A5074948829- Cancer Cells and Metastasis
- Esophageal Cancer Research and Treatment
- Pancreatic and Hepatic Oncology Research
- Prostate Cancer Treatment and Research
- Cancer, Lipids, and Metabolism
- Intraperitoneal and Appendiceal Malignancies
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Ovarian cancer diagnosis and treatment
- Advancements in Transdermal Drug Delivery
- Cholesterol and Lipid Metabolism
- Lipoproteins and Cardiovascular Health
- Cancer Treatment and Pharmacology
- Immunotherapy and Immune Responses
- MicroRNA in disease regulation
- Hepatocellular Carcinoma Treatment and Prognosis
- Lung Cancer Research Studies
- Skin Protection and Aging
- Circular RNAs in diseases
- Esophageal and GI Pathology
- Cancer, Hypoxia, and Metabolism
- Medical Imaging and Pathology Studies
- Metastasis and carcinoma case studies
- 3D Printing in Biomedical Research
- Extracellular vesicles in disease
Wake Forest University
2022-2025
Rutgers, The State University of New Jersey
2020-2023
Creatv MicroTech (United States)
2021-2023
Forest Institute
2022
ORCID
2020
Abstract Background Cancer Associated Macrophage-Like cells (CAMLs) are polynucleated circulating stromal found in the bloodstream of numerous solid-tumor malignancies. Variations within CAML size have been associated with poorer progression free survival (PFS) and overall (OS) a variety cancers; however, no study has evaluated their clinical significance esophageal cancer (EC). Methods To examine this significance, we ran 2 year prospective pilot consisting newly diagnosed stage I-III EC...
Background: Cholesterol is an integral sterol lipid that influences the homeostatic maintenance of cellular structure, hormone synthesis, and metabolic regulation within cell. Accumulation intracellular cholesterol has shown to drive progression multiple human cancers. Here we report mutation or transcriptional repression exporter, ABCA1, a common phenomenon conserved in bowel cancers with novel mechanistic therapeutic implications. Methods: Whole-exome sequence analysis was conducted on 24...
Liquid biopsies have become an integral part of cancer management as minimally invasive options to detect molecular and genetic changes. However, current show poor sensitivity in peritoneal carcinomatosis (PC). Novel exosome-based liquid may provide critical information on these challenging tumors. In this initial feasibility analysis, we identified exosome gene signature 445 genes (ExoSig445) from colon patients, including those with PC, that is distinct healthy controls.Plasma exosomes 42...
Despite advancements in the early-stage detection and expansion of treatments for prostate cancer (PCa), patient mortality rates remain high patients with aggressive disease overtreatment indolent remains a major issue. Prostate-specific antigen (PSA), standard PCa blood biomarker, is limited its ability to differentiate subtypes resulting non-aggressive disease. Here we assess engorged cancer-associated macrophage-like cells (CAMLs), ≥50 µm, cancer-specific, polynucleated circulating cell...
Abstract Background: Appendiceal cancer (AC) is an orphan malignancy with only 1-2 cases per 100,000 people in the US. The genomic composition of metastatic, mucinous AC yet to be resolved at whole exome level and few groups have assessed clinical actionability target genes. Here we performed whole-exome sequencing (WES) on specimens 1) elucidate mutational spectrum AC, 2) identify recurrent mutations frequencies unique or common colorectal (CRC), 3) uncover that are associated patient...
Abstract Background: Cancer Associated Macrophage-Like cells (CAMLs) are polynucleated circulating stromal found in the bloodstream of numerous solid-tumor malignancies. Variations within CAML size have been associated with poorer progression free survival (PFS) and overall (OS) a variety cancers; however, no study has evaluated their clinical significance esophageal cancer (EC). Methods: To examine this significance, we ran two-year prospective pilot consisting newly diagnosed stage I-III...
3039 Background: Patients with multiple organ metastases have poorer prognoses than those a single metastasis, are frequently associated drug resistance, and higher tumor burden. Engorged (≥50um) Cancer Associated Macrophage-Like Cells (CAMLs) circulating stromal cell subtype detected in the blood of patients solid tumors at high risk for recurrence or progression. While numerous studies shown that ≥50um CAMLs predict poor clinical outcomes, meta-analysis these also suggested hyper engorged...
3051 Background: Cancer Associated Macrophage-Like cells (CAMLs) are a recently described circulating stromal cell common in the peripheral blood of patients with solid tumors. In non-small lung carcinoma (NSCLC), CAMLs ≥50µm after completion chemoradiation therapy (CRT) have been shown to worse progression free survival (PFS). However, recent addition anti-PD-L1 therapies conjunction CRT as standard care, it has never yet be evaluated whether remain predictive for monitoring NSCLC post...
Abstract Background: Cancer Associated Macrophage-Like cells (CAMLs) are polynucleated circulating stromal found in the bloodstream of numerous solid-tumor malignancies. Variations within CAML size have been associated with poorer progression free survival (PFS) and overall (OS) a variety cancers; however, no study has evaluated their clinical significance esophageal cancer (EC). Methods: To examine this significance, we ran two-year prospective pilot consisting newly diagnosed stage I-III...
Abstract Background: Cancer Associated Macrophage-Like cells (CAMLs) are polynucleated circulating stromal found in the bloodstream of numerous solid-tumor malignancies. Variations within CAML size have been associated with poorer progression free survival (PFS) and overall (OS) a variety cancers; however, no study has evaluated their clinical significance esophageal cancer (EC). Methods: To examine this significance, we ran two-year prospective pilot consisting newly diagnosed stage I-III...
Abstract Despite advancements in the early-stage detection and expansion of treatments for Prostate Cancer (PCa), patient mortality rates remain high patients with aggressive disease, overtreatment indolent disease remains a major issue. Specific Antigen (PSA), standard PCa blood biomarker, is limited its ability to differentiate subtypes resulting non-aggressive disease. Recently Associated Macrophage-Like cells (CAMLs), cancer-specific polyploid circulating stromal cell was found PCa....
Abstract Background: Prostate cancers (PC) are intrinsically complex, with few prognostic biomarkers that differentiate aggressive and indolent disease. Cancer associated macrophage like cells (CAMLs) have shown to be significant independent indicators for poor survival in tumors if engorged ≥50μm. However, no group has examined CAMLs' PC. In this prospective pilot study, we analyzed PSA & ≥50μm CAML presence (n=51) Stage I-III (n=41) metastatic PC (mPC) prior the start of new treatments...