A5008768528- Congenital Heart Disease Studies
- Neonatal Respiratory Health Research
- Congenital Diaphragmatic Hernia Studies
- Cardiovascular Conditions and Treatments
- Mechanical Circulatory Support Devices
- Neonatal and fetal brain pathology
- Neuroscience of respiration and sleep
- Esophageal and GI Pathology
- Aortic Disease and Treatment Approaches
- Biomedical Research and Pathophysiology
- Tracheal and airway disorders
- Blood Coagulation and Thrombosis Mechanisms
- Cardiac pacing and defibrillation studies
- Monoclonal and Polyclonal Antibodies Research
- Intestinal and Peritoneal Adhesions
- Cardiac Arrest and Resuscitation
- Cardiac Structural Anomalies and Repair
- Systemic Lupus Erythematosus Research
- Cardiac electrophysiology and arrhythmias
- Educational Games and Gamification
- Pharmaceutical studies and practices
- Renal function and acid-base balance
- Aortic aneurysm repair treatments
- Intestinal Malrotation and Obstruction Disorders
- Neonatal Health and Biochemistry
National University of Singapore
2020-2024
Duke-NUS Medical School
2021-2024
KK Women's and Children's Hospital
2014-2024
Singapore College of Traditional Chinese Medicine
2024
Yahoo (United Kingdom)
2015
Royal Brompton Hospital
2013
Boston Children's Hospital
2013
Cambridge University Hospitals NHS Foundation Trust
2011
Abstract Background Knowledge and skills decline within months post simulation-based training in neonatal resuscitation. To empower ‘Millennial’ learners to take control of their own learning, a single-player, unguided web-based Neonatal Resuscitation Game was designed. The present study investigates the effectiveness game on retention resuscitation knowledge skills. Methods evaluated 162 healthcare professionals who attended Following standard training, participants were assigned either...
Objectives To evaluate serial tissue Doppler cardiac imaging (TDI) in the evolution of bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH) among extremely preterm infants. Design Prospective observational study. Setting Single-center, tertiary-level neonatal intensive care unit. Patients Infant born <28 weeks gestation. Main outcome measures Utility TDI early diagnosis and prediction BPD-PH optimal timing for screening BPD-PH. Results A total 79 infants were...
Flecainide acetate is a Vaughan-Williams class IC antiarrhythmic drug prescribed for the treatment of supraventricular arrhythmias. It has narrow therapeutic index and proarrhythmic effects even at doses. metabolized by CYP2D6 enzyme that exhibits polymorphism. In this case report, we present, to our best knowledge, first toxicity contributed genetic polymorphism in an infant. Our patient with recurrent tachycardia was treated dose flecainide but developed heart block requiring...
The cooccurrence of congenital diaphragmatic hernia and oesophageal atresia with distal tracheo-oesophageal fistula is very rare carries high mortality. Very few anecdotal case reports one series have been reported in the literature. We report a late preterm, low birth weight infant this association who was successfully managed by staged surgical approach had good outcome.
Spontaneous neonatal aortic thrombus is rare. Clinical presentation can vary depending on the location of thrombus. We report a case premature infant with ischemic bowel likely due to an thromboembolic event. The had presented acute abdomen, and underwent exploratory laparotomy for concerns worsening necrotizing enterocolitis. Intra-operative findings were suggestive segmental small thrombosis mesenteric vessels subsequent Doppler ultrasound revealed infra-renal He was treated subcutaneous...
Venous thromboembolism remains one of the important causes pulmonary hypertension in children. The venous are varied and include antiphospholipid antibody syndrome (APS). Catastrophic APS (CAPS) is a severe variant characterised by disseminated thrombosis microangiopathy resulting multiorgan failure. CAPS can occur independently (primary APS) but mainly occurs association with systemic lupus erythematosus including paediatric population. We report young girl primary who presented an inferior...
A female baby, second of a monochorionic diamniotic pregnancy was born at 34 weeks gestation via vaginal delivery. Birth weight 2400 g. During the antenatal period mother had gestational diabetes requiring insulin therapy. The baby admitted to neonatal unit for continuous positive airway pressure support respiratory distress, which improved within 4 h. At around 24 h life she noted have large amount non-bilious gastric aspirates and abdominal distension. An …
Background: Patent ductus arteriosus (PDA) causing significant left to right shunt can increase key morbidities in preterm infants. Yet, treatment does not improve outcomes and spontaneous closure is the natural course of PDA. The Impact PDA on 23–26-week gestation infants uncertain. Selective such would likely balance outcomes. Objective: To test hypothesis that high-risk VLBW [birth weight ≤800 g or <27 weeks, hemodynamically significant, ductal diameter (DD, ≥1.6 mm), mechanical...
Background: Umbilical cord arterial lactate is a surrogate marker for fetal hypoxia. A poor often portends poorer neurological outcomes. Currently, there no universally accepted threshold normal lactate. Methodology: retrospective case–control study of 1978 neonates born in tertiary women’s and children’s hospital with neonatal intensive care unit was conducted from July 1, 2022, to December 31, 2022. The primary outcome evaluating the utility predict Secondary outcomes included comparing...
Introduction: Bronchopulmonary dysplasia (BPD) is a common respiratory morbidity in preterm infants. The onset of pulmonary hypertension leads to worse outcomes. contribution left ventricular diastolic dysfunction BPD-PH well reported. We evaluated the serial (LV) function and possible interdependence among BPD-PH. Methods: Single-centre, prospective observational study. Infants <28 weeks gestation included. Results: 80 infants were enrolled. incidence was 23%. group had high...
Glucose 6-phosphate dehydrogenase (G6PD) deficiency increases the risk of severe neonatal hyperbilirubinemia. This study evaluates factors predicting need for phototherapy in G6PD-deficient neonates after 72 h age and assesses safety early discharge.A retrospective cohort 681 full-term infants with a birth weight ≥2,500 g over 4 years was conducted. We compared baseline characteristics, bilirubin level on day (after life), peak bilirubin, G6PD levels, concomitant ABO incompatibility between...
<h3>Objective</h3> The purpose of this study was to evaluate the accuracy antenatal detection serious congenital heart disease (SCHD) in a low risk population. <h3>Study design</h3> An ongoing prospective descriptive over period 13 years. Patients were identified from local obstetric, neonatal and paediatric cardiac databases. Details all suspected fetal SCHD detected during routine ultrasound anomaly scans by ultrasonographers prospectively recorded suspicious pregnancies referred for...
<h3>Background</h3> Severe intraventricular haemorrhage (IVH, Papile’s Grades 3 and 4) can cause significant neurodevelopmental impairment in 43% of affected infants. <h3>Objectives</h3> The objectives this study were to the risk factors for severe IVH evaluate validity an prevention bundle VLBW infants a tertiary care centre with very low incidence IVH. <h3>Methods</h3> All born between January 2013 December 2018 included study. Data was collected from prospectively maintained database...
Aim: To ascertain the efficacy of late paracetamol therapy in managing haemodynamically significant patent ductus arteriosus (hsPDA) very low birth weight (VLBW) infants and correlate echocardiographic findings with clinical outcome.