About
Contact & Profiles
A5101990541
Research Areas
- Neuroinflammation and Neurodegeneration Mechanisms
- Adenosine and Purinergic Signaling
- Selenium in Biological Systems
- Neuroscience and Neuropharmacology Research
Abstract Acute brain slices represent a “workhorse” model for studying the central nervous system (CNS) from nanoscale events to complex circuits. While slice preparation inherently involves tissue injury, it is unclear how microglia, main immune cells and damage sensors of CNS shape integrity ex vivo . To this end, we have studied mechanisms microglial phenotype changes contribution neuronal network organisation functioning in acute slices. Using novel ATP- reporter mouse line microglia...
10.1101/2022.04.12.487998
preprint
EN
cc-by
bioRxiv (Cold Spring Harbor Laboratory)
2022-04-15
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