A5077999725- Epigenetics and DNA Methylation
- Endometriosis Research and Treatment
- Assisted Reproductive Technology and Twin Pregnancy
- Ovarian cancer diagnosis and treatment
- Ovarian function and disorders
- Uterine Myomas and Treatments
- Reproductive Biology and Fertility
- Endometrial and Cervical Cancer Treatments
- Sexual Differentiation and Disorders
- Reproductive Health and Technologies
- Gestational Diabetes Research and Management
- Prenatal Screening and Diagnostics
- Vascular Malformations and Hemangiomas
- Enhanced Recovery After Surgery
- Cancer-related gene regulation
- Urological Disorders and Treatments
- PARP inhibition in cancer therapy
- MRI in cancer diagnosis
- Genetic Syndromes and Imprinting
- Cervical Cancer and HPV Research
- Minimally Invasive Surgical Techniques
- Renal and related cancers
- Pelvic and Acetabular Injuries
- BRCA gene mutations in cancer
- Nutrition and Health in Aging
Tokyo Women's Medical University
2017-2025
National Center For Child Health and Development
2018-2019
Since the laparoscopic surgical technique and quality for ovarian cystectomy largely depend on primary surgeon, we investigated usefulness feasibility of hanger retention bag (HRB) double suture (DSHT) as maneuvers to prevent tumor spillage, minimizing reliance surgeon's skill greatest extent possible. HRB DSHT present several advantages. First, requiring only a retrieval suture, are feasible, simple, cost-effective, can be performed at any facility with endoscopic equipment. Additionally,...
Urinary tract endometriosis affects 0.3-12 % of all cases endometriosis. Medications have limited efficacy in treating advanced disease. Serous cystadenofibroma is a rare benign variant ovarian epithelial tumors comprising both and fibrous stromal components. Its diagnosis challenging due to its visual resemblance malignancy. A patient diagnosed with ureteral underwent surgical excision the right kidney ureter. Ten years later, developed tumor suspected be malignant at same site. Following...
C3H mice have been frequently used in cancer studies as animal models of spontaneous liver tumors and chemically induced hepatocellular carcinoma (HCC). Epigenetic modifications, including DNA methylation, are among pivotal control mechanisms gene expression leading to carcinogenesis. Although information on somatic mutations is available, epigenetic aspects yet be clarified. We performed next generation sequencing-based analysis methylation microarray explore genes regulated by mice....
Chylous ascites is infrequently observed following lymph node dissection in surgeries for gynecological malignancies. If symptoms develop, they can severely debilitate patients and increase the risk of infection, particularly those with a low performance status primary operation. Treatment chylous often challenging protracted, no treatment currently guaranteeing complete cure. This study explores efficacy standby therapy refractory 46-year-old woman malignancies who did not respond to...
Squamous cell carcinoma of the endometrium is extremely rare, accounting for approximately 1% uterine body malignancies. The present report describes a case squamous arising from ichthyosis due to persistent pyometra. A 68-year-old Japanese woman, gravida 1 para 1, was referred Gynecological Department Tokyo Women's Medical University, watery brown vaginal discharge which had persisted 10 days. Pelvic magnetic resonance (MRI) imaging revealed tumorous lesion occupying cervical uteri,...
Background: Frasier syndrome (FS) is characterized by gonadal dysgenesis and progressive nephropathy caused mutation in the Wilm9s tumor gene (WT1). We report a case of FS which diagnosis was based on amenorrhea with nephropathy, laparoscopically-removed streak gonad revealed gonadoblastoma. Case Report: At age 3 years, patient developed nephrotic syndrome. This later became steroid-resistant and, 16 had progressed to end-stage renal failure peritoneal dialysis. 17 presented primary referred...
Ovarian metastasis (OM) from breast cancer accounts for 3‑38% of all ovarian neoplasms and is associated with various characteristic clinical presentations, such as pseudo‑Meigs syndrome Krukenberg tumor. Accurate diagnosis OM may be challenging, lesions are frequently asymptomatic until they reach a large size. Occasionally, metastatic detected prior to the primary Immunohistochemistry plays an important role in distinguishing tumors extraovarian tumor metastases helpful identifying site....
It is relatively uncommon to treat patients with a preoperative diagnosis of benign leiomyoma that then unexpectedly rediagnosed as malignant in postoperative histology. We report the case 55-year-old woman low-grade endometrial stromal sarcoma who had been diagnosed having uterine myxoid degeneration by magnetic resonance imaging (MRI). She underwent laparoscopic hysterectomy. The uterus, after being placed retrieval bag, was transvaginally morcellated prevent spillage contents, MRI image...
In type 2 diabetes patients, attempting oocyte retrieval for egg cryopreservation without having established glycemic control does not yield good results. Strict dietary treatment and appropriate insulin administration is the best way to pregnancy.
Background: Female sex hormones work in concert. Gonadotropin-releasing hormone and ovulation-inducing agents are required female patients with infertility owing to dysregulation. Although drug-induced follicular development can be expected endogenous deficiency, data lacking on the protocols drugs used. Methods: We retrospectively examined success rates of ovulation induction, assisted reproductive technology, pregnancy outcomes 66 cycles eight pituitary insufficiency at our hospital....
Introduction: At our facility, oocyte retrieval had previously been performed with a 20-gauge standard needle that is uniformly thin overall (tSN); but recently, we have instead started using reduced needles, tip and 17-gauge body (RN). Until now, there comparisons between RN thick no tSN. The purpose of this study was to compare outcomes Methodology: Information on extracted from the medical records 304 cycles at facility January 2020 December 2023. two types needles were compared...
Introduction: This observation study aimed to differentiate between lobular endocervical glandular hyperplasia (LEGH) and gastric-type mucinous carcinoma (GAS) while evaluating the feasibility efficacy of laparoscopic surgery in preoperative diagnosis cervical cystic lesions. Method Material: A retrospective was conducted evaluate diagnostic process surgical management lesions suspected be LEGH or GAS. Preoperatively postoperatively, MRI, cytology, histology, tumor marker analysis, outcomes...
In Tokyo, where the highest coronavirus disease 2019 (COVID-19) infection rates have been reported nationally, we introduced and performed polymerase chain reaction (PCR) testing on patients prior to them coming for oocyte retrieval (OR) or embryo transfer (ET) procedures. addition, recommended that self-inject ovarian stimulation drugs reduce number of hospital visits required. We aimed assess patient acceptance these measures change treatment number.We conducted a retrospective study...
Aim : to examine an efficacy of various stimulation methods in a group successful pregnancies. Materials and Methods . In single center retrospective study 47 pregnancy cases were examined after performing embryo transfers at our institution from the years 2017 2021. Patients divided into four groups: i) clomiphene hyperstimulation (CH), ii) with gonadotropin-releasing hormone (GnRH) agonist, iii) GnRH antagonist, iv) progestin-primed ovarian (PPOS). Age, anti-Mullerian hormone, presence...
Abstract Background With the development of assisted reproductive technology (ART), diseases believed to be caused by ART have begun identified as imprinted disease. However, no conclusion has been reached. So we sought determine whether procedures disturb gene methylation and genes alone are selectively disturbed. To examine constituents culture medium contribute changes in methylation, used a mouse model conduct IVF comprehensively analyzed 5′–C–phosphate–G–3′ (CpG) reduced representation...
Introduction: Prophylactic salpingectomy is increasingly being performed concurrently with hysterectomy to reduce the risk of future ovarian and fallopian tubal cancer. We report a case left cancer incidentally diagnosed during prophylactic at time total laparoscopic hysterectomy.