Background: Type 2 diabetes mellitus (T2DM) and its associated complications are of public health concern. Metformin is the most common pharmacological T2DM treatment, distributed through organic cation transporters (OCTs). The solute transporter family 22A1 (SLC22A1) gene encodes OCT1, variants may play a role in glycemic control. This study analyzed seven SLC22A1 their potential association with control patients from Northern Mexico undergoing metformin monotherapy. Methods:...

Abstract. Spatial predictions of total organic carbon (TOC) concentrations and stocks are crucial for understanding marine sediments’ role as a significant sink in the global cycle. In this study, we present geospatial prediction TOC at 5 x arc minute grid scale, using deep learning model — novel machine approach based on new compilation over 22,000 measurements set predictors, such seafloor lithologies, grain size distribution, an alpha-chlorophyll satellite data. our compared discuss...

ABSTRACT The mother‐of‐pearl oyster Pinctada mazatlanica (Hanley, 1856) obtained full protection from the Mexican government after fishery collapse in 1939. P. was listed 1994 as a threatened species “Special Protection” category. However, no quantitative assessment of state population has been done so far. Our study is most comprehensive summer interannual monitoring program conducted far Eastern Pacific using SCUBA diving censuses 314 sampling sites located along between 1998 and 2021. We...

Abstract. Spatial predictions of total organic carbon (TOC) concentrations and stocks are crucial for understanding marine sediments’ role as a significant sink in the global cycle. In this study, we present geospatial prediction TOC on 5 × arcmin grid, using novel neural network approach. We also provide apply new compilation over 21 000 measurements set predictors, including features such seafloor lithologies, benthic oxygen fluxes, chlorophyll-a satellite data. Moreover, compare different...

The subcellular distribution of Dp71 isoforms alternatively spliced for exon 71 and/or 78 was examined. cDNA sequence each variant fused to the C‐terminus green fluorescent protein and constructs were transfected transiently in cell lines HeLa, C2C12 N1E‐115. proteins determined by confocal microscope analysis. isoform lacking amino acids encoded exons found exclusively cytoplasm whereas variants containing show a predominant nuclear localization. localization provides new clue towards...

The objective of this study was to identify and characterize yeast strains isolated from the ruminal ecosystem that are capable enhancing fermentation in bovines consume high-fibre diets recommended by livestock feed guidelines Cuba. yeasts were rumen Holsteincows had been fed a biofermented product. Isolated colonies purified, identified, characterized using biochemical molecular methods, their effects on compared measuring vitro gas production. Thirteen new production with potential use as...

Peroxisome proliferator-activated receptors (PPARs) play roles in glucose and lipid metabolism regulation. Pro12Ala PPAR-γ2 +294T/C PPAR-δ have been associated with dyslipidemia, hyperglycemia high body mass index (BMI). We compared metabolic traits determined associations or polymorphism among teenagers from different ethnicity. Four hundred twelve samples previous biochemical biometric measurements were used. Genomic DNA peripheral blood was extracted analyzed by end-point PCR for PPAR-γ2....

Obesity is thought to be associated with a reduced capacity increase fat oxidation in response physical exercise; however, scientific evidence supporting this paradigm remains scarce. This study aimed determine the interrelationship of different submaximal exercise metabolic flexibility (Metflex) markers and define its association body fatness on subjects obesity. Twenty-one male obesity performed graded-intensity protocol (Test 1) during which cardiorespiratory fitness (CRF), maximal (MFO)...

Purpose: This work studies the interrelation of first ventilatory threshold (VT1), heart rate inflection point (HRIP), and exercise intensity at which blood lactate started to accumulate (LIAB) or increased 1 mmol∙L-1 above baseline (LT+1.0); examinee their association with eliciting maximal fat oxidation (FATmax). Methods: Eighteen young men obesity performed an incremental-load test on a treadmill after overnight fasting. Gas exchange, rate, concentration were recorded. Linear regression...

Glucose and lipid metabolism regulation by the peroxisome proliferator-activated receptors (PPARs) has been extensively reported. However, role of their polymorphisms remains unclear. Objective: To determine relation between PPAR-γ2 rs1801282 (Pro12Ala) PPAR-β/δ rs2016520 (+294T/C) metabolic biomarkers in adults with type 2 diabetes (T2D). Materials Methods: We included 314 patients T2D. Information on anthropometric, fasting plasma glucose (FPG), HbA1c profile measurements was taken from...

The type IA of the isolated deficiencies (ID) growth (HGH) and placental lactogen (HPL) hormones are frequently consequence deletions in their respective genes. To facilitate diagnosis these cases, we developed a rapid method for detecting genes involved based on polymerase chain reaction (PCR) technique. This consist simultaneous amplification via consensus primers 5 which conform hGH-hPL multigene family, followed by identification each them product gene-specific patterns restriction...

Background Obesity and diabetes mellitus prevalence has increased during the past decade among adults adolescents in Mexico. According to la Encuesta Nacional de Salud y Nutricion 2006, 30% of adult population is obese 39% overweight, whereas close 31%. Diabetes estimated be 14.4% Mexican [1]. Metabolic syndrome (MS) defined as a cluster risk factors including abdominal obesity, dyslipidemia, glucose intolerance hypertension, presence three or more components increases for heart disease,...

Este estudio realizado en adolescentes de las etnias Menonita, Tarahumara y Mestiza del estado Chihuahua, pretende hacer una descripción los componentes riesgo para síndrome metabólico (SM) que la vida actual tiene nuestra población, predisponen a un gran número enfermedades metabólicas. Se revisaron variables: edad, sexo, IMC, circunferencia cintura, glucosa ayunas, colesterol total, triglicéridos, c-HDL presión arterial. Las variables fueron comparadas acuerdo con diversos criterios...

Obtener ovocitos madurados in vitro, que sean competentes para fertilizarse y originar un porcentaje superior al 50 % de blastocitos viables, es una las principales metas existen en el desarrollo vitro embriones bovinos. Es por ello necesario entender los procesos celulares, desembocan la maduración del ovocito durante foliculogénesis su subsecuente transición embrión. La embrión proceso complejo involucra inactivación genómica activación genoma embrionario. Este se da bovinos etapa 8 a 16...

During germline establishment and its molecular control, the Figla gene, which codes a transcription factor, is preferentially expressed in oocytes, key for oogenesis/folliculogenesis, ovarian function, female fertility. However, specific subcellular localization (cytoplasmic or nuclear) of this factor unknown. We analyzed FIGLA protein using computer programs NucPred, SubCellProt, NLStradamus to predict localization; also, we established platform artificial expression murine gene cultured...