A5063397645- Brucella: diagnosis, epidemiology, treatment
- Escherichia coli research studies
- Burkholderia infections and melioidosis
- Galectins and Cancer Biology
- Viral gastroenteritis research and epidemiology
- Infant Nutrition and Health
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Bacteriophages and microbial interactions
University of Concepción
2020-2024
Brucella abortus is a facultative intracellular pathogen that causes zoonosis called brucellosis. This disease leads to abortion and infertility in cattle, diverse complications humans. B. successful bacterium has developed the ability evade host's immune system it replicates professional non-professional phagocytic cells, persisting different tissues organs of its hosts. It been described expresses polar flagellum under certain conditions, but function still unknown. In this study we...
Shiga toxin-producing Escherichia coli (STEC) causes outbreaks and sporadic cases of gastroenteritis. STEC O157:H7 is the most clinically relevant serotype in world. The major virulence determinants are toxins locus enterocyte effacement. However, several accessory factors, mainly outer membrane proteins (OMPs) that interact with host cells may contribute to this pathogen. Previously, elongation factor thermo unstable (EF-Tu), l-asparaginase II OmpT were identified as antigens OMP extracts...
Toxin/antitoxin (TA) systems have been scarcely studied in Brucella abortus, the causative agent of brucellosis, which is one most prevalent zoonotic diseases worldwide. In this study, roles a putative type II TA system composed by Zinc-dependent metalloproteinase (ZnMP) and transcriptional regulator HTH-Xre were evaluated. The deletion open reading frame (ORF) BAB1_0270, coding for ZnMP, used to produce mutant strain, allowed us evaluate survival gene expression B. abortus 2308 under...
Introduction The lncRNAs (long non-coding RNAs) are the most diverse group of RNAs and involved in biological processes including immune response. While some them have been recognized for their influence on regulation inflammatory activity, little is known context infection by Brucella abortus , a pathogen that presents significant challenges due to its ability manipulate evade host system. This study focuses characterize expression profile LincRNA-cox2, Lethe, lincRNA-EPS, Malat1 Gas5...