A5084833463- Advanced Radiotherapy Techniques
- Cervical Cancer and HPV Research
- Global Cancer Incidence and Screening
- Cancer Diagnosis and Treatment
- Endometrial and Cervical Cancer Treatments
- Breast Cancer Treatment Studies
- Head and Neck Cancer Studies
- COVID-19 and healthcare impacts
- Ionosphere and magnetosphere dynamics
- Breast Lesions and Carcinomas
- Ovarian cancer diagnosis and treatment
- DNA Repair Mechanisms
- Effects of Radiation Exposure
- Geophysics and Gravity Measurements
- Radiation Therapy and Dosimetry
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Molecular Biology Techniques and Applications
- Colorectal and Anal Carcinomas
- Economic and Financial Impacts of Cancer
- Cell death mechanisms and regulation
- Autopsy Techniques and Outcomes
- Management of metastatic bone disease
- Advanced Breast Cancer Therapies
- Cancer Risks and Factors
- Radiation Dose and Imaging
Homi Bhabha National Institute
2021-2025
Tata Memorial Hospital
2021-2025
SRM Institute of Science and Technology
2025
Bhabha Hospital
2021-2024
Advanced Centre for Treatment, Research and Education in Cancer
2021-2024
Tribhuvan University Teaching Hospital
2024
Banaras Hindu University
2013-2022
Institute of Medical Sciences
2012-2022
Cancer Hospital and Research Institute
2020
Indian Institute of Technology BHU
2016-2019
Abstract Background Cancer incidence and mortality vary across the globe, with nearly two-thirds of cancer-related deaths occurring in low- middle-income countries. The rural-urban disparity socio-demographic, behavioural, lifestyle-related factors, as well access to cancer care, is one contributing factors. Population-based registries serve a measure for understanding burden cancer. We aimed evaluate care patients registered by an Indian population-based registry. Methods This study...
Minichromosome Maintenance (MCM) proteins play important roles in cell cycle progression by mediating DNA replication initiation and elongation. Among 10 MCM homologues 2–7 form a hexamer assemble to the pre-replication complex acting as licensing factors. Binding function of MCM2-7 is regulated MCM10 mediated binding RECQL4 with MCM2-7. The purpose this study explore role MCMs cervical cancer their correlation clinical parameters cancer. We have investigated sixty primary tissue samples,...
Abstract PARP1 trapping at DNA lesion by pharmacological inhibitors has been exploited in several cancers exhibiting defects repair mechanisms. hyperactivation is involved therapeutic resistance multiple cancers. The role of cervical cancer (CC) and implication PARP inhibitor yet to be elucidated. Our data demonstrates significantly higher expression primary tumors CC cell lines SiHa ME180. Upon cisplatin treatment cells display significant overexpression its hyperactivation. olaparib shows...
The Forkhead transcription factor FOXO1, an important downstream target of phosphatidylinositol-3-kinase (PI3K)/AKT signaling pathway, regulates cellular homeostasis by maintaining cell proliferation, apoptosis and viability in normal cells.Though, the function regulation FOXO1 is well documented many cancers, molecular mechanism its cervical cancer largely unknown.In present study we have investigated role PI3K inhibition on regulation.Expression profiling primary tumors lines show over...
The cancer registry provides reliable data from the population. In this article, we provide burden and its patterns Varanasi district.
In the network of chemokine signaling pathways, recent reports have described SDF-1α/CXCR4 axis and its role in cancer progression metastasis. Interestingly, we found downregulation CXCR4 at both transcript protein level cervical cell lines primary tumors. We also promoter hypermethylation biopsy samples. DNA hypomethylating drug 5-AZA-2'-deoxycytidine histone deacetylase inhibitor Trichostatin A treatments reactivate transcription expression. Cell adhesion assay demonstrated that autocrine...
Abstract Background Lip and oral cavity cancer is leading cause of mortality among Indian men. This study evaluated diagnostic accuracy mobile health (mHealth) enabled screening for early detection premalignant lesions or (OPML/OC). It also described epidemiology tobacco other substance use associated in rural northern India. Methods A prospective enrolled 10,101 high‐risk individuals from settings Varanasi district, India, between February 2021 June 2023. Trained field workers captured...
Breast cancer emerged as number one among women worldwide in terms of incidence and mortality. Majority breast cancers diagnosed India are aged 45 years above. A low proportion Indian female population reproductive age group (30–49 years) underwent screening. The national operational framework includes mammography the investigation modalities under algorithm for early detection management cancer. This study describes prevalence associated factors uptake We utilized data from 35,083 ≥...
Platinum-refractory advanced head and neck squamous cell carcinoma (HNSCC) has poor outcomes limited treatment options, especially in resource-constrained settings. Triple oral metronomic chemotherapy (OMCT), involving low-dose continuous administration of chemotherapeutic agents, shown promise phase II studies but lacks evidence from randomized controlled trials. This study evaluated whether triple OMCT improves overall survival (OS) compared with physician discretion (CPD). In this III...
4007 Background: Locally advanced Gallbladder cancers (LAGBC)initially deemed not suitable for R0 resection receive either neoadjuvant chemotherapy (NACT)or chemoradiation (NACRT)downstaging and to improve outcomes. Methods: This is a randomized phase 3 trial (NCT02867865) that included fit patients with LAGBC adenocarcinoma,. T3/T4 liver infiltration ( > 2cm, < 5cm); N1 nodal status; obstructive jaundice (type I/II biliary obstruction) ;duodenal or colonic abutment no mucosal ,...
Doppler ultrasonography (US) is increasingly being utilized as an imaging modality in breast cancer. It used to study the vascular characteristics of tumor. Neoadjuvant chemotherapy standard treatment locally advanced Histological examination remains gold assess response. However, based on color findings, a new scoring system that could predict histological response following proposed.Fifty cases infiltrating duct carcinoma were studied. The mean age patients was 44.5 years. All underwent...