A5108056065- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Research Studies
- Cancer Genomics and Diagnostics
- Esophageal Cancer Research and Treatment
- Cancer Mechanisms and Therapy
- Advanced X-ray and CT Imaging
- Peptidase Inhibition and Analysis
- Nutrition and Health in Aging
- Cancer, Hypoxia, and Metabolism
- Advanced Radiotherapy Techniques
- Colorectal Cancer Treatments and Studies
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Cancer Research and Treatments
- Prostate Cancer Treatment and Research
- Neuroendocrine Tumor Research Advances
- Gastric Cancer Management and Outcomes
- Effects of Radiation Exposure
- Tannin, Tannase and Anticancer Activities
- Synthesis and biological activity
- Andrographolide Research and Applications
- Autoimmune Bullous Skin Diseases
- Garlic and Onion Studies
Hangzhou Cancer Hospital
2016-2025
Zhejiang University
2019-2025
Hunan Normal University
2024-2025
Jiangxi University of Traditional Chinese Medicine
2025
Guang’anmen Hospital
2025
Hangzhou First People's Hospital
2016-2023
Nanjing Medical University
2016-2022
Fondazione IRCCS Istituto Nazionale dei Tumori
2020
Zhejiang Chinese Medical University
2018-2019
Hangzhou Medical College
2016
Androgen-deprivation therapy (ADT) via targeting androgens/androgen receptor (AR) signals may suppress cell proliferation in both prostate cancer (PCa) and bladder (BCa), yet its impact on the invasion of these two urological cancers remains unclear. Here we found androgens/AR with either recently developed antiandrogen Enzalutamide (Enz) or AR-shRNAs led to increase PCa invasion, decrease BCa invasion. Mechanistic dissection revealed that suppressing could result differential alterations...
Abstract KEYNOTE‐033 (NCT02864394) was a multicountry, open‐label, phase 3 study that compared pembrolizumab vs docetaxel in previously treated, programmed death‐ligand 1 (PD‐L1)‐positive, advanced non‐small cell lung cancer (NSCLC), with most patients enrolled mainland China. Eligible were randomized (1:1) to 2 mg/kg or 75 mg/m every weeks. Primary endpoints overall survival (OS) and progression‐free evaluated sequentially using stratified log‐rank tests, first PD‐L1 tumor proportion score...
Abstract Background Brain metastasis (BM) are a devastating consequence of lung cancer. This study was aimed to screen risk factors for predicting BM. Methods Using an in vivo BM preclinical model, we established series adenocarcinoma (LUAD) cell subpopulations with different metastatic ability. Quantitative proteomics analysis used and identify the differential protein expressing map among subpopulation cells. Q-PCR Western-blot were validate proteins vitro. The candidate measured LUAD...
Abstract Hand–foot skin reaction (HFSR), among the most significant adverse effects of sorafenib, has been limiting clinical benefits this frontline drug in treating various malignant tumors. The mechanism underlying such toxicity remains poorly understood, hence absence effective intervention strategies. In present study, we show that vascular endothelial cells are primary cellular target sorafenib-induced HFSR wherein soluble heparin-binding epidermal growth factor (s-HBEGF) mediates...
The anti-tumor effects of S-allylcysteine (SAC), a water-soluble garlic derivative, on human ovarian cancer cells have been previous studied in vitro and vivo models but the precise epigenetic molecular mechanisms are still unclear. This study aimed to investigate mechanism SAC. Human epithelial cell line A2780 was selected. Cell proliferation cycle analyzed. DNA methylation, methyltransferase (DNMT) activity, tumor suppressor gene expressions, as well protein expression were SAC could...
Micropapillary adenocarcinoma is one of the most aggressive histologic subtypes lung (LADC), and even a minor proportion micropapillary component (MPC) within LADC could contribute to poor prognosis. Comprehensive analysis genetic immunological features with different percentages MPC would help better understand cancer biology this subtype direct future treatments.We performed next-generation sequencing (NGS) for discovery cohort 43 patients whose tumors were micro-dissected separate non-MPC...
Nowadays, non-small cell lung cancer (NSCLC) is threatening the health of all mankind. Although many progresses on treatment have been achieved in past few decades, current methods are still traditional surgery, radiotherapy, and chemotherapy, which had poor selectivity side effects. Lower-toxicity more efficient treatments sore need. In this paper, a smart nanodelivery platform based photothermal therapy, immunotherapy was constructed. The nanoparticles composed novel agents, Mn-modified...
Aging | doi:10.18632/aging.202735. Zuhua Chen, Xiadong Li, Jiawei Shirong Zhang, Pengfei Zhou, Xin Yu, Yao Ren, Jiahao Wang, Lidan Yunjiang Baoliang Wu, Yanchun Hou, Ke Rongjun Tang, Yongguang Liu, Zhongxian Ding, Bin Yang, Qinghua Deng, Qin Lin, Nie, Zhaobin Cai, Shenglin Ma, Yu Kuang
Ethnopharmacology relevance: Jiedu Sangen Decoction (JSD), an empirical prescription of Traditional Chinese Medicine (TCM), has been reported to inhibit invasion and metastasis colon cancer in our previous study. The aim this study was investigate the mechanism JSD-triggered inhibition cancer. Methods:In vitro, AKT1 knockdown (si-AKT1) or overexpression (oe-AKT1) cells were successfully constructed both SW480 SW620 cell lines. Si-AKT1 oe-AKT1 then treated with without JSD. Cell invasion,...
BACKGROUND Acute myeloid leukemia (AML) is associated with a high relapse rate and poor prognosis. This study aimed to use weighted gene coexpression network analysis (WGCNA) of networks identify candidate prognostic biomarker genes in patients AML investigate the expression these human U937 cell line vitro. MATERIAL AND METHODS RNA-seq data were retrieved from Cancer Genome Atlas (TCGA) included bone marrow samples survival (N=151), who did not after treatment (N=119), (N=40)....
We hypothesized that survival varied significantly between retroperitoneal soft tissue sarcoma (STS) and extremity/trunk STS. This study explored the reasons for different outcomes identified patient characteristics survival.This retrospective 213 consecutive patients with localized primary STS from January 2002 to July 2013, including 47 (22.1%) 166 (77.9%). Local failure-free (LFFS), distant metastasis-free (DMFS) overall (OS) were constructed by Kaplan-Meier method. Univariate Cox...
Purpose: The removal of the giant breast fibroadenoma (GFA) with esthetic repair severe deformed is a surgical challenge. Materials and Methods: This was retrospective study data 10 patients GFAs who treated modified round block technique at Department Breast Surgery, Hangzhou First People's Hospital (Hangzhou, Zhejiang province, China) from March 2014 to June 2017. Preoperatively, according degree excess skin asymmetry, four-point approach designed. area between inner outer circles...