A5006509425- Multiple Myeloma Research and Treatments
- Cancer Treatment and Pharmacology
- Peptidase Inhibition and Analysis
- Medicinal Plant Pharmacodynamics Research
- Pain Mechanisms and Treatments
- Cancer Mechanisms and Therapy
- Protein Degradation and Inhibitors
- Bone health and osteoporosis research
- Glycosylation and Glycoproteins Research
- Cancer therapeutics and mechanisms
- Plant Reproductive Biology
- Plant Molecular Biology Research
- Hematological disorders and diagnostics
- Circular RNAs in diseases
- Optical Wireless Communication Technologies
- Photosynthetic Processes and Mechanisms
- Bone Metabolism and Diseases
- Pharmacological Effects of Natural Compounds
- Galectins and Cancer Biology
- Oral health in cancer treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Plant Stress Responses and Tolerance
- Ginseng Biological Effects and Applications
- Neonatal Respiratory Health Research
- Hepatocellular Carcinoma Treatment and Prognosis
Shanghai Zhabei District Shibei Hospital
2010-2025
Nanjing Agricultural University
2021-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2006-2024
Kunming Medical University
2024
IRD Fuel Cells (Denmark)
2024
Shaanxi Normal University
2024
Shanghai Jiao Tong University
2020-2023
North China University of Science and Technology
2020
North China University of Science and Technology Affiliated Hospital
2020
Hebei North University
2019
This study aimed to explore the heterogeneity of circRNA expression pattern via microarray, and further evaluate potential 10 specific circRNAs as diagnostic prognostic biomarkers in multiple myeloma (MM).In exploration stage (stage I), profiles were detected by microarray bone marrow plasma cells from 4 MM patients healthy controls (HCs), bioinformatic analyses performed. In validation II), top upregulated downregulated identified I 60 30 HCs for validation; values these analyzed.In I, 122...
Abstract To overcome pathogen infection, plants deploy a highly efficient innate immune system, which often uses hydrogen peroxide (H2O2), versatile reactive oxygen species, to activate downstream defense responses. H2O2 is potential substrate of aquaporins (AQPs), the membrane channels that facilitate transport small compounds across plasma membranes or organelle membranes. date, however, functional relationship between AQPs and in plant immunity largely undissected. Here, we report rice...
Diabetic peripheral neuropathy (DPN) is mainly characterized by demyelination resulted from the apoptosis of Schwann cell (SCs). Although exact mechanisms underlying DPN remain unclear, endoplasmic reticulum (ER) stress strongly implicated in apoptosis. Under ER stress, activated inositol-requiring kinase 1α (IRE1α) unregulated CHOP, phosphorylated JNK and Caspase-12 to aggravate apoptosis-mediated damage DPN. Therefore, we tested hypothesis that inhibition IRE1α could reduce stress-related...
Asthma is characterized by chronic airway inflammation, leading to structura1 changes in the airway, collectively termed remodeling. Airway remodeling thought contribute hyper responsiveness and irreversible airflow limitation. The combination of Herba Epimedii (HE) Fructus Ligustri Lucidi (FLL) decoction systemic administration glucocorticoids (GC) had a synergistic inhibitory action on inflammation asthmatic model rats. However, effects have not been studied compared. In present study, we...
The highly variable and species-specific pollen surface patterns are formed by sporopollenin accumulation. template for deposition polymerization is the primexine that appears on tetrad surface, but mechanism(s) which guides exine patterning remain elusive. Here, we report Poaceae-specific EXINE PATTERN DESIGNER 1 (EPAD1), encodes a nonspecific lipid transfer protein, required integrity in rice (Oryza sativa). Disruption of EPAD1 leads to abnormal pattern complete male sterility, although...
The decoction combination of Herba Epimedii and Fructus Ligustri Lucidi has been used to treat osteoporosis for almost 50 years by practitioners traditional Chinese medicine. However, it is unclear what specific effects this herbs on the skeleton. aim study was assess combined extracts from bone turnover mineral content in a rat model induced retinoic acid. Fifty male Wistar rats were randomly assigned normal control group, or treatment groups which then administered at 50, 100, 200...
Abstract Coronary artery disease (CAD) causes myocardial ischemia, narrowing or occlusion of the lumen. Although great progress has been made in treatment CAD, existing methods do not meet clinical needs, so it is urgent to find new methods. The aim this study was investigate mechanism action miR‐148a‐3p alleviating CAD by inhibiting vascular endothelial cell injury and provide ideas for CAD. A model constructed lipopolysaccharide (LPS) induction cells, a rat established high‐fat diet...
Objective Thrombotic events (TEs) are common and severe complications of newly diagnosed multiple myeloma (NDMM). However, the impact thrombosis on survival patients remains controversial. The aim our study was to identify independent high-risk factors for as well explore association between incidence TEs in with NDMM.
The ability to efficiently screen plant pathogen effectors is crucial for understanding plant-pathogen interactions and developing disease-resistant crops. Traditional methods are often labor-intensive time-consuming. Here, we present a robust, high-throughput screening assay using the tobacco mosaic virus-green fluorescent protein (TMV-GFP) vector system. system combines TMV-GFP Agrobacterium-mediated transient expression in model Nicotiana benthamiana. This enables rapid identification of...
Abstract In Arabidopsis thaliana, female gametophyte (FG) development is accompanied by the formation and expansion of large vacuole in FG; this essential for FG expansion, nuclear polar localization, cell fate determination. VACUOLELESS GAMETOPHYTES (VLG) facilitates vesicular fusion to form FG, but regulation VLG remains largely unknown. Here, we found that gain-of-function mutation BRASSINOSTEROID INSENSITIVE2 (BIN2) (bin2-1) increases abundance induce at stage FG1, leads abortion FG....
The combination of Herba Epimedii and Fructus Ligustri Lucidi has been used to treat osteoporosis for almost 50 years by Professor Shizeng Li, a famous doctor traditional Chinese medicine (TCM). However, it is unclear whether the effective constituents two herbs may have protective influence on skeleton. In present study, we investigated effects extracts rat model induced retinoic acid gavage. With administrations (50, 100, 200 mg/kg/day) via oral gavage 3 weeks, bone mineral density (BMD),...
Our previous study observed that circular RNA protein tyrosine kinase 2 (circ-PTK2) was upregulated and correlated with worse clinical features unfavorable prognosis in multiple myeloma (MM) patients. Thus, this aimed to further characterize the regulatory function of circ-PTK2 on cell malignant activities its target microRNA-638 (miR-638) as well downstream MEK/ERK, WNT/β-catenin signaling pathways MM. The effect MM proliferation, apoptosis, migration, invasion potential miRNAs assessed by...
The Second Revision of the International Staging System (R2-ISS) was recently introduced to improve risk stratification over that provided by extensively applied standard revised (R-ISS). In addition variables included in R-ISS, R2-ISS incorporates chromosome 1q gain/amplification and divides patients into 4 groups with different survival outcomes, better stratifying within R-ISS intermediate-risk. new model developed based on a great quantity data from participating uniform clinical trials...
Objective: To analyze the clinical characteristics of IgG4-related disease (IgG4-RD)so as to improve understanding IgG4-RD in China. Methods: patients were recruited from Peking Union Medical College Hospital between January 2011 and 2016. All followed-up for more than 6 months. The demographic characteristics, symptoms, organ involvements, laboratory examinations treatment efficacy evaluated analyzed. Results: A total 346 finally enrolled, including 230 males (66.5%) 116 females (33.5%)....
Gain or amplification 1q21 (1q21+) is one of the most common recurrent cytogenetic abnormalities in multiple myeloma (MM). Our aim was to explore presentation and outcomes patients with MM harboring + .We retrospectively analyzed clinical features survival 474 consecutive receiving immunomodulatory drugs proteasome inhibitor-based regimens as first-line therapies.1q21 detected 249 (52.5%) patients. Patients had a higher proportion subtypes IgA, IgD, λ-light chain than non-1q21 . associated...
Patients with relapsed/refractory (R/R) multiple myeloma (MM) complicated by severe heart failure typically do not tolerate conventional chemotherapy. Our previous study indicated that R/R MM patients comorbidities could benefit from continuous low-dose oral cyclophosphamide and prednisone (CP regimen). We hereby performed a of 56 (New York Heart Association class ≥ III) receiving the treatment CP regimen. Among 54 evaluable patients, clinical was noted in 63.0% (complete response, 3.7%;...
We report here the identification of four Mamu-A1 and Mamu-B novel alleles Chinese-origin rhesus macaques.
Background/objective We retrospectively analyzed the effective and safety of continuous low-dose cyclophosphamide combined with prednisone (CP) in relapsed refractory multiple myeloma (RRMM) patients severe complications. Methods A total 130 RRMM complications were enrolled this study, among which 41 further given bortezomib, lenalidomide, thalidomide or ixazomib on basis CP regimen (CP+X group). The response to therapy, adverse events (AEs), overall survival (OS) progression-free (PFS)...
Abstract. A type II membrane protein similar to CD69 (TIIMPSC) has been isolated in human embryo fibroblasts treated with IFN‐α. Structural analysis and immunofluorescence detection suggested that this is located on the surface of fibroblasts, generally considered, a receptor. Cell proliferation assay revealed activation TIIMPSC elevates level fibroblast proliferation. Further, examination signal transduction indicated expression up‐regulated by IFN‐α stimulation, it involved regulation...
This study investigates the effect of standardized management cancer pain on patients with bone metastasis lung in China.A total 123 were selected from Respiratory Department Affiliated Hospital North China University Science and Technology. Among these patients, 62 who had not received March 12, 2018, to September 11, as control group. In contrast, 61 2019, observation The former cohort accepted conventional pain, while latter strict, pain. demographic statistics, disease characteristics,...