A5042633687- BRCA gene mutations in cancer
- Advanced Breast Cancer Therapies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Musculoskeletal pain and rehabilitation
- PARP inhibition in cancer therapy
- Health Systems, Economic Evaluations, Quality of Life
- Multiple and Secondary Primary Cancers
- Multiple Sclerosis Research Studies
- Lymphoma Diagnosis and Treatment
- Economic and Financial Impacts of Cancer
- Cancer Genomics and Diagnostics
- Respiratory and Cough-Related Research
- COVID-19 and healthcare impacts
- Long-Term Effects of COVID-19
- Spine and Intervertebral Disc Pathology
- Chronic Lymphocytic Leukemia Research
- Intensive Care Unit Cognitive Disorders
- Dermatology and Skin Diseases
- Chronic Disease Management Strategies
- Ergonomics and Musculoskeletal Disorders
- Brain Metastases and Treatment
- Global Cancer Incidence and Screening
- Delphi Technique in Research
- Osteoarthritis Treatment and Mechanisms
- Cancer survivorship and care
Adelphi Group (United Kingdom)
2019-2025
Hindustan Aeronautics Limited (India)
2021
Massey University
2021
Burton Hospitals NHS Foundation Trust
2021
Long COVID, a diverse set of symptoms that persist after minimum 4 weeks from the initial SARS-CoV-2 infection, has posed substantial burden to healthcare systems. There is some evidence COVID-19 vaccination may be associated with lower risk long COVID. However, little known about association between status and COVID-associated resource utilisation (HCRU) costs. We conducted cohort study using primary care electronic health record data in England Clinical Practice Research Datalink (CPRD)...
Objective The aim of the study is to estimate COVID-19 absenteeism and indirect costs, by care setting. Methods A population-based retrospective cohort using data from German Statutory Health Insurance (SHI) database define outpatient (April 2020–December 2021) hospitalized 2020–October 2022) cohorts employed working-aged individuals. Results In ( N = 369,220), median duration associated cost was 10.0 (Q1, Q3: 5.0, 15.0) days €1061 (530, 1591), respectively. n 20,687), 15.0 (7.0, 32.0) €1591...
Genetic mutations in breast cancer susceptibility gene 1 or 2 (BRCA1/2) confer a high risk for developing cancer; however, at least 50% of women with BRCA1/2 go undiagnosed. This study evaluated differences patient demographics, clinical characteristics, and mutation testing the USA, European Union (EU4), Israel real-world population patients human epidermal growth factor receptor 2-negative (HER2-) advanced (ABC). was retrospective analysis data from Adelphi Real World ABC Disease Specific...
Symptom burden of patients with moderate-to-severe atopic dermatitisBackground: Atopic dermatitis (AD) is a chronic inflammatory skin disease associated intense and persistent pruritus.Objectives: To examine associations between AD symptoms health-related quality life (HRQoL) in adults (aged ≥18 years) AD. Materials & Methods: Patient chart survey data from physicians within Europe were derived the Adelphi Disease Specific Programme (Q3 2019-Q2 2020).HRQoL measures included Euro-Qol...
Objective Osteoarthritis (OA) affects 10% of adults in the UK. Despite over one-third people with OA experiencing chronic pain, few studies have examined population-level impact pain associated OA. We compared resource-use and epidemiological outcomes patients mild, moderate severe OA-associated matched controls without known Design Retrospective, longitudinal, observational cohort study (July 2008 to June 2019). Setting Electronic records extracted from Clinical Practice Research Datalink...
Guidelines recommend starting bone-targeted agents (BTA), such as zoledronic acid and denosumab, soon bone metastases (BMs) are definitively diagnosed in all patients with breast cancer (BC) or castration-resistant prostate (CRPC) whether they symptomatic not. Data were analyzed from 1364 BC 1161 CRPC who had BMs receiving anti-cancer therapy hospitals across six European countries (Belgium, France, Germany, Italy, Spain the UK). The 731 physicians (medical oncologists urologists) provided...
Objective: To quantify the burden of work-relevant persistent musculoskeletal (MSK) pain to a large UK employer. Methods: A retrospective, longitudinal, analytical cohort study using linked Rolls-Royce data systems. Cases were employees with MSK-related referral occupational health; controls age-, sex-, and job role-matched without such referral. Outcomes compared during 12 months’ follow-up. Results: Overall, 2382 matched case–control pairs identified (mean age: 46 y; 82% male). took 39,200...
Poly(adenosine diphosphate-ribose) polymerase inhibitors are approved to treat patients harboring a germline breast cancer susceptibility gene 1 or 2 mutation (BRCA1/2mut) with human epidermal growth factor receptor 2—negative (HER2−) advanced (ABC). This study evaluated differences in patient demographics, clinical characteristics, and BRCA1/2mut testing within the United States (US), European Union 4 (EU4; France, Germany, Italy, Spain), Israel real-world population of HER2− ABC....
Aim: To investigate the association of discordance in patient- and physician-reported symptoms on health-related quality life (HRQoL) hepatocellular carcinoma (HCC). Patients & methods: Data were drawn from a point-in-time survey physicians patients conducted Germany, Italy Spain (October 2018 – January 2019). Physicians their consulting independently reported baseline characteristics, symptoms, treatment history satisfaction, HRQoL derived using Functional Assessment Cancer...
<b>Introduction:</b> Patient characteristics of new users single-device inhalers for COPD are unknown. We describe and treatments patients with newly initiating dual or triple single-inhaler therapies in routine care the UK. <b>Methods:</b> This is a retrospective cohort study using linked UK primary secondary data diagnosis, aged ≥35 years, evidence smoking history therapy (long-acting muscarinic antagonist [LAMA]/long-acting β2-agonist [LABA] inhaled corticosteroid [ICS]/LABA) fluticasone...
ABSTRACT Background Long COVID, a diverse set of symptoms that persist after minimum 4 weeks from the initial SARS-CoV-2 infection, has posed substantial burden to healthcare systems. There is some evidence COVID-19 vaccination may be associated with lower risk long COVID. However, little known about association between status and COVID-associated resource utilisation (HCRU) costs. Methods We conducted cohort study using primary care electronic health record data in England Clinical Practice...
To describe and compare demographics outcomes among patients with schizophrenia who have switched atypical treatments versus non-switchers.Data were extracted from the Adelphi Schizophrenia Disease Specific Programme™ conducted January to May 2014 in United States. Participating physicians provided information on their next 10 consulting aged ≥ 18 years; same invited voluntarily complete a patient self-completion form (PSC). Patients considered switchers (S) or non-switchers (NS) based...
Abstract Background In clinical trials, poly (ADP-ribose) polymerase inhibitors (PARPi) versus chemotherapy resulted in significantly improved progression-free survival, manageable adverse event profiles, and favorable patient-reported outcomes (PROs) patients with human epidermal growth factor receptor 2–negative (HER2−) advanced breast cancer (ABC) germline BRCA1/2 mutations (g mut). The objective of this study was to evaluate PROs physician satisfaction treatment g mut HER2− ABC receiving...
<b>Introduction:</b> COPD patients are considered at risk of severe COVID-19 illness, however there limited data on the burden disease in this patient population. This study investigated rate diagnosis and hospitalization for due to (pre-vaccination) over time, stratified by severity. <b>Methods:</b> A retrospective cohort aged ≥35 years, FEV<sub>1</sub>/FVC score <0.7, indexed from Mar–Aug 2020, using English Clinical Practice Research Datalink Aurum database Hospital Episode Statistics...
"HSR21-062: Real-World Study of BRCA1/2 Mutation (BRCA1/2mut) Testing Among Adult Patients (pts) With HER2− Advanced Breast Cancer (ABC) in the US" published on 17 Mar 2021 by National Comprehensive Network.
10598 Background: African Americans (AA) have the highest breast cancer (BC) mortality rate. Access to treatment is a known contributing factor. In past 4 years, several targeted therapies for HER2- BC become available which require testing specific biomarkers. This study assessed impact of race on biomarker rates in ABC pts receiving US. Methods: Oncologists were recruited abstract data from medical charts next 8-10 with during Sept 2019-Apr 2020. Pts records stratified by and categorized...
Introduction: Until recently, oral advanced therapies (AT) for moderate to severe ulcerative colitis (UC) were not available in the EU5 (France, Germany, Spain, Italy, United Kingdom), with patients receiving only subcutaneous injection or intravenous infusion AT until 2018. The unmet need treatment and ease of administration among gastroenterologists (GEs) UC based on a 2017 survey was assessed. Methods: Data drawn from Adelphi Real World Disease Specific Programme (DSP™) Inflammatory Bowel...