A5014985292- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Lymphatic System and Diseases
- Biomarkers in Disease Mechanisms
- T-cell and B-cell Immunology
- Cell Adhesion Molecules Research
- IL-33, ST2, and ILC Pathways
- Cancer Cells and Metastasis
- Glycosylation and Glycoproteins Research
- CAR-T cell therapy research
- Effects of Vibration on Health
- Monoclonal and Polyclonal Antibodies Research
- TGF-β signaling in diseases
- Diabetes and associated disorders
University of Birmingham
2015-2017
Queen Elizabeth Hospital Birmingham
2015-2017
Abstract Lymphangiogenesis associated with tertiary lymphoid structure (TLS) has been reported in numerous studies. However, the kinetics and dynamic changes occurring to lymphatic vascular network during TLS development have not studied. Using a viral-induced, resolving model of formation salivary glands adult mice we demonstrate that expansion is tightly regulated. Lymphatic vessel occurs two distinct phases. The first wave dependent on IL-7. second phase, responsible for leukocyte exit...
<h3>Background and objectives</h3> Follicular dendritic cells (FDCs) are a stromal cell population located within the germinal centre responsible for antigen presentation process of B affinity maturation. Although FDC function is well established, origin differentiation these still debated. A recent publication (Jarjour <i>et al</i>. JEM 2014) used multicolour fate mapping techniques to show that lymph node in inflamed nodes derive from marginal reticular (MRC), found underneath subcapsular...