in placebo outcomes. Recently, studies healthy participants have shed light on how sex-related effects might outcomes, yet no research has been conducted a patient population. Herein, we used tripartite approach evaluate interaction prior therapeutic experience (eg,...
Blast-induced traumatic brain injury (blast-TBI) is associated with vestibulomotor dysfunction, persistent post-traumatic headaches and stress disorder, requiring extensive treatments reducing quality-of-life. Treatment prevention of these devastating outcomes require an understanding their underlying pathophysiology through studies that take advantage animal models. Here, we report cranium-directed blast-TBI in rats results signs pain last at least 8 weeks after injury. These occur without...
All treatments are given in a context, suggesting that conditioning cues may significantly influence therapeutic outcomes. We tested the hypothesis context affects placebo analgesia rodents. To produce neuropathic pain rats, we performed chronic constriction injury of infraorbital nerve. then treated rats daily, over seven day period, with injections either fentanyl or saline, without associated cues; fourth group received no treatment. On eighth day, replaced saline to test for conditioned...
Successfully predicting the susceptibility of individuals to placebo analgesics will aid in developing more effective pain medication and therapies, as well aiding potential future clinical use placebos. In pursuit this goal, we analyzed healthy chronic patients' patterns responsiveness during conditioning rounds their links conditioned analgesia mediating effect expectation on those responses. We recruited 579 participants (380 healthy, 199 with temporomandibular disorder (TMD)) participate...
ABSTRACT Introduction The COVID-19 pandemic has been shown to have profound effects on both mental and physical health. Distress widespread uncertainty about global events personal risk are associated with increased worry negative expectations that impact Thus, the current poses a possibility for experience of nocebo effects. Objective To evaluate likelihood nocebo-induced symptoms in US sample. Methods An online study health asked participants complete set biweekly surveys over 6-month...
Introduction: Quantitative Sensory Testing (QST) allows researchers and clinicians to evaluate variations in acute pain thermosensation within across individuals. With a variety of QST approaches available, it is important whether the modality used for induction affects conclusions drawn from QST. We compared two types thermodes (an Advanced Thermal Stimulator (ATS) Contact Heat-Evoked Potential (CHEPS)) at stimulus durations (8s 3s, respectively) assess potential differences...