A5061090610- Immune Cell Function and Interaction
- Advancements in Battery Materials
- Electrocatalysts for Energy Conversion
- Pancreatic and Hepatic Oncology Research
- Schizophrenia research and treatment
- RNA Interference and Gene Delivery
- MicroRNA in disease regulation
- HIV Research and Treatment
- Plant nutrient uptake and metabolism
- Virus-based gene therapy research
- CO2 Reduction Techniques and Catalysts
- Psoriasis: Treatment and Pathogenesis
- Microbial Community Ecology and Physiology
- Acute Myeloid Leukemia Research
- Plant Molecular Biology Research
- Andrographolide Research and Applications
- Cytokine Signaling Pathways and Interactions
- Viral Infectious Diseases and Gene Expression in Insects
- Molecular Junctions and Nanostructures
- Coal and Its By-products
- Cancer Mechanisms and Therapy
- Brain Metastases and Treatment
- Pancreatitis Pathology and Treatment
- Sleep and related disorders
- Advanced Data Storage Technologies
Wenzhou Central Hospital
2018-2025
Wenzhou Medical University
2018-2025
Chinese Academy of Sciences
2024
Montreal Clinical Research Institute
2024
Emory University
2024
Nanjing Agricultural University
2024
Zhongshan Hospital
2023
Chaoyang University of Technology
2022
Zhejiang Chinese Medical University
2019-2021
Dalian University
2020-2021
Radiotherapy plays a critical role in treating esophageal cancer, but individual responses vary significantly, impacting patient outcomes. This study integrates machine learning-driven multimodal radiomics and transcriptomics to develop predictive models for radiotherapy sensitivity prognosis cancer. We applied the SEResNet101 deep learning model imaging transcriptomic data from UCSC Xena TCGA databases, identifying prognosis-associated genes such as STUB1, PEX12, HEXIM2. Using Lasso...
MicroRNAs (miRNAs) play important roles in the control of HIV-1 infection. Here, we performed RNAseq profilings miRNAs and mRNAs expressed CD4+ T-lymphocytes upon Our results reveal significant alterations expression profiles infected relative to uninfected cells. One markedly downregulated cells is miRNA-26a. Among putative targets miRNA-26a are CD59 receptor transcripts, which significantly upregulated T-cells. Addition mimics T-cells reduces at both mRNA surface protein levels, validating...
Plant root system is significantly influenced by high soil levels of ammonium nitrogen, leading to reduced elongation and enhanced lateral branching. In Arabidopsis, these processes have been reported be mediated phytohormones their downstream signaling pathways, while the controlling mechanisms remain elusive in crops. Through a transcriptome analysis roots subjected high/low treatments, we identified cytokinin oxidase/dehydrogenase encoding gene, CKX3, whose expression induced ammonium....
Enhancing the efficacy of immunotherapy in brain metastases (BrM) requires an improved understanding immune composition BrM and how this is affected by radiation dexamethasone. Our two-arm pilot study (NCT04895592) allocated 26 patients with to either low (Arm A) or high B) dose peri-operative dexamethasone followed pre-operative stereotactic radiosurgery (pSRS) resection (n= 13 per arm). The primary endpoint, a safety analysis at 4 months, was met. secondary clinical endpoints overall...
Statement of RetractionWe, the Editors and Publisher journal Cell Cycle, have retracted following article:Cheng-Yu Ye, Cui-Ping Zheng, Wei-Wei Ying, Shan-Shan Weng. Up-regulation microRNA-497 inhibits proliferation, migration invasion but increases apoptosis multiple myeloma cells through MAPK/ERK signaling pathway by targeting Raf-1. Cycle. 2018;17(24):2666-2683. doi:10.1080/15384101.2018.1542895.Since publication, significant concerns been raised about integrity data reported results in...
Electroreduction of CO2 is one the most promising conversion pathways because its moderate reaction conditions, controllable product composition, and environment-friendliness.However, current electroreduction technologies have not reached techno-economic threshold for a competitively profitable electrochemical process.Based on simple two-electron transfer process, to CO, which further processed into syngas with reduction H2O H2, postulated be pathway process.Such process urgently requires...
BACKGROUND Acute myeloid leukemia (AML) is associated with a high relapse rate and poor prognosis. This study aimed to use weighted gene coexpression network analysis (WGCNA) of networks identify candidate prognostic biomarker genes in patients AML investigate the expression these human U937 cell line vitro. MATERIAL AND METHODS RNA-seq data were retrieved from Cancer Genome Atlas (TCGA) included bone marrow samples survival (N=151), who did not after treatment (N=119), (N=40)....
The present study performed experiments to identify the superior pH for Arabidopsis root growth base on its development (radical length and lateral density); then approached mechanism by which optimized primes development. results showed that neutral slightly alkaline (7.0−8.0) in medium was optimum range plant had longer primary roots denser roots. Auxin reporter <italic>DII:VENUS</italic> transgenic line cultured standard (5.8) (7.5) indicated 7.5 conditions, there less fluorescence cap...
Background: Drug-induced parkinsonism (DIP) is the most prevalent neurological side effect of antipsychotics in Chinese population. Early prevention, recognition, and treatment DIP are important for improvement outcomes medication adherence schizophrenia patients. However, risk factors impact on clinical syndromes remain unknown. Aim: The goal this study was to explore factors, correlates, social functions Methods: A cross-sectional analysis a multicenter, observational, real-world,...
This paper intended to study RBPMS-AS1 in lung cancer (LC) radiosensitivity.LC cells were transfected with overexpression plasmid and miR-19a-3p mimic treated radiation. PTEN, AKT, p-AKT, RBPMS-AS1, expressions detected via Western blot qRT-PCR. The localization of was determined through fluorescence situ hybridization assay. targeting relationships miR-19a-3p/miR-19a-3p PTEN RIP dual luciferase reporter analysis. Cell survival, viability, apoptosis assessed colony formation, CCK-8,...
Abstract Non-small cell lung cancer (NSCLC), a commonly diagnosed cancer, is characterized by high incidence of metastatic spread to the brain, which adversely impacts prognosis. The present study aimed assess value combined dynamic contrast-enhanced MRI (DCE-MRI) and diffusion-weighted imaging (DWI) in predicting treatment outcomes whole-brain radiotherapy (WBRT) gefitinib brain metastases from non-small (NSCLC) perspectives response rate short- long-term efficacy. These results suggested...
Unlike monogastric animals, ruminants exhibit significantly lower starch digestibility in the small intestine. A better understanding of physiological mechanisms that regulate digestion patterns could lead to an increased use concentrates. Here we show more robust pancreatic exocrine function adult goats (AG) than neonatal (NG) by combining scRNA-seq and proteomic analysis. Our findings suggest inadequate amylase activity be a limiting factor ruminants. In addition, insufficient hydrolysis...
Schizophrenia patients have a high risk of suicide, and their cognition function is impaired with increasing age. The association between neurocognitive suicidality in schizophrenia are heterogeneous. We aimed to explore the relationship suicidal ideation across age groups.A total 587 were enrolled this study. divided into young group (aged 18-44) middle-aged elderly 45-70). non-suicidal according evaluation results Beck Scale for Suicide Ideation. Insomnia symptoms measured by Severity...
MicroRNAs (miRNAs) play important roles in the control of HIV-1 infection. Here, we performed RNA-seq profiling miRNAs and mRNAs expressed CD4