A5001282919- Antifungal resistance and susceptibility
- Liver Disease and Transplantation
- Tuberculosis Research and Epidemiology
- Liver Disease Diagnosis and Treatment
- Mycobacterium research and diagnosis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Infectious Diseases and Tuberculosis
- Fungal Infections and Studies
- Pneumonia and Respiratory Infections
- Cancer-related molecular mechanisms research
- Drug-Induced Hepatotoxicity and Protection
- AI in cancer detection
- Lung Cancer Diagnosis and Treatment
- Diagnosis and treatment of tuberculosis
- Immune Response and Inflammation
- Systemic Lupus Erythematosus Research
- Cytomegalovirus and herpesvirus research
- Apelin-related biomedical research
- Acute Kidney Injury Research
- Sirtuins and Resveratrol in Medicine
- Oral Health Pathology and Treatment
- Inflammasome and immune disorders
- Pancreatitis Pathology and Treatment
- Organ Transplantation Techniques and Outcomes
- Infectious Diseases and Mycology
Taipei Veterans General Hospital
2012-2024
National Yang Ming Chiao Tung University
2015-2023
National Yang Ming University Hospital
2015
National Taiwan University
2000
Institute of Biomedical Sciences, Academia Sinica
1998
Sputum smears and culture conversion are frequently used to evaluate treatment response in pulmonary tuberculosis patients. Limited data available on the evaluation of correlation between under-treatment sputum smear results conversion. This prospective study included culture-proven patients at six hospitals Taiwan. At least two sets were collected completion 8 weeks TB treatment. The sensitivities specificities 2-month estimated based status. A total 371 enrolled for analysis. Factors...
Abstract Background Pyrazinamide (PZA) is an important first-line drug in multidrug-resistant tuberculosis (MDRTB) treatment. However, the unreliable results obtained from traditional susceptibility testing limits its usefulness clinical settings. The detection of pncA gene mutations a potential surrogate PZA testing, especially MDRTB isolates. impact genotypes M. also remains to be clarified. Methods isolates were collected six hospitals Taiwan January 2007 December 2009. sequencing,...
The MRL-lpr/lpr and MRL-(++) mice were studied for the expression of cytokines in spleen, lymph node, thymus, kidney brain through reverse transcription-polymerase chain reaction (RT-PCR). frequencies IL-4 TNF-alpha thymus spleen significantly higher than from age 17 to 32 weeks. More importantly, transcript was demonstrated early rather terminal stage lupus disease. At 20th week, with active disease exhibited concentrations IL-1 alpha, IL-6 serum mice. Interestingly, but not mice,...
Neuraminidase inhibitors (NAIs) including oseltamivir and peramivir are used for influenza treatment. A systemic corticosteroid is usually administrated acute respiratory distress syndrome. The aim of this study was to investigate the effect a its interaction with NAIs in patients infection distress.A retrospective survey hospitalized infected from January 2012 May 2014 conducted medical center Taiwan.Eighty-six were during period. Forty-eight had 39 them (81.3%, 39/48) supported by...
Immunosuppression induced by Mycobacterium tuberculosis is important in the pathogenesis of active (TB). However, impact depressed TB-specific and non-TB-specific gamma interferon (IFN-γ) response on treatment outcomes TB patients remains uncertain.
In non-alcoholic steatohepatitis (NASH), muscle wasting was an aggravating factor for the progression of hepatic steatosis. This study explores potential benefits chronic treatment with resveratrol, a strong activator SIRT1 on NASH mice. vivo and in vitro study, we evaluate SIRT1-dependent mechanisms effects resveratrol administration 6 weeks high-fat-methionine choline deficient diet-induced mice palmitate-pretreated C2C12 myoblast cells. Resveratrol improved grip strength mass limbs,...
(1) Background: The presentation of chronic pulmonary aspergillosis (CPA) ranges from single granuloma to fibrosis in the affected lung. CPA can be divided into five categories according European Respirology Society (ERS) guidance but is usually assessed by clinical physicians. Computer-based quantitative lung parenchyma analysis and its correlation with manifestations, systemic inflammation, angiogenesis have never been investigated. (2) Method: Forty-nine patients 36 controls were...
Scimitar syndrome is a rare congenital heart disease. It divided into subgroups of infantile, adult, and multiple cardiac extracardiac malformation. Most patients are diagnosed during infancy occasionally in adolescence, but very few older than 20 years age, only some cases have severe symptoms that require surgical correction. We report case man 54 age who was with asymptomatic scimitar insignificant left-to-right shunt (Qp/Qs = 1.51) medical history type 2 diabetes mellitus hyperlipidemia....
Cytomegalovirus (CMV) causes life-threatening infections in immunocompromised host. The clinical significance of asymptomatic CMV viruria patients receiving hematopoietic stem cell transplantation (HSCT) remains unclear. This study aims to clarify whether antiviral therapy is associated with a favorable outcome. HSCT recipients whose urine was culture-positive for were retrospectively reviewed and followed. Viruria episodes divided according or not used. Mortality the estimated glomerular...
Background: Cirrhotic complications resulting from portal hypertension can be considerably reduced by non-selective beta-blockers (NSBBs); however, scarce studies have investigated therapeutic agents for other complications. We aimed to investigate the effects of NSBBs on common cirrhotic infection, acute kidney injury (AKI), chronic renal function declination, and sarcopenic changes. Methods: Medical records hospitalization cirrhosis with at least a 4-year follow-up were analyzed selected...
Aims Treatment of non‐alcoholic steatohepatitis (NASH) is difficult due to the absence a proven treatment and its comprehensive mechanisms. In NASH animal model, upregulated hepatic inflammation oxidative stress, with resultant M1 polarization macrophages as well imbalanced adipocytokines, all accelerate progression. As member tumor necrosis factor receptor superfamily, decoy 3 (DcR3) not only neutralizes death ligands, but also performs immune modulations. this study, we aimed investigate...
Abstract Background The diagnostic cut‐off value for chronic pulmonary Aspergillosis (CPA) by Aspergillus fumigatus ‐specific IgG has never been evaluated In Taiwan. flavus not worldwide. Objectives Evaluate of and its application characteristics. Patients/Methods Blood from control groups treatment‐naïve patients with CPA infections was collected measurements. Controls were who had chest radiographic abnormalities signs respiratory tract infection, but negative resolved without anti‐mould...
Endotoxemia-activated tumor necrosis factor (TNFα)/nuclear kappa B (NFκB) signals result in acute on chronic inflammation-driven renal dysfunction advanced cirrhosis. Systemic activation of peroxisome proliferator-activated receptor gamma (PPARγ) with pioglitazone can suppress inflammation-related splanchnic and pulmonary This study explored the mechanism effects treatment abovementioned cirrhotic rats. Cirrhotic ascitic rats were induced by bile duct ligation (BDL). Then, 2 weeks (Pio, PPAR...
Aims Increases in the systemic vasodilator adrenomedullin and renal vasoconstrictors thromboxane A 2 cirrhotic patients are pathogenic factors for development of functional acute kidney injury (AKI), including pre‐renal azotemia (PRA) hepatorenal syndrome (HRS), which is associated with high mortality. This study aims to find biomarkers that can diagnose HRS at an early stage, enable treatment as soon possible. Methods Acute decompensated who had been admitted hospital were enrolled this...
Genetic variants and dysfunctional monocyte had been reported to be associated with infection susceptibility in advanced cirrhotic patients. This study aims explore genetic predictive markers relevant immune dysfunction that contributed severe sepsis febrile acute de-compensated patents. Polymorphism analysis of candidate genes was undergone 108 patients 121 healthy volunteers. Various plasma inflammatory/regulatory cytokines, proportion classical (CD 16-, phagocytic) non-classical (CD16+,...
Background Suppression of cardiac iinflammasome, which can be inhibited by Farnesoid X receptor (FXR) agonist, ameliorate inflammation and fibrosis. Increased inflammasome decrease the abundance regulatory T (Treg) cells exacerbate dysfunction. Interaction between cardiomyocytes Treg is involved in development nonalcoholic steatohepatitis (NASH)-related Aims This study evaluates whether FXR agonist obeticholic acid (OCA) treatment improves NASH-associated Methods The vivo vitro mechanisms...
Cirrhosis-related hepatic and renal endothelial dysfunction is characterized by macrophage-endothelium adhesion-mediated inflammation, glycocalyx/barrier damage, impaired vasodilation. Activation of adenosine A2A receptor (A2AR) protects cirrhotic rats from impairment microcirculation post hepatectomy. This study evaluates the effects A2AR activation on cirrhosis-related in biliary receiving two weeks agonist PSB0777 [bile duct ligated (BDL)+PSB0777] treatment. Endothelial liver, vessels,...
Alcoholic cirrhosis (AC) leads to enormous disease burden and occupies a substantial proportion in the etiology of hepatocellular carcinoma (HCC), but scarce attention has been paid this topic. Besides, propranolol reported decrease rate HCC viral hepatitis. We conducted retrospective tertiary-center cohort study identify incidence AC patients with or without propranolol. A total 1,046 hospitalization had screened, those regular follow-up for three years otherwise until date malignancy...