A5048785031- Orthopedic Infections and Treatments
- Total Knee Arthroplasty Outcomes
- Orthopaedic implants and arthroplasty
- Hip disorders and treatments
- Orthopedic Surgery and Rehabilitation
- Musculoskeletal Disorders and Rehabilitation
- Shoulder Injury and Treatment
- RNA Interference and Gene Delivery
- Elbow and Forearm Trauma Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Knee injuries and reconstruction techniques
- Bone fractures and treatments
- Surgical site infection prevention
- Mesenchymal stem cell research
- Osteoarthritis Treatment and Mechanisms
- Virus-based gene therapy research
- Hip and Femur Fractures
- Veterinary Orthopedics and Neurology
- Bacterial Identification and Susceptibility Testing
- Antimicrobial Resistance in Staphylococcus
- Pelvic and Acetabular Injuries
- Vibrio bacteria research studies
- Esophageal and GI Pathology
- Neuroscience and Neuropharmacology Research
- Cardiac electrophysiology and arrhythmias
University of Maryland, Baltimore
2020-2025
University of Maryland Medical Center
2021-2025
Royal Preston Hospital
2024
Mayo Clinic
2024
Rothman Institute
2024
Thomas Jefferson University
2024
Rothman Orthopaedics
2024
University of Toledo
2016-2020
Florida College
2019
University of Florida
2019
The multilineage differentiation potential of adult tissue-derived mesenchymal progenitor cells (MPCs), such as those from bone marrow and trabecular bone, makes them a useful model to investigate mechanisms regulating tissue development regeneration, cartilage. Treatment with transforming growth factor-beta (TGF-beta) superfamily members is key requirement for the in vitro chondrogenic MPCs. Intracellular signaling cascades, particularly involving mitogen-activated protein (MAP) kinases,...
The in vitro culture of human trabecular bone-derived cells has served as a useful system for the investigation biology osteoblasts. recent discovery our laboratory multilineage mesenchymal differentiation potential derived from collagenase-treated bone fragments prompted further interest view application progenitor (MPCs) repair and regeneration tissue damaged by disease or trauma. Similar to MPCs marrow, clearer understanding variability associated with obtaining these is required order...
BackgroundIn response to the COVID-19 pandemic, hospitals in United States were recommended stop performing elective procedures. This stoppage has led cancellation of a large number hip and knee arthroplasties. The effect this on patients' physical mental economic health is unknown.MethodsA survey was developed by AAHKS Research Committee assess pain, anxiety, function, ability patients undergo delayed operation. Six institutions conducted 360 who had have arthroplasty cancelled between...
The American Academy of Orthopaedic Surgeons, together with Hip Society, Association and Knee College Radiology, Physical Therapy Association, recently released the updated 2023 Management Osteoarthritis Evidence-Based Clinical Practice Guidelines. 8 recommendations 9 options comprise these guidelines intended to optimize treatment outcomes in a patient population that is growing exponentially over time. In this article, we present case studies illustrate utilization clinical practice...
Patellar instability following total knee arthroplasty (TKA) is a rare, yet serious complication, potentially requiring revision surgery or resulting in chronic dysfunction. When encountered, it paramount to understand the etiologies, diagnostic approaches, treatment options, and outcomes of selected treatment. The most common cause patella improper positioning components, leading lateral maltracking patella. Factors such as internal rotation and/or medialization femoral tibial components...
Germ cell apoptosis, which occurs normally during spermatogenesis, increases after testosterone withdrawal from the testis. The molecular mechanism by this remains uncertain. Fas system has been implicated as a possible key regulator of apoptosis in various cells: binding ligand (FasL), type II transmembrane protein, to Fas, I receptor triggers cells expressing Fas. Recently, localized germ cells, and FasL Sertoli within rat We hypothesized that protein content would rise response reduced...
Abstract Periprosthetic joint infections are a devastating complication of replacement surgery. One novel therapeutic that has potential to change the current treatment paradigm is bacteriophage therapy. Herein, we discuss our experiences with therapy for 10 recalcitrant periprosthetic and review protocols utilized achieve successful outcomes.
Frequenin, a Ca 2+ -binding protein, has previously been implicated in the regulation of neurotransmission, possibly by affecting ion channel function. Here, we provide direct evidence that frequenin is potent and specific modulator Kv4 channels, principal molecular components subthreshold activating A-type K + currents. Frequenin increases Kv4.2 current amplitudes (partly enhancing surface expression proteins) it slows inactivation time course -dependent manner. It also accelerates recovery...
A desirable strategy for articular cartilage repair is to surgically replace the damaged area with an in vitro-engineered osteochondral plug. We report here development of a novel construct using human trabecular bone-derived mesenchymal progenitor cells and biodegradable poly-D,L-lactic acid scaffold. The layer was fabricated by press-coating chondrifying high-density cell pellet onto scaffold, which then loaded previously initiated undergo osteogenesis. composite cultured cocktail medium...
Elbow motion is essential for upper extremity function to position the hand in space. Unfortunately, elbow joint prone stiffness following a multitude of traumatic and atraumatic etiologies. can be diagnosed with complete history physical exam, supplemented appropriate imaging studies. The stiff challenging treat, thus, its prevention paramount importance. When this approach fails, non-operative followed by operative treatment modalities should pursued. Upon initial presentation those who...
Conditionally replicative adenoviruses (CRAds) represent a novel treatment strategy for malignant glioma. Recent studies suggest that the cytopathic effect elicited by these vectors is mediated through autophagy, form of programmed cell death. Likewise, temozolomide (TMZ), chemotherapeutic agent used gliomas, also triggers autophagic In this study, we examined potential to combine two treatments in setting experimental vitro, pretreatment with TMZ followed CRAd-Surivin-pk7 enhanced...
The Management of Osteoarthritis (OA) the Hip Evidence-Based Clinical Practice Guideline is based on a systematic review published studies examining treatment OA hip in adults (aged 18 years and older). Based best current available evidence, this guideline contains eight recommendations nine options to assist orthopaedic surgeons all qualified physicians managing patients who have been diagnosed by trained healthcare provider with are currently undergoing treatment. It also intended serve as...
Bacteriophage therapy is a potential adjunctive treatment for periprosthetic joint infections (PJIs) given the capabilities of bacteriophages to degrade biofilms, self-replicate, and lyse bacteria. However, many aspects this therapeutic are ill-defined, narrow spectrum bacteriophage activity along with limited available strains curb use specific bacteria such as Staphylococcus aureus at present time. Therefore, aim study was determine feasibility using PJI by (1) categorizing causative...