A5043687522- Immunotherapy and Immune Responses
- Extracellular vesicles in disease
- Recommender Systems and Techniques
- Immune cells in cancer
- Advanced Bandit Algorithms Research
- Atherosclerosis and Cardiovascular Diseases
- Nutrition and Health in Aging
- Adipokines, Inflammation, and Metabolic Diseases
- Metabolism, Diabetes, and Cancer
- Monoclonal and Polyclonal Antibodies Research
- Muscle Physiology and Disorders
- Expert finding and Q&A systems
- Peptidase Inhibition and Analysis
- RNA Interference and Gene Delivery
- Systemic Lupus Erythematosus Research
- GDF15 and Related Biomarkers
- CAR-T cell therapy research
- Adipose Tissue and Metabolism
- interferon and immune responses
Daegu Gyeongbuk Institute of Science and Technology
2019-2023
T cell-derived small extracellular vesicles (sEVs) exhibit anti-cancer effects. However, their potential should be reinforced to enhance clinical applicability. Herein, we generated interleukin-2-tethered sEVs (IL2-sEVs) from engineered Jurkat cells expressing IL2 at the plasma membrane via a flexible linker induce an autocrine effect. IL2-sEVs increased ability of CD8+ without affecting regulatory (Treg ) and down-regulated cellular exosomal PD-L1 expression in melanoma cells, causing...
Patients with cancer undergoing chemotherapy experience cachexia anorexia, body weight loss, and the depletion of skeletal muscles adipose tissues. Effective treatment strategies for chemotherapy-induced are scarce. The growth differentiation factor 15 (GDF15)/GDNF family receptor alpha-like (GFRAL)/rearranged during transfection (RET) axis is a critical signalling pathway in cachexia. In this study, we developed fully human GFRAL antagonist antibody investigated whether it inhibits...
Modern recommendation systems are mostly based on implicit feedback data which can be quite noisy due to false positives (FPs) caused by many reasons, such as misclicks or quick curiosity. Numerous algorithms collaborative filtering have leveraged post-click user behavior (e.g., skip) identify positives. They effectively involved these in the model supervision negative-like signals. Yet, had not been considered existing session-based (SBRs) although they provide just deleterious effects. To...
Abstract Membrane‐tethering technology for proteins (MTFP) is a promising approach the development of therapeutic agents that display bioactive proteins, such as antibodies and cytokines, on cell surface, resulting in induction autocrine signalling. In this review article, we provide comprehensive overview MTFP, including its basic principles, selection agonist peptides, identification novel functions natural cytokines. Furthermore, discuss potential increasing efficacy existing treatments...