A5076384951- Multiple Myeloma Research and Treatments
- Chronic Lymphocytic Leukemia Research
- Tuberculosis Research and Epidemiology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Neutropenia and Cancer Infections
- Head and Neck Cancer Studies
- Gastric Cancer Management and Outcomes
- Lymphoma Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Lung Cancer Treatments and Mutations
- Frailty in Older Adults
- Protein Degradation and Inhibitors
- Cancer Genomics and Diagnostics
- Salivary Gland Tumors Diagnosis and Treatment
- Health Systems, Economic Evaluations, Quality of Life
- Radiomics and Machine Learning in Medical Imaging
- Peptidase Inhibition and Analysis
- Agricultural Practices and Plant Genetics
- Blood disorders and treatments
- Computational Drug Discovery Methods
- Cancer Treatment and Pharmacology
- Gallbladder and Bile Duct Disorders
- Agricultural pest management studies
- Chronic Myeloid Leukemia Treatments
- Greenhouse Technology and Climate Control
Bhabha Hospital
2024-2025
Tata Memorial Hospital
2006-2025
Homi Bhabha National Institute
2020-2025
Advanced Centre for Treatment, Research and Education in Cancer
2022-2024
Sri Sathya Sai Institute of Higher Medical Sciences
2024
Creative Commons
2023
New Delhi Tuberculosis Center
2017
Importance The role of olanzapine has not been adequately evaluated in moderately emetogenic chemotherapy (MEC) regimens with or without neurokinin-1 receptor antagonists. Objective To evaluate whether addition to an MEC regimen reduces nausea, vomiting, and use nausea rescue medications among patients solid malignant tumors. Design, Setting, Participants This multicenter, open-label phase 3 randomized clinical trial included aged 18 years older tumors who were receiving oxaliplatin-,...
LBA248 Background: The choice of optimal chemotherapy in advanced (unresectable/metastatic) gastroesophageal junction and gastric (GEJ/G) adenocarcinomas remains undecided with regard to the addition docetaxel a FOLFOX/CAPOX backbone improving outcomes equipoise duration as well. Methods: DOC GC study is multicentric open-label, randomized controlled phase III trial, adults ≥18 years GEJ/G adenocarcinoma adequate end-organ function. Patients were 1:1 one two arms: Arm A - modified CAPOX (3...
Abstract A larger percentage of our population is aging healthily and living on to a ripe old age. 60 years age taken as cut-off for identifying geriatric the purpose specialized healthcare. The incidence cancer increasing its expected more so in population. At present , there are limited centres where clinic being conducted. Some key unmet needs — lack resources time dedicated screening, validated interventions awareness about field oncology. proposed solutions orientation exposure trainees...
Platinum-refractory advanced head and neck squamous cell carcinoma (HNSCC) has poor outcomes limited treatment options, especially in resource-constrained settings. Triple oral metronomic chemotherapy (OMCT), involving low-dose continuous administration of chemotherapeutic agents, shown promise phase II studies but lacks evidence from randomized controlled trials. This study evaluated whether triple OMCT improves overall survival (OS) compared with physician discretion (CPD). In this III...
The plasma concentration of 5-Fluorouracil (5-FU) is affected by numerous factors, thereby limiting its efficacy. current therapeutic regimen's doses based on body surface area (BSA) are linked to increased toxicity and sometimes inadequate drug exposure.
Background: Efficacy and toxicity of TKIs may vary depending on the ethnic background or genetic factors; hence it is important to gather data from individual populations pertaining each drug. The pivotal registration trial had not enrolled any patient India there are very limited published studies its efficacy as well safety Indian patients with CML. Methods: Hospital Electronic Medical Record was screened for adult (age > 18 years) CML registered (n = 1290) at our hospital 1st May 2018...
We evaluated whether the addition of docetaxel (D) to a combination comprising 5-fluorouracil/leucovorin (5-FU/LV) or capecitabine (C) plus oxaliplatin (O) (DOF/DOX) improved overall survival (OS) compared with 6 months 5-fluorouracil (5-FU) in (FOLFOX/CAPOX) alone advanced HER2-negative gastroesophageal junction and gastric adenocarcinomas (G/GEJ).
Seven district-level Nutritional Rehabilitation Centres (NRCs) in Bihar, India provide clinical and nutritional care for children with severe acute malnutrition (SAM).To assess whether intensified case finding (ICF) strategies at NRCs can lead to pediatric detection among SAM link them TB treatment under the Revised National Tuberculosis Control Programme (RNTCP).A retrospective cohort study was conducted that included medical record reviews of registered screening RNTCP during July-December...
The KRAS p.G12C mutation occurs in seen 13% of non-small cell lung cancers (NSCLCs) and approximately 1%–3% colorectal other cancers. Until the last decade, there were no approved therapies for targeting mutation, but recently, drugs have been discovered. is a small protein structurally without any deep pockets making it almost impossible to target. Furthermore, binds its active state with GTP protein, remarkably close affinity blockage challenging. Sotorasib nanomolecule that selectively...
CASE SUMMARY History and examination A 77-year-old gentleman, with no prior comorbidities or a family history of malignancy, presented in October 2021 to the outpatient department Tata Memorial Hospital, Mumbai, India, complaints loss appetite unintentional weight (of approximately 12 kgs) over past 5 months. In May 2021, he experienced an episode acute urinary retention, which required catheterization. He was prescribed tablet tamsulosin for this. view persistent repeated lower tract...
PURPOSE Patients with chemotherapy-responsive advanced biliary tract cancers (BTCs) are usually observed after 6 months of gemcitabine-based therapy. There is limited prospective evidence for maintenance strategies chemotherapy. METHODS This investigator-initiated, open-label, randomized, integrated phase II-III study enrolled adult patients BTC from two cancer centers in India. histologically confirmed adenocarcinoma who had at least disease stabilization chemotherapy were randomly assigned...
Metastatic breast cancer (MBC) patients have numerous options for treatment. However, it is essential to consider treatments with favorable toxicity profiles and convenient modes of administration. Eribulin has shown effectiveness in aggressive MBC, but there a lack sufficient real-world data specific Indian patients. We conducted retrospective audit MBC who received intravenous between 2019 2023 at dosage 1.4 mg/m2 on days 1 8 every 3 weeks. The median Progression-free survival (PFS)...
The data regarding the use of neoadjuvant chemotherapy in technically unresectable head and neck cancer (HNC) is limited real-world studies are needed to look for efficacy toxicities this approach.This a retrospective study conducted Medical Oncology department our hospital. All HNC patients who underwent between May 2018 2020 were included analysis. Patients received three-drug regimen docetaxel, cisplatin 5-fluorouracil (DCF) regimen, two-drug regimens docetaxel + cisplatin, paclitaxel...
ABSTRACT Export Background: Bloodstream infections are the major cause of life-threatening complications in febrile neutropenic patients with hematolymphoid malignancies. The prevalence these bloodstream is 20-30%. bacteria that most frequently isolated belong to Enterobacterales and Pseudomonas species. overall infection attributable mortality rate 21.5%. Objective: main objective this study was evaluate multidrug-resistant (MDR) organisms adult malignancies neutropenia at our newly...
Lakhan KasyapIntroduction Gallbladder cancer (GBC) is the 20th most common in India with a crude incidence rate of 2.3 per 100,000 persons. Of note, it relatively states which fall Gangetic plains. Patients often present advanced stage and have an unfavorable prognosis. Materials Methods From January to June 2021, 170 treatment-naive GBC (adenocarcinoma) patients who were registered at tertiary care center North India, included. Data extracted from electronic medical records was analyzed...
<title>Abstract</title> Background Diverse strategies, including addressing various social barriers, especially among key vulnerable populations, are needed to accelerate efforts achieve India’s goal of ending TB by 2025. In this direction, a baseline study was conducted covering migrant, tribal, tea garden, urban and mining/industrial populations in four Indian states: Assam, Bihar, Telangana, Karnataka. This aimed generate evidence about tuberculosis-related knowledge, levels stigma,...
Salivary gland tumours are rare cancers with variable course and prognosis. There is a paucity of data, especially for the advanced stages.This retrospective analysis carried out in our institute. All patients seeking treatment incurable salivary from October 2018 to September 2022 were included. Relevant clinical data collected appropriate statistical was applied.30 included analysis. The parotid most common site origin (73%). Adenoid cystic carcinoma (ACC) duct (SDC) equally (37%)...
ABSTRACT Background: Breast lymphomas are a rare group of malignancies that further subdivided into primary and secondary. AIMS: To study the pathological clinical course breast lymphomas. Materials Methods: This is retrospective analysis patients treated at our institute over period 4.5 years from September 2018 to February 2023. The details all diagnosed with lymphoma were reviewed analysed for histomorphological, immunohistochemical, clinical, treatment details. Appropriate statistical...
LBA6053 Background: Advanced HNSCC has poor outcomes and limited treatment options, especially in resource-constrained settings. Immunotherapy is affordable for less than 5% of patients lower-middle-income countries (LMICs). Triple OMCT, employing low-dose continuous chemotherapy, shows promise, but its safety efficacy along with chemotherapy remain unproven. We aimed to assess whether the addition OMCT first-line can improve overall survival (OS) as compared alone. Methods: This phase 3...