A5074012963- Antibiotic Resistance in Bacteria
- Vibrio bacteria research studies
- Bacterial biofilms and quorum sensing
- Bacterial Identification and Susceptibility Testing
- Environmental Chemistry and Analysis
- Escherichia coli research studies
- Drug Solubulity and Delivery Systems
- Mycobacterium research and diagnosis
- Enterobacteriaceae and Cronobacter Research
- Marine Biology and Environmental Chemistry
- Polymer Surface Interaction Studies
- Advanced Drug Delivery Systems
- vaccines and immunoinformatics approaches
- Pharmaceutical and Antibiotic Environmental Impacts
- Antibiotics Pharmacokinetics and Efficacy
- Infections and bacterial resistance
- Bacteriophages and microbial interactions
- Genomics and Phylogenetic Studies
University of Houston
2022-2023
Lebanese American University
2017-2020
Carbapenem-resistant Acinetobacter baumannii (CRAB) has been implicated in hospital outbreaks worldwide. Here, we present a whole-genome-based investigation of an extensively drug-resistant CRAB outbreak rapidly spreading and causing high incidences mortality at numerous wards large tertiary Lebanon. This is the first study its kind region. Two circulating clones were identified using combination molecular typing approaches, short- long-read sequencing Bayesian transmission network analysis....
Abstract Klebsiella pneumoniae is a Gram-negative organism and major public health threat. In this study, we used whole-genome sequences to characterize 32 carbapenem-resistant K. (CRKP) two quasipneumoniae (CRKQ). Antimicrobial resistance was assessed using disk diffusion E-test, while virulence in silico . The capsule type determined by sequencing the wzi gene. plasmid diversity PCR-based replicon typing detect incompatibility (Inc) groups. genetic relatedness multilocus sequence typing,...
The emergence of carbapenem resistant Escherichia coli represents a serious public health concern. This study investigated the resistome, virulence, plasmids content and clonality 27 E. isolated from hospitalized patients at American University Beirut Medical Center (AUBMC) in Lebanon between 2012 2016. Whole-genome sequencing (WGS) data were used to identify resistance determinants. Multilocus sequence typing (MLST), pulsed field gel electrophoresis (PFGE), phylogenetic grouping PCR-based...
Aim: To evaluate the effects of population influx refugees on prevalence extended-spectrum β-lactamase-producing Escherichia coli in wastewater networks Lebanon. Materials & methods: Pulsed-field gel electrophoresis, multilocus sequence typing and antibiotic resistance genes were performed. Results: 53.1% isolates recovered from Al-Qaa refugee camp positive for tested resistant determinants compared with 49.1% river effluents. All carried aac(6)-1b and/or aac(3)-II; none armA, rmtB,...
The rapid emergence of carbapenem-resistant Acinetobacter baumannii is a global health concern. A comparative genomic analysis was performed on two ST85 A. strains harboring blaNDM-1 and blaOXA-94 collected in Lebanon from Syrian Civil War victims.Genome sequencing data ACMH-6200 ACMH-6201 were used for silico extraction multilocus sequence types (MLST), resistance genes, virulence factors. Plasmids genetically mapped using PCR-based replicon typing (PBRT). genetic environment determined,...
The escalating problem of antibiotic resistance, specifically cabarpenemase and extended-spectrum β-lacatamase (ESBL) producing K. pneumoniae strains, is directly correlated with increased patient morbidity mortality prolonged hospitalization costs. In this study, a comprehensive genomic analysis encompassing the resistomics, virulence repertoire mobile genetic elements an NDM-1 positive ESBL-producing EA-MEH ST15 isolated from urine sample collected Syrian refugee was conducted. Illumina...
Plant-based polymers, as nanodrug delivery systems (NDDS), offer many benefits over synthetic ones. Optimizing the interactions of entrapped drug within NDDS material, loading capacity, transport behavior, physicochemical transformations, and release under realistic physiological conditions is crucial to ensure appropriate application NDDS. In this work, composed Zein nanoparticles with tuned hydrophobicity were synthesized by nanoprecipitation. Hydrophobicity was modified increasing or...
Escherichia coli is responsible for a wide variety of community and hospital acquired extraintestinal infections, the emergence ESBL resistant isolates major clinical concern. In this study, we characterized genomic attributes an OXA-48 CTX-M-3 producing E. EC-IMP153. Whole-genome initial assembly produced 146 contigs with combined 5,504,170 bp in size G+C content 50.5%. wgSNPs-based phylogenetic comparison 36 publically available genomes was also performed. Comprehensive analysis showed...