A5063634967- Air Quality and Health Impacts
- Smoking Behavior and Cessation
- Indoor Air Quality and Microbial Exposure
- Carcinogens and Genotoxicity Assessment
- Noise Effects and Management
- Toxic Organic Pollutants Impact
- Air Quality Monitoring and Forecasting
- Heavy Metal Exposure and Toxicity
- Pesticide Exposure and Toxicity
- Nonmelanoma Skin Cancer Studies
- Signaling Pathways in Disease
- Environmental Justice and Health Disparities
- Cardiac Ischemia and Reperfusion
- Gut microbiota and health
- Cell death mechanisms and regulation
- Contact Dermatitis and Allergies
- Risk Perception and Management
- International Human Rights and Reproductive Law
- Vehicle emissions and performance
- Behavioral Health and Interventions
- Skin Protection and Aging
- Ion channel regulation and function
- Burn Injury Management and Outcomes
- Pesticide Residue Analysis and Safety
- Immunotoxicology and immune responses
San Diego State University
2016-2025
Graduate School USA
2018
University of California, Irvine
2004
National Cancer Institute
1995-1996
California Department of Toxic Substances Control
1996
University of Colorado Health
1996
Chinese Preventive Medicine Association
1996
Shanghai Municipal Center For Disease Control Prevention
1996
National Institutes of Health
1996
University of California, Berkeley
1996
In the present study, it was shown that physiologically relevant levels of proinflammatory cytokine TNFalpha induced apoptosis in rat cardiomyocytes vitro, as quantified by single cell microgel electrophoresis nuclei ("cardiac comets") well morphological and biochemical criteria. It also stimulated production endogenous second messenger, sphingosine, suggesting sphingolipid involvement TNFalpha-mediated cardiomyocyte apoptosis. Consistent with this hypothesis, sphingosine strongly The...
Exposure to particulate matter (PM) air pollution has been shown exacerbate children's asthma, but the exposure sources and temporal characteristics are still under study. Children's PM is likely involve both combustion-related ambient related a child's activity in various indoor outdoor microenvironments. Among 19 children with 9-17 years of age, we examined relationship changes percent predicted forced expiratory volume 1 sec (FEV1) personal continuous 24-hr average gravimetric mass...
Background This study examined whether thirdhand smoke (THS) persists in smokers' homes after they move out and non-smokers in, new non-smoking residents are exposed to THS these homes. Methods The of 100 smokers 50 were visited before the moved out. Dust, surfaces, air participants' fingers measured for nicotine children's urine samples analysed cotinine. who into recruited if non-smokers. residents' 25 former smoker 16 non-smoker A sample was collected from youngest resident. Results...
<h3>Background</h3> Over a 6-month period, we examined tobacco smoke pollutants (also known as thirdhand smoke, THS) that remained in the homes of former smokers and exposure to these pollutants. <h3>Methods</h3> 90 completed study measures at baseline (BL). Measures were repeated among verified quitters 1 week (W1), month (M1), 3 months (M3) 6 (M6) following cessation. analysed for THS on household surfaces, fingers dust (ie, nicotine, tobacco-specific nitrosamines) urinary markers...
<h3>Introduction</h3> This study examined tobacco smoke pollution (also known as thirdhand smoke, THS) in hotels with and without complete smoking bans investigated whether non-smoking guests staying overnight these were exposed to pollutants. <h3>Methods</h3> A stratified random sample of (n=10) (n=30) was examined. Surfaces air analysed for pollutants (ie, nicotine 3-ethynylpyridine, 3EP). Non-smoking confederates who stayed guestrooms provided urine finger wipe samples determine exposure...
In this nested case-control study we examined the relationship between non-Hodgkin's lymphoma (NHL) and organochlorine pesticide exposure. We used a data set originally collected 1969 1983 in U.S. Environmental Protection Agency National Human Adipose Tissue Survey. samples were randomly from cadavers surgical patients, levels of residues determined. From original population, 175 NHL cases identified matched to 481 controls; 173 controls selected accident victims, 308 with diagnosis...
Regular tobacco use in the enclosed environment of a car raises concerns about longer-term contamination car's microenvironment with residual secondhand smoke pollutants. This study (a) developed and compared methods to measure cars smoke, (b) examined whether smokers nonsmokers were contaminated by (c) how smoking behavior restrictions affected levels. Surface wipe, dust, air samples collected used sold (n=20) (n=87) analyzed for nicotine. Sellers interviewed restrictions, interiors...
Tobacco-specific nitrosamines (TSNAs) are emitted during smoking and form indoors by nitrosation of nicotine. Two them,
Occupational exposure to benzene is known cause leukemia, but the mechanism remains unclear. Unlike most other carcinogens, and its metabolites are weakly or nonmutagenic in simple gene mutation assays. Benzene do, however, produce chromosomal damage a variety of systems. Here, we have used glycophorin A (GPA) loss assay evaluate nature DNA produced by 24 workers heavily exposed 23 matched control individuals Shanghai, China. The GPA identifies stem cell precursor erythroid mutations...
Abstract Introduction Simple silicone wristbands (WB) hold promise for exposure assessment in children. We previously reported strong correlations between nicotine WB worn by children and urinary cotinine (UC). Here, we investigated differences chemical concentrations among exposed to secondhand smoke from conventional cigarettes (CC) or vapor electronic (EC), living with nonusers of either product (NS). Methods Children (n = 53) wore three a passive air sampler 7 days one 2 days, gave urine...
Benzene is a recognized hematotoxin and leukemogen, but its mechanisms of action in humans are still uncertain. To provide insight into these processes, we carried out cross-sectional study 44 healthy workers currently exposed to benzene (median 8-hr time-weighted average; 31 ppm), unexposed controls Shanghai, China. Here an overview the results on peripheral blood cells levels somatic cell mutation frequency measured by glycophorin A (GPA) gene loss assay report cytokine levels. All (i.e.,...
Secondhand smoke (SHS) in US casinos is common, but little known about the residue of tobacco pollutants left behind dust and on surfaces, commonly referred to as thirdhand (THS). We examined SHS THS pollution exposure before during a casino smoking ban after resumed.A was visited nine times over 15-month period collect dust, surface air samples eight locations. Finger wipe urine were collected from non-smoking confederates 4-hour visit. Samples analysed for markers exposure.Exceptionally...
Background: Thirdhand smoke (THS) pollutants, such as nicotine, accumulate on the hands of children who live in homes with smokers and are exposed to secondhand smoke. Our objective was examine whether levels hand nicotine associated demographics, environmental factors, clinical findings. Methods: Participants were caregivers (mean age (SD) = 2.6 (3.7) years) part an ongoing 2-group, randomized controlled trial emergency department–based tobacco cessation intervention (N 104). The primary...
Starting in the 1970s, individuals, businesses and public have increasingly benefited from policies prohibiting smoking indoors, saving thousands of lives billions dollars healthcare expenditures. Smokefree to protect against secondhand smoke exposure, however, do not fully persistent toxic chemical residues tobacco (also known as thirdhand smoke) that linger indoor environments for years after stops. Nor these address economic costs bear their attempts remediate this residue. We discuss...
<h3>Introduction</h3> Some car rental companies in California and other states the USA have established non-smoking policies for their vehicles. This study examined effectiveness of these maintaining smoke-free cars. <h3>Methods</h3> A stratified random sample 250 cars (non-smoker, smoker unknown designation) was San Diego County, California, USA. Dust, surfaces air each vehicle cabin were sampled analysed residual tobacco smoke pollutants (also known as thirdhand (THS)), inspected visual...
Toxic tobacco smoke residue, also known as thirdhand (THS), can persist in indoor environments long after has been smoked. This study examined the effects of different cleaning methods on nicotine dust and surfaces.