A5008130872- Microfluidic and Capillary Electrophoresis Applications
- Innovative Microfluidic and Catalytic Techniques Innovation
- Spine and Intervertebral Disc Pathology
- Wound Healing and Treatments
- Tissue Engineering and Regenerative Medicine
- Layered Double Hydroxides Synthesis and Applications
- Osteoarthritis Treatment and Mechanisms
- Bone Tissue Engineering Materials
- Aortic Disease and Treatment Approaches
- Medical Imaging and Analysis
- Protease and Inhibitor Mechanisms
- Virus-based gene therapy research
- Bone fractures and treatments
- Cell Adhesion Molecules Research
- Nerve injury and regeneration
- Proteoglycans and glycosaminoglycans research
- Platelet Disorders and Treatments
- Spinal Cord Injury Research
- Electrospun Nanofibers in Biomedical Applications
- biodegradable polymer synthesis and properties
- Microfluidic and Bio-sensing Technologies
- Antimicrobial Peptides and Activities
- RNA Interference and Gene Delivery
Royal College of Surgeons in Ireland
2019-2022
Ollscoil na Gaillimhe – University of Galway
2019-2021
Trinity College Dublin
2019-2020
Advanced Materials and BioEngineering Research
2019
Dublin City University
2018
Nonviral vectors offer a safe alternative to viral for gene therapy applications, albeit typically exhibiting lower transfection efficiencies. As result, there remains significant need the development of nonviral delivery system with low cytotoxicity and high efficacy as tool transient delivery. This study assesses MgAl-NO3 layered double hydroxide (LDH) vector deliver nucleic acids (pDNA, miRNA siRNA) mesenchymal stromal cells (MSCs) in 2D culture using 3D tissue engineering scaffold...
Positively charged oligo(poly(ethylene glycol) fumarate) (OPF+) hydrogel scaffolds, implanted into a complete transection spinal cord injury (SCI), facilitate permissive regenerative environment and provide platform for controlled observation of repair mechanisms. Axonal regeneration after SCI is critically dependent upon nutrients oxygen from newly formed blood supply. Our objective was to investigate fundamental characteristics revascularization in association with the ingrowth axons...
Diabetic foot ulcers (DFU) are chronic wounds sustained by pathological fibroblasts and aberrant extracellular matrix (ECM). Porous collagen-based scaffolds (CS) have shown clinical promise for treating DFUs but may benefit from functional enhancements. Our previous work showed differentiated induced pluripotent stem cells an effective source of new ECM mimicking fetal matrix, which notably promotes scar-free healing. Likewise, functionalizing CS with this rejuvenated potential DFU Here, we...
Abstract Positively charged oligo-polyethylene glycol fumarate (OPF+) hydrogel scaffolds, implanted into a complete transection spinal cord injury (SCI), facilitate permissive regenerative environment and provide platform for controlled observation of repair mechanisms. Axonal regeneration after SCI is critically dependent upon the availability nutrients oxygen from newly formed blood supply. In this study, objective was to investigate fundamental characteristics revascularization in...