Breast cancer is one of the worst diseases that affect female people. Long-term treatment with therapy or surgery has a detrimental impact on patient. The algae Kappaphycus alvarezii gotten lot interest as breast medication because it contains chemicals are expected to be anti-cancer. objectives this paper were see how secondary metabolites in interact Nuclear Factor- kappaB protein kinase cancer. ligands and proteins obtained from PubChem PDB websites, respectively. Swiss ADME was then used...

Numerous research on stunting supplementation interventions in Indonesia have been published. The information can be extracted through data mining, especially from academic databases. In this paper, we presented a text mining-based literature review strategy to create pipeline that researchers use accelerate the development of intervention Indonesia. Utilizing various NLP (Natural Language Processing) techniques, were crawled, processed, and visualized using Python. crawling dataset used...

Abstract Photosystem II (PSII) is the multi-subunit light-driven oxidoreductase that drives photosynthetic electron transport using electrons extracted from water. To investigate initial steps of PSII assembly, we used strains cyanobacterium Synechocystis sp. PCC 6803 arrested at early stages biogenesis and expressing affinity-tagged subunits to isolate reaction center assembly (RCII) complexes their precursor D1 D2 modules (D1mod D2mod). RCII preparations isolated either a His-tagged or...

Aflatoxin-B1 (AFB1) is a common contaminant for staple foods during the storage process. Chronic exposure to AFB1 widely known induce development of hepatocellular carcinoma (HCC). However, there lack understanding AFBi role in HCC mechanism. This research aims identify protein(s) that might interact with and predict pathway effected by AFB1. Analyses were performed using bioinformatics tools. SMILES notation was submitted into Swiss Target Prediction. Interaction among predicted proteins...

T cell immunity, like responses of CD4+and CD8+ T-cell, plays an important role to fight against viral infections and pathological harm. Several previous studies have shown the results that rabies virus (RABV) protein can act as ideal receptor for neuroseptic vaccine by inducing a response T-cell. In this research, we evaluated possible epitopes based on Rabies sequence human lymphocyte antigen (HLA) distribution. First, study used P obtained from NCBI database. Next, predicted CTL frequency...

One potential approach to improve the productivity of cyanobacteria and microalgae is enhance photosynthetic efficiency by introducing far-red absorbing pigment molecules (such as chlorophylls f d) into apparatus expand range photosynthetically active radiation. We have shown previously that expressing ChlF subunit Chroococcidiopsis thermalis PCC 7203 in model cyanobacterium Synechocystis sp. 6803 (Syn6803) sufficient drive production chlorophyll (Chl f), but only low levels (0.24% Chl f/Chl...

Abstract A novel putative D-allulose 3-epimerase (DAEase) named CcDAE with the accession number of WP_183335203.1 was discovered in this study from Chelatococcus composti genome using silico mining method. The sequence, which retrieved strain CGMCC 1.15283 and became first reported species. sequence length 282 aa a molecular weight prediction 30.504 kDa. analysis disclosed high conservation at residues building metal binding site substrate site. phylogenetic tree also that closest related...

There is a need to produce more crop plants meet the future global demand. However, climate change has affected yield. Consequently, finding an alternative approach improve yield becomes essential. The development of sequencing techniques, as well information technologies, have enabled us perform genome data mining. Using mining approach, it possible identify or discover protein which particular characteristic. This study aims protein, could potentially yield, using approach. D1 was used...

Abstract Virgibacillus salarius 19.PP.SC1.6 is a coral symbiont isolated from Indonesia's North Java Sea; it has the ability to produce secondary metabolites that provide survival advantages and biological functions, such as ectoine, which synthesized by an ectoine gene cluster. Apart being osmoprotectant for bacteria, also known chemical chaperone with numerous activities maintaining protein stability, makes in high demand market industry beneficial investigate V. ectoine. However, there...

Typhoid fever is an endemic disease that burdens Indonesia and has a potentially fatal infection multisystem. Salmonella typhi bacterium responsible for typhoid disease. Poor sanitation, crowding, slums are the main factors of increasing incidences. Environmental directly connected to meteorological factor in breeding bacterium. This study aims identify correlation between parameters occurrence. The was carried out Jakarta, Indonesia, Bureau Meteorological, Climatology, Geophysics (BMKG)...

Abstract Given the continuous increase in world population, producing more food is necessary. The majority of people across consume rice as main food. Thus, it essential to produce plants be able feed growing population. Molecular biology techniques have advanced rapidly, allowing exploration and discovery various by examining their DNA genome, which called barcoding. This paper aims develop a pipeline for identification utilizing barcoding approach. We chose rbcL gene target region Then, we...

<title>Abstract</title> <bold>S</bold>tunting poses a major issue in many developing countries, including Indonesia, with the lack of dietary intake as one main driving factors. Further, prevalence stunting Indonesia is still considered high, which was recorded to be about 24.4% 2021. Each local government tried give food an extra supplementation support fostering reduction. However, impact treatment using from needs elucidated. Hence, this study aims register children Serdang Bedagai...

Quantifying the effect of mutations in BRCA1 gene is useful for understanding their clinical consequences on breast cancer. Machine learning models can be applied to predict landscape protein variant effects that might not always accessible by experiments. In this work, we propose a simple semi-supervised method using Gaussian mixture model ∼90% unlabeled missense variants collected from ClinVar database. High-quality embeddings are used as feature sequences, extracted latest pre-trained...

Dengue fever is mainly caused by female mosquitoes from the genus Aedes. It predominantly occurs in equatorial to sub-tropical regions. The weather factors play a significant role mosquito life cycle, so study on impact of climate parameters dengue incidence required. This aimed understand statistical association between annual fluctuation cases with Indonesia. Climatic data, rainfall, and mean ambient temperature Indonesia were obtained climateknowledgeportal.worldengueank.org 2010 2020,...

Abstract. Siallagan ZL, Kristianti T, Dwivany FM, Nugrahapraja H, Fretes CED, Fadli M, Trinugroho JP, Radjasa OK, Susanto RD. 2023. Vertical profile of culturable bacteria from the Makassar Strait, Indonesia. Biodiversitas 24: 1356-1365. Indonesia's extensive maritime background is a rich biological and chemical diversity source. This has become as source unique compounds with potential for industrial development enzymes, molecular probes, chemicals, pharmaceuticals, cosmetics, nutritional...

As the global demand for food continue to increase, it is important find a way meet without creating any problems environment. Cyanobacteria have prospective be utilised modern agriculture, as they contribute improvement of soil fertility, crop yield, and also do not harm Therefore, crucial understand species cyanobacteria or characteristics that could used agriculture. The development Next-Generation Sequencing (NGS) technologies enables us study genome cyanobacteria. Thus, we can their by...

Tuberculosis (TB) is one of the highest causes death in Indonesia. The main reason lack health facilities. Computer-aided diagnosis (CAD) a tool for early treatment and screening many diseases, including TB. This paper proposed design CAD system Indonesia specifically gives analysis self-assessment concepts, use-case diagrams, black-box diagrams. black box utilizes chest x-ray (CXR) data medical image processing (MIP) method, artificial intelligence (AI) classification visualization TB has...

Abstract Trehalose is a type of sugar that known by its stability and resilience towards acid low temperature. Furthermore, trehalose has numerous health benefits been used several industries, including food, cosmetics, pharmaceuticals. Even though could be easily produced using synthase (TreS) enzyme, sustainable production still problem. Our work aims to develop an approach identify novel enzyme from various organisms, especially thermophilic bacteria, implementing deoxyribonucleic (DNA)...

Many countries are still dependent on fossil fuels as their primary energy supply. However, there is a growing concern about the sustainability and environmental issue of fuels. Therefore, it important to utilize renewable resources supply, such solar energy. As country with tropical climate, Indonesia has great potential use energy, due abundance sunlight exposure. The present study aims analyze several meteorological parameters for installation photovoltaic (PV) technology in Jakarta,...

Monoglyceride and diglyceride are known as emulsifiers that have been used in the food industry. Furthermore, both mono also potential to be utilized antibacterial compounds. Both of them can produced from natural source, such palm kernel oil, via glycerolysis reaction. This study aims determine effect temperature time reaction on composition their capability an agent. a split-plot design with main plot (80°C, 90°C, 100°C) subplot (3, 4, 5 hours). Several parameters were analyzed, including...

Population-specific studies reveal that cancer-related mechanisms of BRCA1 gene mutations may vary by ethnicity. The wealth public genomic data provides insight into the functional roles in diverse populations. In this study, we performed population differentiation analysis on biallelic SNPs located region using variant-calling from 1000 Human Genome Project. First, conducted an Analysis Molecular Variance (AMOVA) global populations to infer a three population-related hierarchical levels. An...

Abstract The government of Serdang Bedagai Regency initiated a supplementation program to reduce the high prevalence stunting in area by delivering extra supplementation, which were nutritious biscuits from national and fish-based supplement produced local resources. A 6-month study April 2022 September was conducted monitor evaluate that involved 219 under-5-year-old children with height-for-age Z-score (HAZ-score) below − 2. We observed reduction 37.00%, where 81 recovered (HAZ-score ≥ 2)....