A5073877462- Radiopharmaceutical Chemistry and Applications
- Cancer, Hypoxia, and Metabolism
- Amino Acid Enzymes and Metabolism
- Click Chemistry and Applications
- Medical Imaging Techniques and Applications
- Thyroid Cancer Diagnosis and Treatment
- Peroxisome Proliferator-Activated Receptors
- S100 Proteins and Annexins
- Lanthanide and Transition Metal Complexes
- RNA Research and Splicing
- Lung Cancer Treatments and Mutations
- Microbial bioremediation and biosurfactants
- Advanced biosensing and bioanalysis techniques
- Peptidase Inhibition and Analysis
- Chemotherapy-induced cardiotoxicity and mitigation
- Genetic and Kidney Cyst Diseases
- SARS-CoV-2 detection and testing
- PI3K/AKT/mTOR signaling in cancer
- Biotin and Related Studies
- Anaerobic Digestion and Biogas Production
- Environmental Chemistry and Analysis
- Congenital heart defects research
- Fibroblast Growth Factor Research
- Advanced Nanomaterials in Catalysis
- Nuclear Structure and Function
University of Birmingham
2022-2024
Aalborg University Hospital
2022
Beaumont Hospital
2022
Newham University Hospital
2022
Alagappa University
2021
University of Sheffield
2019-2021
University of Groningen
2012-2019
Dialyse Centrum Groningen
2013
Peroxisomes are ubiquitous eukaryotic organelles, which perform a plethora of functions including hydrogen peroxide metabolism and β-oxidation fatty acids. Reactive oxygen species produced by peroxisomes major contributing factor to cellular oxidative stress, is supposed significantly accelerate ageing cell death according the free radical theory ageing. However, relative mitochondria, role other peroxisomes, in these degenerative pathways has not been extensively investigated. In this...
We demonstrate that the peroxin Pex3 is not required for formation of peroxisomal membrane structures in yeast pex3 mutant cells. Notably, cells already contain reticular and vesicular harbor key proteins receptor docking complex—Pex13 Pex14—as well as matrix Pex8 alcohol oxidase. Other these are unstable transiently localized to cytosol (Pex10, Pmp47) or endoplasmic reticulum (Pex11). These more abundant a atg1 double deletion strain, absence may render them susceptible autophagic...
In recent years, the development of a nano-conjugate system for drug delivery applications has gained attention among researchers. Keeping this in mind, study, we developed doxorubicin-platinum conjugate that targeted breast cancer cell lines. To achieve this, platinum nanoparticles using polyvinylpyrrolidone (PVP). High resolution-transmission electron microscopy (HR-TEM) revealed occurrence octopod-shaped nanoparticles. Subsequently, doxorubicin (DOX) was conjugated on surface as-prepared...
We demonstrated that in the yeast Hansenula polymorpha peroxisome fission and degradation are coupled processes important to remove intra-organellar protein aggregates. Protein aggregates were formed peroxisomes upon synthesis of a mutant catalase variant. showed introduction these peroxisomal lumen had physiological disadvantages as it affected growth caused enhanced levels reactive oxygen species. Formation was followed by asymmetric separate aggregate from mother organelle. Subsequently,...
The primary cilium is a cellular sensor that detects light, chemicals, and movement important for morphogen growth factor signaling. small GTPase Rab11–Rab8 cascade required ciliogenesis. Rab11 traffics the guanine nucleotide exchange (GEF) Rabin8 to centrosome activate Rab8, needed ciliary growth. also requires transport particle protein complex (TRAPPC) proteins recruitment during Here, using an MS-based approach identifying Rabin8-interacting proteins, we identified C7orf43 (also known as...
Herein, we report facile theranostic platinum nanoparticles (PtNPs) conjugated to an anticancer drug, doxorubicin (DOX), in unraveling the inhibition of a cell survival PI3K/AKT (phosphatidylinositol 3-kinase/protein kinase B) signaling pathway MCF-7 and MDA-MB-231 human breast cancer cells. The significant features our DOX@PtNPs as platform are follows: (i) drug release studies showed progressive pH-dependent delivery; (ii) vitro displayed relatively higher cytotoxicity cells compared...
Here, we describe a novel peroxin, Pex37, in the yeast Hansenula polymorpha . H. Pex37 is peroxisomal membrane protein, which belongs to protein family that includes, among others, Neurospora crassa Woronin body Wsc, human PXMP 2, Saccharomyces cerevisiae mitochondrial inner Sym1, and its mammalian homologue MPV 17. We show deletion of PEX 37 does not appear have significant effect on peroxisome biogenesis or proliferation cells grown at peroxisome‐inducing growth conditions (methanol)....
Abstract Purpose: Patients with aggressive thyroid cancer are frequently failed by the central therapy of ablative radioiodide (RAI) uptake, due to reduced plasma membrane (PM) localization sodium/iodide symporter (NIS). We aimed understand how NIS is endocytosed away from PM human cells, and whether this was druggable in vivo. Experimental Design: Informed analysis endocytic gene expression patients cancer, we used mutagenesis, NanoBiT interaction assays, cell surface biotinylation RAI...
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