A5024224377- Neonatal Respiratory Health Research
- COVID-19 Impact on Reproduction
- Neonatal and Maternal Infections
- Respiratory viral infections research
- Congenital Diaphragmatic Hernia Studies
- Maternal Mental Health During Pregnancy and Postpartum
- Streptococcal Infections and Treatments
- Single-cell and spatial transcriptomics
- Infant Development and Preterm Care
- Infant Nutrition and Health
- Immune responses and vaccinations
- Neonatal and fetal brain pathology
- Sepsis Diagnosis and Treatment
- Global Maternal and Child Health
- Tuberculosis Research and Epidemiology
- COVID-19 and Mental Health
- Vaccine Coverage and Hesitancy
- Pneumonia and Respiratory Infections
- Central Venous Catheters and Hemodialysis
- SARS-CoV-2 and COVID-19 Research
- Respiratory Support and Mechanisms
- Mosquito-borne diseases and control
- Antimicrobial Resistance in Staphylococcus
- Congenital Heart Disease Studies
- Neuroscience of respiration and sleep
KK Women's and Children's Hospital
2016-2025
Duke-NUS Medical School
2018-2024
UNSW Sydney
2024
Khoo Teck Puat Hospital
2024
National University Hospital
2024
Singapore General Hospital
2024
National University of Singapore
1985-2024
Singapore College of Traditional Chinese Medicine
2020-2024
Weatherford College
2023
Nanyang Technological University
2020-2023
To describe the trend and risk factors for severe intraventricular haemorrhage (IVH) among infants <32 weeks gestation.Population-based cohort study.Australia New Zealand.All preterm gestation in Australian Zealand Neonatal Network (ANZNN) from 1995 to 2012.Comparison of IVH incidence between 6-year epochs.Overall incidence.A total 60 068 were included, overall survival discharge increased 89% 93% over three epochs. As percentage with decreased 23.6% 21.3% 21.4% (p<0.001) epoch 1 3,...
There is limited information on the functional neutralizing capabilities of breastmilk SARS-CoV-2-specific antibodies and potential adulteration with vaccine mRNA after SARS-CoV-2 vaccination. We conducted a prospective cohort study lactating healthcare workers who received BNT162b2 their infants. The presence antibodies, antibody isotypes (IgG, IgA, IgM) intact in serum was evaluated at multiple time points using surrogate assay, ELISA, PCR, over 6 week period two-dose vaccination given 21...
Vaccination is critical in controlling the coronavirus disease 2019 (COVID-19) pandemic. However, vaccine perception and acceptance among pregnant lactating women unknown Singapore. We aimed to determine of COVID-19 vaccination these two groups Singapore factors associated with acceptance.
To examine the risk of mortality and major morbidities in extremely preterm multiple gestation infants compared with singletons over time.This is a retrospective study 15,402 born ≤27 weeks' gestation, admitted to NICUs Australian New Zealand Neonatal Network from 1995 2009. Mortality were between multiples across three 5-year epochs.Extreme more likely have lower birth weight; higher maternal age; rates assisted conception, antenatal steroid use, cesarean delivery singletons. The rate was...
Objective To determine the risk factors for mortality associated with late onset sepsis (LOS) among preterm very-low-birthweight (VLBW) infants. Study Design We performed a retrospective cohort study of infants born &lt;32 weeks gestation and &lt;1,500 gm admitted to Singaporean tertiary-level neonatal intensive care unit. determined clinical, microbial, laboratory due culture-positive LOS in this cohort. Results A total 1,740 were admitted, which 169 (9.7%) developed 27 (16%) died....
Abstract Introduction Vaccination is critical in controlling the coronavirus disease 19 (COVID-19) pandemic. However, vaccine perception and acceptance among pregnant lactating women unknown Singapore. We aimed to determine of COVID-19 vaccination these two groups Singapore, factors associated with acceptance. Methods conducted an anonymous, online survey on at a tertiary hospital Singapore from 1 st March 31 May 2021. Information demographics knowledge were collected, assessed for their...
Abstract Background There is a current, absence of reliable, blood-sparing, diagnostic tools to measure and trend real-time changes in the levels inflammation its effects on immune cells infant. Methods We deployed B iophysica L I mmune P rofiling for nfants (BLIPI) system neonatal intensive care unit describe cell biophysical profiles using 50 microliters blood per sample from term preterm infants. Results A total 19 infants (8 term, 11 preterm) were recruited 24 samples collected their...
ABSTRACT IgG antibodies to Plasmodium falciparum are transferred from the maternal fetal circulation during pregnancy, wane after birth, and subsequently acquired in response natural infection. We examined dynamics of malaria antibody responses 84 Kenyan infants birth 36 months age by (i) serology, (ii) variant surface antigen (VSA) assay, (iii) growth inhibitory activity (GIA), (iv) invasion inhibition assays (IIA) specific for merozoite protein 1 (MSP1) sialic acid-dependent pathway....
Abstract Background Gut dysbiosis contributes to the high risk of bloodstream infection (BSI) among premature infants. Most prior studies infant gut microbiota were conducted in Western countries and development current tools for strain-resolved analysis. Methods We performed metagenomic sequencing weekly fecal samples from 75 infants at a single hospital Singapore. evaluated associations between clinical factors composition using PERMANOVA mixed effects linear regression. used inStrain...
Objective To describe the risk of death and hospitalisation until adolescence children after group B streptococcus (GBS) infection during infancy. Design Population-based cohort study. Setting New South Wales, Australia. Patients All registered live births from 2000 to 2011. Interventions Comparison long-term outcomes in with International Statistical Classification Diseases Related Health Problems-10th Revision discharge codes corresponding GBS infections those without. Main outcome...
Serratia marcescens (S. marcescens) is associated with nosocomial infections significant morbidity and mortality in the neonatal intensive care units (NICU). We describe control of a multi-clonal S. outbreak our tertiary-level NICU application molecular typing using repetitive element palindromic PCR (rep-PCR) next generation sequencing (NGS) investigation. Outbreak investigation was performed where clinical, spatial epidemiologic links were established. Screening all infants environment...
Of the more band-efficient constant envelope digital modulations, duobinary FM is attractive in terms of its potential error performance, as indicated by minimum distance signal structure. In this paper, performance narrow-band FM, with discriminator detection an additive Gaussian noise background, evaluated for a range system bandwidths <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">BT</tex> and frequency deviation ratios...
The attitudes of neonatologists towards the active management extremely premature infants in a developing country like China are uncertain.A web-based survey was sent to from 16 provinces representing 59.6% (824.2 million) total population on October 2015 and December 2017.A 117 219 responses were received 2017, respectively. Compared 2015, respondents 2017 more likely resuscitate <25 weeks gestation (86% vs. 72%; p < 0.05), but few would ≤23 either epoch (10% 6%). In both epochs, parents...
Objectives To evaluate serial tissue Doppler cardiac imaging (TDI) in the evolution of bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH) among extremely preterm infants. Design Prospective observational study. Setting Single-center, tertiary-level neonatal intensive care unit. Patients Infant born &lt;28 weeks gestation. Main outcome measures Utility TDI early diagnosis and prediction BPD-PH optimal timing for screening BPD-PH. Results A total 79 infants were...
Internationally-adopted children are a unique group of Bacille Calmette-Guérin (BCG)-vaccinated with high rates latent tuberculosis infection (LTBI) in whom serial tuberculin skin tests (TST) recommended. No study has measured the incidence TST conversion these children.
Abstract Meteorological drivers are known to affect transmissibility of respiratory viruses including syncytial virus (RSV), but there few studies quantifying the role these drivers. We used daily RSV hospitalization data estimate effective reproduction number ( R t ), a real-time measure transmissibility, and examined its relationship with environmental in Singapore from 2005 through 2015. multivariable regression models quantify proportion variance explained by each meteorological driver....