A5044340788- Air Quality and Health Impacts
- Air Quality Monitoring and Forecasting
- Health, Environment, Cognitive Aging
- Toxic Organic Pollutants Impact
- Vehicle emissions and performance
- Cancer Risks and Factors
- Nutritional Studies and Diet
- Effects and risks of endocrine disrupting chemicals
- Environmental Policies and Emissions
- Heavy Metal Exposure and Toxicity
- Carcinogens and Genotoxicity Assessment
- Skin Protection and Aging
- Environmental Justice and Health Disparities
- Climate Change and Health Impacts
- Radioactivity and Radon Measurements
- Global Public Health Policies and Epidemiology
- Occupational and environmental lung diseases
- Global Healthcare and Medical Tourism
- French Urban and Social Studies
- Effects of Radiation Exposure
- Noise Effects and Management
- Impact of Light on Environment and Health
- Atmospheric chemistry and aerosols
- Global Cancer Incidence and Screening
- Radiation Dose and Imaging
Centre Léon Bérard
2016-2025
Inserm
2019-2025
Centre de Recherche en Cancérologie de Lyon
2018-2025
Institut d’Hématologie et d’Oncologie Pédiatrique
2024
Service de Santé des Armées
2024
Ministère des Armées
2024
Université Claude Bernard Lyon 1
2017-2023
Centre National de la Recherche Scientifique
2019-2023
École Normale Supérieure de Lyon
2023
École Centrale de Lyon
2019-2022
Benzo[a]pyrene (BaP) is an endocrine-disrupting pollutant formed during incomplete combustion of organic materials. It has been recognized as a reproductive and developmental toxicant, however epidemiological evidence the long-term effect ambient air BaP on breast cancer (BC) limited. Thus we evaluated associations between exposure risk BC, overall according to menopausal status molecular subtypes (estrogen receptor negative/positive (ER−/ER+) progesterone (PR−/PR+)), stage grade...
Nitrogen dioxide (NO2) is an important air pollutant due to its adverse effects on human health. Yet, current evidence the association between NO2 and risk of breast cancer lacks consistency. In this study, we investigated long-term exposure in French E3N cohort study. Association with was assessed a nested case-control study within including 5222 cases identified over 1990-2011 follow-up period matched controls. Annual mean concentrations at participants' residential addresses for each year...
Outdoor exposure to particulate matter (PM2.5 and PM10) in urban areas can vary considerably depending on the mode of transport. This study aims quantify this difference during daily travel, by carrying out a micro-sensor measurement campaign. The pollutant was assessed simultaneously over predefined routes order allow comparison between different transport modes having same starting ending points. During six-week campaign, average reference values for PM background concentrations were 13.72...
Cadmium, due to its estrogen‐like activity, has been suspected increase the risk of breast cancer; however, epidemiological studies have reported inconsistent findings. We conducted a case–control study (4,059 cases and 4,059 matched controls) nested within E3N French cohort estimate cancer associated with long‐term exposure airborne cadmium pollution, effect according molecular subtype (estrogen receptor negative/positive [ER−/ER+] progesterone [PR−/PR+]). Atmospheric was assessed using...
Dioxins, Group 1 carcinogens, are emitted by industrial chlorinated combustion processes and suspected to increase breast cancer risk through receptor-mediated pathways.We estimated associated with airborne dioxin exposure, using geographic information system (GIS) methods historical exposure data.We designed a case-control study (429 cases diagnosed between 1990 2008, matched 716 controls) nested within the E3N (Etude Epidémiologique auprès de femmes la Mutuelle Générale l'Education...
An increasing evidence links air pollution to breast cancer (BC) risk. Yet, pollutant exposure estimates at the workplace location in assessment have not been considered.
Exposure to light at night (LAN), particularly blue light, is suspected disrupt circadian rhythm, inhibit melatonin production, and eventually increase the risk of breast cancer. We assessed association between exposure outdoor LAN cancer in E3N-Générations cohort, a large population-based cohort study French women followed-up from 1990 2011. conducted nested case-control including 5222 incident cases matched controls. Outdoor residential addresses was using radiance-calibrated satellite...
Dioxins are environmental and persistent organic carcinogens with endocrine disrupting properties. A positive association several cancers, including risk of breast cancer has been suggested. This study aimed to develop assess performances an exposure metric based on a Geographic Information System (GIS) through comparison validated dispersion model estimate historical industrial dioxin for its use in case-control nested within prospective cohort. Industrial sources were inventoried over the...
Breast cancer is the most frequent in women industrialized countries. Lifestyle and environmental factors, particularly endocrine-disrupting pollutants, have been suggested to play a role breast risk. Current epidemiological studies, although not fully consistent, suggest positive association of risk with exposure several International Agency for Research on Cancer Group 1 air-pollutant carcinogens, such as particulate matter, polychlorinated biphenyls (PCB), dioxins, Benzo[a]pyrene (BaP),...
Human exposure to air pollution involves complex mixtures of multiple correlated pollutants. To date, very few studies have assessed the combined effects pollutants on breast cancer (BC) risk. We aimed assess association between exposures and The study was based a case-control nested within French E3N cohort (5222 incident BC cases/5222 matched controls). For each woman, average mean annual eight (benzo(a)oyrene, cadmium, dioxins, polychlorinated biphenyls (PCB153), nitrogen dioxide (NO2),...
10572 Background: Human exposure to air pollution involves complex mixtures of multiple correlated pollutants. To date, very few studies have assessed the combined effect pollutants on breast cancer risk. We joint effects and Methods: The study was based a case-control nested within French E3N cohort, involving 5222 incident cases matched controls. For each woman, average mean annual concentration estimates for eight ((benzo(a)pyrene, cadmium, dioxins, polychlorinated biphenyls (PCB153),...
Abstract Molecular studies suggest that cadmium due to its estrogenic properties, might play a role in breast cancer (BC) progression. However epidemiological evidence is limited. This study explored the association between long-term exposure airborne and risk of BC by stage, grade differentiation, histological types at diagnosis. A nested case–control 4401 cases matched controls was conducted within French E3N cohort. Geographic Information System (GIS)-based metric demonstrated reliably...
Numerous cancers develop years after subjects have been exposed to chemical compounds. Thus, environmental epidemiological studies need accurately reconstruct exposures over long periods. To estimate exposure NO2 and PM10 concentrations, we modelled ground-level air at very fine temporal (1 h) spatial (10 m) resolutions, a large European metropolitan area subject’s address of French national cohort, for five different (1990, 1995, 2000, 2005 2010). Model performances were assessed by...