A5044375662- COVID-19 and healthcare impacts
- Respiratory Support and Mechanisms
- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Neurotoxicity Research
- Anesthesia and Sedative Agents
- Infection Control and Ventilation
- Airway Management and Intubation Techniques
- Mitochondrial Function and Pathology
- Thermal Regulation in Medicine
- Metabolism and Genetic Disorders
- Intensive Care Unit Cognitive Disorders
- Pituitary Gland Disorders and Treatments
- Congenital Anomalies and Fetal Surgery
- Ion Transport and Channel Regulation
- Sepsis Diagnosis and Treatment
- Abdominal Surgery and Complications
- Intraoperative Neuromonitoring and Anesthetic Effects
- Enhanced Recovery After Surgery
- Tracheal and airway disorders
- Congenital Heart Disease Studies
- Diet and metabolism studies
- Mechanical Circulatory Support Devices
- Anesthesia and Pain Management
- Cardiac Valve Diseases and Treatments
- Coronary Artery Anomalies
The University of Texas Southwestern Medical Center
2018-2024
Cleveland Clinic
2024
Outcomes Research Consortium
2020-2023
Medical City Children's Hospital
2023
University of Florida
2020-2021
Southwestern Medical Center
2020
Concern over potential neurotoxicity of anesthetics has led to growing interest in prospective clinical trials using potentially less toxic anesthetic regimens, especially for prolonged anesthesia infants. Preclinical studies suggest that dexmedetomidine may have a reduced neurotoxic profile compared other conventional regimens; however, coadministration with either drugs (eg, remifentanil) and/or regional blockade is required achieve adequate surgery. The feasibility this pharmacological...
Coronavirus disease 2019 (COVID-19) is associated with high perioperative morbidity and mortality among adults. The incidence severity of anesthetic complications in children severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) unknown. We hypothesized that there would be an increased intra- postoperative SARS-CoV-2 infection as compared to those negative testing. conducted a retrospective cohort study analyzing for <18 years age who underwent anesthesia between April 28 September...
Abstract Introduction Fluid administration is an important aspect of the management children undergoing liver transplantation and may impact postoperative outcomes. Our aim was to evaluate association between volume intraoperative fluid our primary outcome, duration mechanical ventilation following pediatric transplantation. Secondary outcomes included intensive care unit length stay hospital stay. Methods We conducted a multicenter, retrospective cohort study using electronic data from...
Background: The TREX (Trial Remifentanil DEXmedetomidine) trial aimed to determine if, in children < 2 years old, low-dose sevoflurane/dexmedetomidine/remifentanil anesthesia (LD-SEVO) is superior standard dose sevoflurane (STD-SEVO) terms of global cognitive function at 3 age. aim the present secondary analyses was compare incidence intraoperative hypotension and bradycardia, postoperative pain, time recovery, need for treatment light treatment, pain medications, morbidity mortality...
Abstract Background Anesthetic regimens using dexmedetomidine and short‐acting opioids have been suggested as potential alternatives to sevoflurane‐based anesthesia in children. The primary aim of this study is compare demographics, intraoperative characteristics, complications general anesthetics which were used without sevoflurane, or combination with a low sevoflurane concentration, children 36 months old younger. secondary evaluate bispectral index (BIS) values when available these...
The authors reports no conflicts of interest. IRB approval was obtained for the parent study, which this is a subgroup analysis. This abstract presented at World Airway Management Meeting in November 2019 Amsterdam. It also published Trends Anaesthesia and Critical Care February 2020:https://doi.org/10.1016/j.tacc.2019.12.118.
Propionic acidemia is a rare genetic disorder of metabolism that predisposes patients to metabolic acidosis, lethargy, neurologic dysfunction, developmental delays, and cardiomyopathy. Perioperative anesthetic management guided toward mitigating the effects preoperative fasting times, maintaining normovolemia, preventing cardiovascular complications secondary underlying Commonly used agents may have undesirable side in these patients. Propofol, lactate Lactated Ringer's, neuromuscular...
Nociception is the detection of noxious stimulation by nervous system. The PMD-200 monitor a validated, emerging technology for intraoperative monitoring using nociception level (NOL) index. We describe pediatric case an open resection paraganglionic masses during which episodic increases in NOL index and blood pressure coincided with tumor manipulation, presumably due to catecholamine surge. Since patient was under stable adequate analgesia, likely reflected physiologic effects handling...
Children with mitochondrial disorders represent a subset of patients who require unique anesthetic considerations. Routinely administered medications for general anesthesia, such as propofol, have been shown to increase the risk developing metabolic acidosis. In addition, both depolarizing and nondepolarizing neuromuscular blockers are contraindicated due hyperkalemic cardiac arrest worsening preexisting muscle weakness, respectively. These limitations pose challenges while choosing...
A four-month-old female infant presented for a thoracoscopic aortopexy severe tracheomalacia. The case proceeded uneventfully until specimen bag was introduced into the chest to remove thymus. child developed significant ST segment elevations in all 12 leads on electrocardiogram. An emergent intraoperative echocardiogram performed but did not reveal any findings account diffuse elevations. remained elevated 48 hours following procedure with no apparent hemodynamic instability or structural...