A5072572624- Histone Deacetylase Inhibitors Research
- Immune Cell Function and Interaction
- interferon and immune responses
- Alzheimer's disease research and treatments
- Technology Adoption and User Behaviour
- Advanced Glycation End Products research
- Cholinesterase and Neurodegenerative Diseases
- Barrier Structure and Function Studies
- Customer Service Quality and Loyalty
- Entrepreneurship Studies and Influences
- Mitochondrial Function and Pathology
- RNA Research and Splicing
- Adipose Tissue and Metabolism
- Noise Effects and Management
- Coding theory and cryptography
- Anesthesia and Neurotoxicity Research
- Protease and Inhibitor Mechanisms
- Knowledge Management and Sharing
- GABA and Rice Research
- Oral and gingival health research
- Menopause: Health Impacts and Treatments
- PARP inhibition in cancer therapy
- Digital Marketing and Social Media
- Protein Kinase Regulation and GTPase Signaling
- Cryptography and Data Security
National Agri-Food Biotechnology Institute
2019-2025
Mata Chanan Devi Hospital
2024
Panjab University
2012-2022
University of Saskatchewan
2021-2022
BLK Super Speciality Hospital
2018
Ansal University
2017
Guru Gobind Singh Indraprastha University
2017
IMS Unison University
2017
Upon binding double-stranded DNA (dsDNA), cyclic GMP-AMP synthase (cGAS) is activated and initiates the cGAS-stimulator of IFN genes (STING)-type I interferon pathway. DEAD-box helicase 41 (DDX41) a helicase, mutations in DDX41 cause myelodysplastic syndromes (MDSs) acute myeloid leukemia (AML). Here, we show that DDX41-knockout (KO) cells have reduced type production after virus infection. Unexpectedly, activations cGAS STING are affected KO cells, suggesting functions upstream cGAS. The...
Hyperglycemia is known to induce microvascular complications, thereby altering blood-brain barrier (BBB) permeability. This study investigated the role of matrix metalloproteinases (MMPs) and their endogenous inhibitors in increased BBB permeability evaluated protective effect S-nitrosoglutathione (GSNO) diabetes. Diabetes was induced mice by intraperitoneal injection streptozotocin (40 mg/kg body weight) for 5 days GSNO administered orally (100 μg/kg daily 8 weeks after induction A...
Abstract Aims Over the past few decades, overweight and obesity have become a significant health concern globally. There are several contributing factors for development, however energy-rich diets sedentary lifestyles major factors. Diet-based interventions play part in curing obesity. In this study, impact of putative probiotic bacterial blend (BB), isomaltooligosaccharides (IMOs), their combination as synbiotic (SB) was investigated on alleviation metabolic derangements, gut dysbiosis,...
The purpose of this paper is to explicate a comprehensive model explaining the impact perceived security on consumer purchase intentions and how it contributes trust satisfaction towards an e-retailer in online shopping context.Through extensive literate review, was found that two attributes website personality, i.e., transaction payment system are constituents security.Thus, study attempted explore relationships between security, trust, intentions.The additionally provides valuable...
DDX43 (DEAD-box helicase 43), also known as HAGE (helicase antigen gene), is a member of the DEAD-box protein family. It contains K homology (KH) domain in its N terminus, core C and flexible linker between. expression low or undetectable normal tissue, but overexpressed many tumors; therefore, it considered potential target molecule for cancer therapy. We, along with other groups, have shown that an ATP-dependent RNA DNA helicase, KH required ATPase unwinding activity. Electrophoretic...
Mitochondrial dysfunctions have been implicated in the progression of Huntington's disease (HD). To date, several free radical scavengers tested experimental HD, but only a few shown promise. Although most antioxidants rapidly reduce ROS process they are oxidized, which limits their ability to protect. Therefore, present study we employed potent recycling antioxidant, 4-hydroxy tempo (4-HT), because it can reinstate its reduced state even after oxidation during scavenging ROS. Female Wistar...
Transformation of committed 3T3-L1 preadipocytes to lipid-laden adipocytes involves the timely appearance numerous transcription factors (TFs); foremost among them, C/EBPβ is expressed during early phases differentiation. Here, we describe liposome-mediated protein transfection approach rapidly downregulate by A-C/EBP inhibitor. Signals from EGFP-tagged were observed in cells within 2 h transfections, whereas for gene equivalent signals appeared 48 h. Following transient expression profiles...
Abstract Epigenetic mechanisms related to diabetes-afflicted CNS complications are largely unknown. The present study investigated the role of epigenetic causing cognitive dysfunction in Type 1 and 2 diabetic encephalopathy mice model. Dynamic changes parameters like fasting blood glucose levels, tolerance tests, insulin levels were observed after induction diabetes. Cognitive functions significantly diminished T1D T2D examined by Morris water maze, novel object recognition test, Y Maze....
Human papillomavirus (HPV) has been linked as a potential risk factor for increasing incidence of oropharyngeal carcinoma. The present study aimed to evaluate the role clinicopathologic factors in outcome prediction subjects having carcinoma associated with HPV and managed surgery. retrospective assessed data from 54 that were diagnosed stage III or IV HPV-associated surgery without adjuvant therapy. mean follow-up duration was 2.7 years. recurrence-free survival overall rates [age, number...
The paper aims to elucidate a comprehensive model explaining the parallel mediation effect of consumer trust and satisfaction between web interface features purchase intentions how does it make contribution towards e-retailers in shopping setting. With help an depth literature analysis we discovered eight features, i.e., site design, convenience, transaction security, payment system, customer communication, delivery information, product information special content information. Thus attempted...
Abstract Transformation of committed 3T3-L1 preadipocytes to lipid-laden adipocytes involves timely appearance numerous transcription factors (TFs), foremost among them C/EBPβ, is expressed during early phases differentiation. Here we describe liposome-mediated protein transfection approach rapidly downregulate C/EBPβ by A-C/EBP inhibitor. Signals from tagged were observed in cells within 2hrs inhibitor transfections whereas for gene signals appeared 48hrs. Following transient transfections,...
The purpose of this study is to explicate the preferences Indian consumers towards attributes online shopping websites. Through an in depth literature review, we discovered three website considered as most important by that will increase their purchase intensions i.e. perceived usability, security and information quality. These consists eight different factors namely site design, convenience, transaction security, payment system, delivery, product value, customer communication special...